INT791

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Context Info
Confidence 0.44
First Reported 1978
Last Reported 2001
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.27
Pain Relevance 1.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitosis (Mastl) cytoskeleton (Mastl) nucleus (Mastl)
cell cycle (Mastl) cell division (Mastl) kinase activity (Mastl)
Anatomy Link Frequency
brain 2
Mastl (Mus musculus)
Pain Link Frequency Relevance Heat
Antinociceptive 2 99.72 Very High Very High Very High
Dopamine 1 98.76 Very High Very High Very High
Morphine 9 97.98 Very High Very High Very High
narcan 3 94.40 High High
Catecholamine 3 93.92 High High
antinociception 1 92.24 High High
tolerance 2 88.60 High High
tail-flick 1 79.84 Quite High
Cannabinoid 4 75.00 Quite High
cocaine 4 59.84 Quite High
Disease Link Frequency Relevance Heat
Hypothermia 2 92.76 High High
Sprains And Strains 1 85.68 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Morphine produced greater increases in dopamine synthesis and was a more potent antinociceptive agent, while THC produced greater increases in norepinephrine synthesis and was a more potent hypothermic agent.
Positive_regulation (increases) of Gene_expression (produced) of THC associated with dopamine, antinociceptive and morphine
1) Confidence 0.44 Published 1978 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 97703 Disease Relevance 0.27 Pain Relevance 1.23
We have shown previously that CBD pretreatment of mice increases brain levels of THC and have now further characterized this effect and determined whether the brain pharmacokinetics of other drugs are also affected.
Positive_regulation (increases) of Gene_expression (levels) of THC in brain
2) Confidence 0.08 Published 2001 Journal Biochem. Pharmacol. Section Abstract Doc Link 11331071 Disease Relevance 0 Pain Relevance 0.13

General Comments

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