INT79113

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Context Info
Confidence 0.12
First Reported 1998
Last Reported 2004
Negated 2
Speculated 0
Reported most in Abstract
Documents 12
Total Number 12
Disease Relevance 3.15
Pain Relevance 5.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
neurons 2
spinal cord 2
brain 2
microglial cells 2
substantia gelatinosa 1
LOC682801 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
sodium channel 35 100.00 Very High Very High Very High
c fibre 3 99.84 Very High Very High Very High
Spinal cord 12 99.68 Very High Very High Very High
substantia gelatinosa 3 99.58 Very High Very High Very High
Dorsal horn 2 98.76 Very High Very High Very High
Neuropathic pain 14 98.36 Very High Very High Very High
tetrodotoxin 6 97.52 Very High Very High Very High
nav1.8 4 95.68 Very High Very High Very High
Lamotrigine 3 95.56 Very High Very High Very High
agonist 10 95.20 Very High Very High Very High
Disease Link Frequency Relevance Heat
Neuropathic Pain 22 99.08 Very High Very High Very High
Injury 12 95.32 Very High Very High Very High
Neuroblastoma 3 86.08 High High
Ganglion Cysts 6 79.80 Quite High
INFLAMMATION 4 77.92 Quite High
Cancer 4 74.56 Quite High
Necrosis 4 74.08 Quite High
Dysmenorrhea 1 55.64 Quite High
Apoptosis 2 35.52 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We characterize the expression of seven sodium channel alpha-subunit and the beta1- and beta2-subunit mRNAs.
Gene_expression (expression) of beta1 associated with sodium channel
1) Confidence 0.12 Published 2004 Journal Neuroreport Section Abstract Doc Link 15129178 Disease Relevance 0 Pain Relevance 0.81
After 1-day treatment with 17beta-estradiol, the decrease in the expression of alpha3 and beta1 without a change in Na+/K+-ATPase activity suggests that some isoform other than beta1 exist in rat uteri.
Gene_expression (expression) of beta1
2) Confidence 0.07 Published 2000 Journal Chin J Physiol Section Abstract Doc Link 10857462 Disease Relevance 0.06 Pain Relevance 0.06
Effects of norepinephrine on rat cultured microglial cells that express alpha1, alpha2, beta1 and beta2 adrenergic receptors.
Gene_expression (express) of beta1 in microglial cells
3) Confidence 0.06 Published 2002 Journal Neuropharmacology Section Title Doc Link 12423672 Disease Relevance 0.30 Pain Relevance 0.37
Reverse transcriptase polymerase chain reaction studies revealed that microglial cells expressed mRNAs encoding alpha1A, alpha2A, beta1 and beta2 receptors.
Gene_expression (expressed) of beta1 in microglial cells
4) Confidence 0.06 Published 2002 Journal Neuropharmacology Section Abstract Doc Link 12423672 Disease Relevance 0.37 Pain Relevance 0.44
Using in situ hybridization histochemistry we have shown that the expression of the beta1 and beta2 subunits within the dorsal horn of the spinal cord of neuropathic rats is differentially regulated by a chronic constrictive injury to the sciatic nerve.
Gene_expression (expression) of beta1 in spinal cord associated with injury, neuropathic pain, dorsal horn, sciatic nerve and spinal cord
5) Confidence 0.05 Published 1999 Journal Neuroscience Section Abstract Doc Link 10188942 Disease Relevance 0.56 Pain Relevance 0.55
The sodium channel auxiliary subunits beta1 and beta2 are differentially expressed in the spinal cord of neuropathic rats.
Gene_expression (expressed) of beta1 in spinal cord associated with neuropathic pain, sodium channel and spinal cord
6) Confidence 0.04 Published 1999 Journal Neuroscience Section Title Doc Link 10188942 Disease Relevance 0.54 Pain Relevance 0.59
These results confirm that the pyrethroid binding site is intrinsic to the sodium channel alpha subunit and demonstrate that coexpression of the rat brain IIa alpha subunit with the rat beta1 subunit alters the apparent affinity of this site for pyrethroids.
Gene_expression (coexpression) of beta1 in brain associated with sodium channel
7) Confidence 0.03 Published 1998 Journal Neurotoxicology Section Abstract Doc Link 9863771 Disease Relevance 0 Pain Relevance 0.21
Concentration-response curves obtained using normalized tail current amplitude as an index of the extent of sodium channel modification by cypermethrin revealed that coexpression of the rat brain IIa alpha subunit with the rat beta1 subunit increased the apparent affinity of the sodium channel binding site for cypermethrin by more than 20-fold.
Gene_expression (coexpression) of beta1 in brain associated with sodium channel
8) Confidence 0.02 Published 1998 Journal Neurotoxicology Section Abstract Doc Link 9863771 Disease Relevance 0 Pain Relevance 0.30
RT-PCR analysis of wild type ND7-23 cells revealed endogenous expression of the beta1 and beta3 accessory Na+ channel subunits-the possibility that the presence of these subunits assists and stabilises expression of rNaV1.8 is discussed.
Gene_expression (expression) of beta1
9) Confidence 0.02 Published 2004 Journal Neuropharmacology Section Abstract Doc Link 14975698 Disease Relevance 0.75 Pain Relevance 0.90
However, of the auxiliary subunits, beta1 is expressed preferentially in only large- and medium-diameter neurons of the DRG while beta2 is absent in all DRG cells.
Neg (absent) Gene_expression (expressed) of beta1 in neurons
10) Confidence 0.02 Published 2000 Journal Eur. J. Neurosci. Section Abstract Doc Link 11069594 Disease Relevance 0.15 Pain Relevance 0.37
In the spinal cord, beta3 transcript was present specifically in layers I/II (substantia gelatinosa) and layer X, while beta1 mRNA was expressed in all laminae throughout the grey matter.
Gene_expression (expressed) of beta1 in substantia gelatinosa associated with substantia gelatinosa and spinal cord
11) Confidence 0.01 Published 2000 Journal Eur. J. Neurosci. Section Abstract Doc Link 11069594 Disease Relevance 0.27 Pain Relevance 0.55
In situ hybridization studies demonstrated high levels of beta3 mRNA in small-diameter c-fibres, while beta1 mRNA was virtually absent in these cell types but was expressed in 100% of large-diameter neurons.
Neg (absent) Gene_expression (expressed) of beta1 in neurons associated with c fibre
12) Confidence 0.01 Published 2000 Journal Eur. J. Neurosci. Section Abstract Doc Link 11069594 Disease Relevance 0.15 Pain Relevance 0.47

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