INT79136

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Context Info
Confidence 0.39
First Reported 1998
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.66
Pain Relevance 3.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Flvcr2) transmembrane transport (Flvcr2)
Anatomy Link Frequency
substantia nigra 1
kidney cortex 1
fibroblasts 1
thalamus 1
Flvcr2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate 9 100.00 Very High Very High Very High
sSRI 8 100.00 Very High Very High Very High
Dopamine 2 99.98 Very High Very High Very High
Serotonin 2 99.98 Very High Very High Very High
cocaine 12 99.78 Very High Very High Very High
Ventral tegmentum 1 99.68 Very High Very High Very High
addiction 6 98.68 Very High Very High Very High
monoamine 3 98.56 Very High Very High Very High
Morphine 10 98.24 Very High Very High Very High
Substantia nigra 1 98.12 Very High Very High Very High
Disease Link Frequency Relevance Heat
Morphine Dependence 6 98.68 Very High Very High Very High
Targeted Disruption 1 93.40 High High
Recurrence 1 91.44 High High
Affective Disorder 1 74.60 Quite High
INFLAMMATION 1 57.60 Quite High
Disease 1 5.00 Very Low Very Low Very Low
Mental Disorders 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
NaSi-1 transporter mRNA level in kidney cortex and protein level in BBM were significantly lower in animals pretreated with IBU compared with that in control animals.
Transcription (level) of transporter in kidney cortex
1) Confidence 0.39 Published 1998 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9864297 Disease Relevance 0.06 Pain Relevance 0.12
Monoamine transporter expression was differentially altered by cocaine; dopamine transporter mRNA levels in the ventral tegmental area, but not in the substantia nigra, were increased following withdrawal from cocaine, suggesting a role for the upregulated mesolimbic dopamine transporter in the mechanisms underlying relapse to cocaine taking.
Transcription (levels) of transporter in substantia nigra associated with ventral tegmentum, dopamine, substantia nigra, withdrawal, recurrence, cocaine and monoamine
2) Confidence 0.35 Published 2000 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 11072100 Disease Relevance 0.09 Pain Relevance 1.28
By Northern blot analysis, the expression of glial glutamate transporter GLT-1, but not GLAST, mRNA was decreased in the striatum/nucleus accumbens (NAc) and thalamus of morphine-dependent rats.
Transcription (expression) of transporter in thalamus associated with nucleus accumbens, glutamate, thalamus and morphine
3) Confidence 0.21 Published 2004 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 15542740 Disease Relevance 0.34 Pain Relevance 1.44
We found that mRNA of the serotonin transporter (SERT), a target of SSRIs, was expressed in rat-1 fibroblasts.
Transcription (expressed) of transporter in fibroblasts associated with ssri and serotonin
4) Confidence 0.13 Published 2008 Journal Life Sci. Section Abstract Doc Link 18482738 Disease Relevance 0.17 Pain Relevance 0.52

General Comments

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