INT79099

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Context Info
Confidence 0.20
First Reported 1998
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.06
Pain Relevance 1.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Gtpbp4) nucleolus (Gtpbp4) nucleus (Gtpbp4)
GTPase activity (Gtpbp4) ribosome biogenesis (Gtpbp4) cytoplasm (Gtpbp4)
Gtpbp4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
substantia gelatinosa 6 95.36 Very High Very High Very High
agonist 8 93.08 High High
parabrachial 4 88.92 High High
Opioid 6 85.40 High High
opioid receptor 1 75.92 Quite High
Enkephalin 2 75.08 Quite High
Substantia gelatinosa neuron 2 75.00 Quite High
mu opioid receptor 1 60.64 Quite High
Endogenous opioid 1 56.88 Quite High
MU agonist 1 56.80 Quite High
Disease Link Frequency Relevance Heat
Pre-term Labor 4 56.56 Quite High
INFLAMMATION 2 41.88 Quite Low
Dysmenorrhea 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The degree of decrease in G-protein activation by terbutaline was in harmony with its cervical resistance-increasing action.
Negative_regulation (decrease) of Positive_regulation (activation) of G-protein
1) Confidence 0.20 Published 2005 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 15645294 Disease Relevance 0.06 Pain Relevance 0.05
The [(35)S]GTPgammaS binding assay demonstrated a decreased G-protein activation on the days of pregnancy investigated, but no activation was found in the nonpregnant samples.
Negative_regulation (decreased) of Positive_regulation (activation) of G-protein
2) Confidence 0.20 Published 2005 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 15645294 Disease Relevance 0 Pain Relevance 0.03
Further, intracellular application of guanosine-5'-O-(2-thiodiphosphate) (GDP-beta-S; 500 microM), which blocks G-protein activation, abolished the effects of DAMGO.
Negative_regulation (blocks) of Positive_regulation (activation) of G-protein
3) Confidence 0.19 Published 1998 Journal J. Neurophysiol. Section Abstract Doc Link 9862898 Disease Relevance 0 Pain Relevance 0.80
Nlxz infusion prevented DAMGO stimulation of G-protein coupling in LPBNi and markedly reduced this stimulation in the MPBN.
Negative_regulation (prevented) of Positive_regulation (stimulation) of G-protein
4) Confidence 0.04 Published 2008 Journal Brain Res. Section Abstract Doc Link 18805404 Disease Relevance 0 Pain Relevance 0.43

General Comments

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