INT79115

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Context Info
Confidence 0.47
First Reported 1998
Last Reported 2007
Negated 0
Speculated 1
Reported most in Body
Documents 12
Total Number 13
Disease Relevance 4.21
Pain Relevance 0.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Tap1) mitochondrion (Tap1) endoplasmic reticulum (Tap1)
ATPase activity (Tap1) plasma membrane (Tap1) transmembrane transport (Tap1)
Anatomy Link Frequency
spleens 2
tendon 1
Tap1 (Mus musculus)
Pain Link Frequency Relevance Heat
spinal inflammation 14 98.08 Very High Very High Very High
Pain 6 88.48 High High
cytokine 53 50.00 Quite Low
Potency 17 22.28 Low Low
rheumatoid arthritis 17 5.00 Very Low Very Low Very Low
Inflammation 17 5.00 Very Low Very Low Very Low
Central nervous system 7 5.00 Very Low Very Low Very Low
anesthesia 7 5.00 Very Low Very Low Very Low
adenocard 7 5.00 Very Low Very Low Very Low
isoflurane 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 21 99.74 Very High Very High Very High
Rupture 23 99.62 Very High Very High Very High
Flatfoot 14 99.52 Very High Very High Very High
Uveitis 9 99.40 Very High Very High Very High
Infection 330 99.32 Very High Very High Very High
Low Back Pain 14 98.08 Very High Very High Very High
Tendinitis And Tenosynovitis 20 96.20 Very High Very High Very High
Congenital Anomalies 5 93.08 High High
Cold Sores 214 91.20 High High
Leukemia 4 86.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To exclude the possibility that the effect seen with VV-hTAP1,2 was the result of VV-dependent alteration of proteasome function interacting with TAP over-expression, VV-NP-VSV was used in the coinfections as the source of antigen instead of VSV [14].
TAP Binding (interacting) of
1) Confidence 0.47 Published 2005 Journal PLoS Pathogens Section Body Doc Link PMC1323471 Disease Relevance 0.27 Pain Relevance 0
This would imply that when mouse TAP1 or TAP2 associates with its human TAP counterpart, they play a dominant role in selecting the peptides for transport.
TAP1 Binding (associates) of
2) Confidence 0.47 Published 2005 Journal PLoS Pathogens Section Body Doc Link PMC1323471 Disease Relevance 0 Pain Relevance 0
In addition, the SV-NP epitope has an aromatic residue (phenylalanine) at the peptide position 1 (N-terminus), and this has a strong deleterious effect for human TAP binding [24] and for transport.
TAP Binding (binding) of
3) Confidence 0.41 Published 2005 Journal PLoS Pathogens Section Body Doc Link PMC1323471 Disease Relevance 0 Pain Relevance 0
Calculations based on the threshold cycle number indicated that the abundance of human TAP1 mRNA was equal to mouse TAP1 mRNA 4 and 8 h after infection, but decreased to 2% of endogenous mouse TAP1 mRNA by 24 h after infection.
TAP1 mRNA Binding (equal) of associated with infection
4) Confidence 0.36 Published 2005 Journal PLoS Pathogens Section Body Doc Link PMC1323471 Disease Relevance 0.37 Pain Relevance 0
RT-PCR was used to detect human TAP1 and TAP2, and mouse TAP1 and TAP2, in spleens 24 h after infection.
TAP1 Binding (detect) of in spleens associated with infection
5) Confidence 0.36 Published 2005 Journal PLoS Pathogens Section Body Doc Link PMC1323471 Disease Relevance 0.25 Pain Relevance 0
RT-PCR was used to detect human TAP1 and TAP2, and mouse TAP1 and TAP2, in spleens 24 h after infection.
TAP1 Binding (detect) of in spleens associated with infection
6) Confidence 0.36 Published 2005 Journal PLoS Pathogens Section Body Doc Link PMC1323471 Disease Relevance 0.25 Pain Relevance 0
Immune evasion is additionally induced by the IE protein ICP47 which binds to transporter associated with antigen processing, TAP1/TAP2 and blocks the presentation of viral peptides by the major histocompatibility complex (MHC)-I [82].
TAP1 Binding (binds) of
7) Confidence 0.36 Published 2005 Journal Virol J Section Body Doc Link PMC1215526 Disease Relevance 0.40 Pain Relevance 0
This would imply that when mouse TAP1 or TAP2 associates with its human TAP counterpart, they play a dominant role in selecting the peptides for transport.
TAP Binding (counterpart) of
8) Confidence 0.32 Published 2005 Journal PLoS Pathogens Section Body Doc Link PMC1323471 Disease Relevance 0 Pain Relevance 0
Flexor Hallucis Longus tendon rupture in RA-patients is associated with MTP 1 damage and pes planus

Background

MTP 1 Binding (associated) of in tendon associated with rupture, flatfoot and rheumatoid arthritis
9) Confidence 0.20 Published 2007 Journal BMC Musculoskelet Disord Section Title Doc Link PMC2198913 Disease Relevance 1.24 Pain Relevance 0.09
We studied the influence of polymorphism in the transporter associated with antigen processing (TAP) genes, including point mutations not previously analyzed.
TAP Spec (analyzed) Binding (associated) of
10) Confidence 0.05 Published 2000 Journal Exp. Clin. Immunogenet. Section Abstract Doc Link 11096258 Disease Relevance 0.17 Pain Relevance 0.17
Formal confirmation of a linkage between the TAP and HLA-B loci would probably require family studies.


TAP Binding (linkage) of
11) Confidence 0.05 Published 2000 Journal Exp. Clin. Immunogenet. Section Body Doc Link 11096258 Disease Relevance 0 Pain Relevance 0
Transporter associated with antigen processing (TAP) 1 and TAP2 polymorphism influences the range of peptide presented by HLA class I molecules.
TAP Binding (associated) of
12) Confidence 0.05 Published 1998 Journal Tissue Antigens Section Abstract Doc Link 9864038 Disease Relevance 1.02 Pain Relevance 0.51
The wild-type B*2704 and N97D mutants were associated with TAP, CNX and CLR, although HC10 forms of mutant N97D interact more weakly with TAP.
TAP Binding (associated) of
13) Confidence 0.04 Published 2006 Journal Int. Immunol. Section Abstract Doc Link 16361312 Disease Relevance 0.24 Pain Relevance 0.18

General Comments

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