INT79096

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Context Info
Confidence 0.48
First Reported 1999
Last Reported 2010
Negated 2
Speculated 1
Reported most in Abstract
Documents 12
Total Number 12
Disease Relevance 4.41
Pain Relevance 3.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Cyp2e1) oxidoreductase activity (Cyp2e1) endoplasmic reticulum (Cyp2e1)
enzyme binding (Cyp2e1)
Cyp2e1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 9 100.00 Very High Very High Very High
adenocard 4 100.00 Very High Very High Very High
Paracetamol 194 99.76 Very High Very High Very High
Bioavailability 2 99.00 Very High Very High Very High
monoamine 2 93.72 High High
alcohol 9 85.64 High High
carbamazepine 2 84.52 Quite High
cINOD 4 58.64 Quite High
fibrosis 7 49.76 Quite Low
Dopamine 1 22.72 Low Low
Disease Link Frequency Relevance Heat
Pancreatitis 14 100.00 Very High Very High Very High
Hepatotoxicity 25 98.60 Very High Very High Very High
Diabetes Mellitus 2 96.80 Very High Very High Very High
Stress 2 96.12 Very High Very High Very High
Death 46 94.44 High High
Disease Susceptibility 1 91.76 High High
Toxicity 25 91.56 High High
Liver Failure 2 90.52 High High
Alcoholic Pancreatitis 7 89.96 High High
Apoptosis 18 89.48 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We studied the effects of acarbose on the hepatotoxicity of carbon tetrachloride (CCl4) and acetaminophen (AP) in rats, both of which exert their toxic effects through bioactivation associated with cytochrome P450 2E1 (CYP2E1).
cytochrome P450 2E1 Binding (associated) of associated with paracetamol and hepatotoxicity
1) Confidence 0.48 Published 1999 Journal Hepatology Section Abstract Doc Link 9862862 Disease Relevance 0.26 Pain Relevance 0.34
We studied the effects of acarbose on the hepatotoxicity of carbon tetrachloride (CCl4) and acetaminophen (AP) in rats, both of which exert their toxic effects through bioactivation associated with cytochrome P450 2E1 (CYP2E1).
CYP2E1 Binding (associated) of associated with paracetamol and hepatotoxicity
2) Confidence 0.48 Published 1999 Journal Hepatology Section Abstract Doc Link 9862862 Disease Relevance 0.26 Pain Relevance 0.35
We studied the effects of TRZ on the hepatotoxicity of carbon tetrachloride (CCl(4)) and acetaminophen (APAP) in rats, both of which exert their toxic effects through bioactivation associated with cytochrome P450 3A (CYP3A) and 2E1 (CYP2E1).
CYP2E1 Binding (associated) of associated with paracetamol and hepatotoxicity
3) Confidence 0.35 Published 2002 Journal Toxicology Section Abstract Doc Link 12062933 Disease Relevance 0.60 Pain Relevance 0.41
Using phenacetin and chlorzoxazone as probe drugs, the activities of CYP1A2 and CYP2E1 were monitored in vivo.
CYP2E1 Binding (activities) of
4) Confidence 0.34 Published 2010 Journal J Asian Nat Prod Res Section Abstract Doc Link 20496194 Disease Relevance 0.08 Pain Relevance 0.07
Acetaminophen metabolism by CYP2E1 produces a chemically reactive metabolite, NAPQI, that might bind to sulfhydryl groups in cellular proteins, including mitochondrial proteins, inducing oxidative stress and leading to cellular damage and death [40], [41].
CYP2E1 Spec (might) Binding (bind) of associated with stress, paracetamol and death
5) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3000821 Disease Relevance 0.47 Pain Relevance 0.82
The objective of this work was to evaluate the possible in vitro interactions of S-adenosyl-l-methionine (SAM) and its metabolites S-(5'-Adenosyl)-l-homocysteine (SAH), 5'-Deoxy-5'-(methylthio)adenosine (MTA) and methionine with cytochrome P450 enzymes, in particular CYP2E1.
CYP2E1 Binding (interactions) of associated with adenocard
6) Confidence 0.32 Published 2005 Journal Biochem. Pharmacol. Section Abstract Doc Link 15763544 Disease Relevance 0 Pain Relevance 0.15
There were no significant differences in the distribution of genotypes of ALDH 2 and CYP2E1 among those three groups.
CYP2E1 Neg (no) Binding (genotypes) of
7) Confidence 0.21 Published 1999 Journal Alcohol. Clin. Exp. Res. Section Abstract Doc Link 10235286 Disease Relevance 1.14 Pain Relevance 0.37
Although probably best recognized as an inhibitor of drug metabolism, isoniazid has a biphasic effect of inhibition-induction on one cytochrome P450 isozyme, CYP2E1, which partially explains the interaction with acetaminophen and increased risk of hepatotoxicity.
CYP2E1 Binding (interaction) of associated with paracetamol and hepatotoxicity
8) Confidence 0.20 Published 1999 Journal Am. J. Med. Sci. Section Abstract Doc Link 10334118 Disease Relevance 0.18 Pain Relevance 0.23
Although probably best recognized as an inhibitor of drug metabolism, isoniazid has a biphasic effect of inhibition-induction on one cytochrome P450 isozyme, CYP2E1, which partially explains the interaction with acetaminophen and increased risk of hepatotoxicity.
CYP2E1 Binding (recognized) of associated with paracetamol and hepatotoxicity
9) Confidence 0.16 Published 1999 Journal Am. J. Med. Sci. Section Abstract Doc Link 10334118 Disease Relevance 0.18 Pain Relevance 0.24
There is evidence for females having lower activity of CYP1A2, CYP2E1, and UGT; higher activity of CYP3A4, CYP2A6, and CYP2B6; and no differences in CPY2C9 and CYP2D6 activity.
CYP2E1 Neg (no) Binding (activity) of
10) Confidence 0.08 Published 2008 Journal Int. Rev. Neurobiol. Section Abstract Doc Link 18929073 Disease Relevance 0.42 Pain Relevance 0.06
No specific microsatellite markers were detected in association with previously reported susceptibility genes for chronic pancreatitis, such as PRSS1, PRSS2, CTRC, SPINK1, CFTR, ALDH2, and CYP2E1.
CYP2E1 Binding (association) of associated with chronic pancreatitis
11) Confidence 0.05 Published 2008 Journal Dis. Markers Section Abstract Doc Link 19096130 Disease Relevance 0.57 Pain Relevance 0.44
However, it was not clear from this study whether anti-apoptogenic and anti-necrotic effects of GSPE were: (i) due to its interference with endonuclease activity, (ii) due to its antioxidant effect, or, (iii) due to its ability to inhibit microsomal drug metabolizing enzyme(s), such as CYP-4502E1.
CYP-4502E1 Binding (inhibit) of
12) Confidence 0.04 Published 2001 Journal Mol. Cell. Biochem. Section Abstract Doc Link 11330834 Disease Relevance 0.25 Pain Relevance 0.32

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