INT79163

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Context Info
Confidence 0.29
First Reported 1998
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 5
Disease Relevance 3.18
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (PLG, CLEC3B) extracellular region (PLG, CLEC3B) peptidase activity (PLG)
plasma membrane (PLG) cytoplasm (CLEC3B)
Anatomy Link Frequency
hepatocyte 2
PLG (Homo sapiens)
CLEC3B (Homo sapiens)
Pain Link Frequency Relevance Heat
palliative 1 25.00 Low Low
tolerance 4 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Metastasis 96 96.16 Very High Very High Very High
Cancer 91 95.24 Very High Very High Very High
Malignant Neoplastic Disease 5 89.28 High High
Skin Cancer 188 88.44 High High
Solid Tumor 4 87.88 High High
Colon Cancer 8 84.48 Quite High
Advanced Or Metastatic Breast Cancer 5 81.20 Quite High
Ovarian Cancer 10 71.60 Quite High
Infection 1 70.64 Quite High
Alzheimer's Dementia 4 54.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
From its discovery in 1986 tetranectin (TN) has been suggested to participate in proteolytic processes through its binding to plasminogen, which enhances the activation of plasminogen to plasmin.
plasminogen Binding (binding) of tetranectin
1) Confidence 0.29 Published 1998 Journal APMIS Suppl. Section Abstract Doc Link 9868384 Disease Relevance 0.23 Pain Relevance 0
Besides plasminogen, tetranectin also specifically binds to the plasminogen-like hepatocyte growth factor and tPA, in a calcium dependent way, but does not interact with uPA.
plasminogen Binding (binds) of tetranectin in hepatocyte
2) Confidence 0.17 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2956083 Disease Relevance 0.35 Pain Relevance 0
Besides plasminogen, tetranectin also specifically binds to the plasminogen-like hepatocyte growth factor and tPA, in a calcium dependent way, but does not interact with uPA.
plasminogen Binding (binds) of tetranectin in hepatocyte
3) Confidence 0.17 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2956083 Disease Relevance 0.35 Pain Relevance 0
By binding to plasminogen, tetranectin may enhance activation of plasminogen to plasmin, which plays a role in the degradation of extracellular proteins and cancer progression.
plasminogen Binding (binding) of tetranectin associated with cancer
4) Confidence 0.16 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2956083 Disease Relevance 1.21 Pain Relevance 0
Tetranectin binds specifically to the kringle 4 domain of plasminogen, which is a circulating zymogen [51].
plasminogen Binding (binds) of Tetranectin
5) Confidence 0.16 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2956083 Disease Relevance 1.04 Pain Relevance 0

General Comments

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