INT79149

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Context Info
Confidence 0.58
First Reported 1998
Last Reported 2010
Negated 2
Speculated 2
Reported most in Body
Documents 26
Total Number 31
Disease Relevance 11.76
Pain Relevance 14.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
colon 4
spinal 2
neurons 1
spine 1
spinal cord 1
CSE (Homo sapiens)
Pain Link Frequency Relevance Heat
epidural 525 100.00 Very High Very High Very High
analgesia 389 100.00 Very High Very High Very High
Pain 146 99.96 Very High Very High Very High
Spinal cord 9 99.28 Very High Very High Very High
antiepileptic Drug 7 99.12 Very High Very High Very High
dorsal root ganglion 217 97.84 Very High Very High Very High
Regional anesthesia 1 95.64 Very High Very High Very High
intrathecal 93 94.56 High High
backache 3 94.16 High High
Opioid 83 94.08 High High
Disease Link Frequency Relevance Heat
Pain 150 99.96 Very High Very High Very High
Stress 16 99.84 Very High Very High Very High
Colitis 2 99.04 Very High Very High Very High
Pressure Volume 2 Under Development 11 98.90 Very High Very High Very High
Congenital Anomalies 10 97.92 Very High Very High Very High
Ganglion Cysts 217 97.84 Very High Very High Very High
Middle Cerebral Artery Infarction 76 97.80 Very High Very High Very High
Nociception 52 97.20 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 3 97.04 Very High Very High Very High
Injury 39 96.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The objective of this study was to predict which patients are at risk for CSEs, and compare the CSE profiles of all commonly used AEDs.
Gene_expression (profiles) of CSE associated with antiepileptic drug
1) Confidence 0.58 Published 2009 Journal Epilepsy Behav Section Abstract Doc Link 19010446 Disease Relevance 0.26 Pain Relevance 0.26
Comparison of CSE with conventional epidural technique for labor analgesia
Gene_expression (Comparison) of CSE associated with epidural and analgesia
2) Confidence 0.53 Published 2010 Journal International Journal of Women's Health Section Body Doc Link PMC2971703 Disease Relevance 0.56 Pain Relevance 1.29
Concerns of CSE for labor
Gene_expression (Concerns) of CSE associated with epidural
3) Confidence 0.53 Published 2010 Journal International Journal of Women's Health Section Body Doc Link PMC2971703 Disease Relevance 0.73 Pain Relevance 1.72
When compared with conventional epidural analgesia for labor, the incidence of overall failure, accidental intravascular placement of epidural catheter, inadequate epidural analgesia, and catheter replacements were shown to be significantly lower in patients receiving CSE analgesia.14 This difference may be due to the option to confirm questionable epidural needle location by successful spinal injection.15

Ambulatory labor analgesia

Gene_expression (receiving) of CSE in spinal associated with epidural and analgesia
4) Confidence 0.53 Published 2010 Journal International Journal of Women's Health Section Body Doc Link PMC2971703 Disease Relevance 0.08 Pain Relevance 1.44
To avoid some of these potential problems, special CSE sets have been produced.
Gene_expression (produced) of CSE associated with epidural
5) Confidence 0.52 Published 2001 Journal Reg Anesth Pain Med Section Abstract Doc Link 11172506 Disease Relevance 0 Pain Relevance 0.51
A total of 213 uncomplicated obstetric charts were reviewed in a 70-bed Air Force hospital that provided EPI, CSE, and ITA for obstetrical patients.
Gene_expression (provided) of CSE in EPI associated with epidural and analgesia
6) Confidence 0.43 Published 1998 Journal CRNA Section Abstract Doc Link 9866483 Disease Relevance 0.17 Pain Relevance 2.34
For 2 patients the NPB was favoured primarily, because they had undergone surgery of the lumbal spine, so that the CSE was not applicable.
Neg (not) Gene_expression (applicable) of CSE in spine
7) Confidence 0.32 Published 2010 Journal Aktuelle Urol Section Body Doc Link 19950054 Disease Relevance 0 Pain Relevance 0
IMPLICATIONS: Combined spinal epidural analgesia (CSE) produces pain relief during labor.
Gene_expression (produces) of CSE in spinal associated with pain, epidural and analgesia
8) Confidence 0.29 Published 2004 Journal Anesth. Analg. Section Abstract Doc Link 15041616 Disease Relevance 0.66 Pain Relevance 1.50
Exposure to NSAIDs reduced H(2)S formation and CSE expression (mRNA and protein) and activity by 60%-70%.
Gene_expression (expression) of CSE
9) Confidence 0.28 Published 2005 Journal Gastroenterology Section Body Doc Link 16230075 Disease Relevance 0.06 Pain Relevance 0
Exposure to NSAIDs inhibits Sp1 binding to its promoter and abrogates CSE expression in HEK-293 cells transfected with a vector containing the core CSE promoter.
Gene_expression (expression) of CSE
10) Confidence 0.28 Published 2005 Journal Gastroenterology Section Body Doc Link 16230075 Disease Relevance 0 Pain Relevance 0
The expression levels of rat OTR mRNA in the CSE (10(-7) pieces/ml) group were significantly higher than in the control group (P < 0.01).
Gene_expression (expression) of CSE
11) Confidence 0.26 Published 2006 Journal Reproduction Section Abstract Doc Link 16885542 Disease Relevance 0.32 Pain Relevance 0.07
Similarly, in preterm myometrial strips, the expression levels of human OTR mRNA in the CSE (10(-7) pieces/ml) group were significantly higher than in the control group (P < 0.05).
Gene_expression (expression) of CSE
12) Confidence 0.26 Published 2006 Journal Reproduction Section Abstract Doc Link 16885542 Disease Relevance 0.29 Pain Relevance 0.06
Hypotension, ephedrine use and period of motor recovery were more pronounced in CSE and CSE ((no-catheter)).
Gene_expression (pronounced) of CSE associated with pressure volume 2 under development and epidural
13) Confidence 0.22 Published 2004 Journal Anesth. Analg. Section Abstract Doc Link 14742393 Disease Relevance 0.26 Pain Relevance 1.01
Hypotension, ephedrine use and period of motor recovery were more pronounced in CSE and CSE ((no-catheter)).
Gene_expression (pronounced) of CSE associated with pressure volume 2 under development and epidural
14) Confidence 0.22 Published 2004 Journal Anesth. Analg. Section Abstract Doc Link 14742393 Disease Relevance 0.26 Pain Relevance 1.01
It is possible that CSE could aid in releasing of insulin from the surviving ?
Gene_expression (aid) of CSE
15) Confidence 0.20 Published 2009 Journal Nutr Metab (Lond) Section Body Doc Link PMC2785813 Disease Relevance 0.52 Pain Relevance 0
We found that CBS and CSE are expressed in the colon and spinal cord.
Gene_expression (expressed) of CSE in spinal cord associated with spinal cord
16) Confidence 0.16 Published 2006 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 16192316 Disease Relevance 0.66 Pain Relevance 0.37
Either the activity or protein expression of pancreatic CSE increased after the development of caerulein-induced pancreatitis in mice.
Gene_expression (expression) of CSE
17) Confidence 0.11 Published 2009 Journal Gut Section Body Doc Link 19201768 Disease Relevance 0.05 Pain Relevance 0
CONCLUSIONS: The data suggest that pancreatic NaHS/H(2)S most probably targets T-type Ca(2+) channels, leading to nociception, and that endogenous H(2)S produced by CSE and possibly T-type Ca(2+) channels are involved in pancreatitis-related pain.


Gene_expression (produced) of CSE
18) Confidence 0.11 Published 2009 Journal Gut Section Body Doc Link 19201768 Disease Relevance 0 Pain Relevance 0
Lactate dehydrogenase was measured to evaluate the role of antioxidative stress in the protection of CSE.
Gene_expression (protection) of CSE associated with stress
19) Confidence 0.07 Published 2010 Journal Behav Brain Funct Section Body Doc Link PMC2984477 Disease Relevance 1.04 Pain Relevance 0.05
H(2)S is synthesized from L-cysteine by either cystathionine beta-synthase (CBS) or cystathionine gamma-lyase (CSE), both using pyridoxal 5'-phosphate (vitamin B(6)) as a cofactor.
Gene_expression (synthesized) of CSE
20) Confidence 0.06 Published 2007 Journal Pharmacol Rep Section Abstract Doc Link 17377202 Disease Relevance 0 Pain Relevance 0.09

General Comments

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