INT79166

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Context Info
Confidence 0.44
First Reported 1998
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 12
Total Number 15
Disease Relevance 9.42
Pain Relevance 8.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (TNC) extracellular space (TNC) extracellular region (TNC)
cell adhesion (TNC)
Anatomy Link Frequency
nerve 1
extracellular matrix 1
TNC (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 423 100.00 Very High Very High Very High
Trigeminal neuralgia 208 100.00 Very High Very High Very High
carbamazepine 854 99.62 Very High Very High Very High
Gabapentin 65 99.38 Very High Very High Very High
carpal tunnel syndrome 5 99.28 Very High Very High Very High
Analgesic 56 99.06 Very High Very High Very High
fifth nerve 20 96.78 Very High Very High Very High
Multiple sclerosis 17 95.24 Very High Very High Very High
depression 12 94.52 High High
trigger zone 9 93.04 High High
Disease Link Frequency Relevance Heat
Pain 446 100.00 Very High Very High Very High
Neuralgia 207 100.00 Very High Very High Very High
Headache 9 100.00 Very High Very High Very High
Residual Neoplasm 2 99.80 Very High Very High Very High
Carpal Tunnel Syndrome 5 99.28 Very High Very High Very High
Psychosis 47 98.24 Very High Very High Very High
Cancer 132 97.76 Very High Very High Very High
Breast Cancer 10 96.48 Very High Very High Very High
Pathologic Constriction 1 96.12 Very High Very High Very High
Ovarian Cancer 6 95.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To clarify the role of tenascin-C and PG-M/versican, which have often been found to be involved in tissue remodeling and vascular stenosis in the pathogenesis of CTS, we histologically and biochemically examined the production of extracellular matrix in the flexor tenosynovium from 40 idiopathic CTS patients.
Regulation (role) of tenascin-C in extracellular matrix associated with pathologic constriction and carpal tunnel syndrome
1) Confidence 0.44 Published 2006 Journal Histol. Histopathol. Section Abstract Doc Link 16493581 Disease Relevance 0.71 Pain Relevance 0.46
Gender, American Society of Anesthesiologists (ASA) physical status, and length of treatment for TN was approximately the same in both groups, and a similar utilization of preoperative medications to control TN symptoms were used (Table 1).
Regulation (control) of TN associated with trigeminal neuralgia
2) Confidence 0.39 Published 2008 Journal Head Face Med Section Body Doc Link PMC2474589 Disease Relevance 0.53 Pain Relevance 0.32
The hospital should encourage the patients to contact their GP for further support".
Regulation (contact) of GP
3) Confidence 0.25 Published 2006 Journal BMC Fam Pract Section Body Doc Link PMC1435903 Disease Relevance 0.57 Pain Relevance 0.08
In conjunction with CA 125 and CASA the predictive value of TN for residual tumor was greatly improved, as the markers were found to supplement each other.
Regulation (value) of TN associated with residual neoplasm
4) Confidence 0.23 Published 1998 Journal APMIS Suppl. Section Abstract Doc Link 9868384 Disease Relevance 0.74 Pain Relevance 0
The qualitative analysis revealed that the following organizational and environmental factors influence GP practice in various ways: mode of remuneration, peer-to-peer interactions, patients' demands and the availability of other medical resources in the environment.
Regulation (influence) of GP
5) Confidence 0.22 Published 2008 Journal BMC Fam Pract Section Body Doc Link PMC2263046 Disease Relevance 0 Pain Relevance 0
Previous studies also indicated that combinations of CBZ + gabapentin or gabapentin + lamotrigine18 can result in TN pain control.
Regulation (control) of TN associated with pain, trigeminal neuralgia, gabapentin and carbamazepine
6) Confidence 0.19 Published 2010 Journal Journal of pain research Section Body Doc Link PMC3004633 Disease Relevance 0.54 Pain Relevance 1.40
The research question was formulated as follows: what variables influence the GP when he or she is caring for patients with psychoses in the acute and chronic phase?


Regulation (influence) of GP associated with psychosis
7) Confidence 0.13 Published 2007 Journal BMC Fam Pract Section Body Doc Link PMC1933537 Disease Relevance 0.74 Pain Relevance 0.05
CBZ is established as the first-line drug choice for pain control in TN.
Regulation (control) of TN associated with pain, trigeminal neuralgia and carbamazepine
8) Confidence 0.08 Published 2010 Journal Journal of pain research Section Body Doc Link PMC3004633 Disease Relevance 0.74 Pain Relevance 1.38
This is accompanied with a clear decrease in the daily CBZ dosage needed for TN pain control, with a consequent potential reduction in the adverse side effects associated.
Regulation (control) of TN associated with pain, trigeminal neuralgia and carbamazepine
9) Confidence 0.08 Published 2010 Journal Journal of pain research Section Body Doc Link PMC3004633 Disease Relevance 0.64 Pain Relevance 1.45
Neuropathic pain is a form of pain caused by a lesion or disease of the peripheral or central nervous system.1,2 It is a challenging condition to treat because of the following reasons: i) the heterogeneity of etiologies, symptoms, and underlying mechanisms; ii) poor response to conventional analgesics; and iii) the tendency for treatment being performed in a uniform fashion across the patient population.3 Trigeminal neuralgia (TN) (annual incidence of 4–5/100,000)4 is a type of neuropathy characterized by periods of intense paroxystic pain, usually of short duration and triggered by innocuous stimuli, although resulting in excruciating pain.5,6 A large number of cases of TN are idiopathic (primary or asymptomatic TN), usually with no detectable structural nerve lesion (includes the potential vascular compression of the fifth nerve in 15% of these patients) and a normal neurological evaluation.7,8 Like in other neuropathies, classic analgesics most frequently have no beneficial effects in controlling TN pain, even in secondary (symptomatic) TN, when it is associated with identifiable structural lesions, like a tumor or multiple sclerosis.
Regulation (controlling) of TN in nerve associated with pain, analgesic, trigeminal neuralgia, neuropathic pain, disease, fifth nerve, multiple sclerosis, cancer and central nervous system
10) Confidence 0.08 Published 2010 Journal Journal of pain research Section Body Doc Link PMC3004633 Disease Relevance 1.43 Pain Relevance 1.75
And the patient has complete confidence in the GP's control of what will happen onwards."
Regulation (control) of GP
11) Confidence 0.08 Published 2008 Journal BMC Health Serv Res Section Body Doc Link PMC2435108 Disease Relevance 0.07 Pain Relevance 0
We found that SI and SII activations in patients did neither depend on the affected side of TN nor differ between operated and nonoperated patients.
Regulation (affected) of TN associated with trigeminal neuralgia
12) Confidence 0.06 Published 2009 Journal Hum Brain Mapp Section Abstract Doc Link 19365802 Disease Relevance 1.14 Pain Relevance 1.25
RESULTS: In carbon dioxide studies in men, morphine reduced Gc from 1.61 +/- 0.33 to 1.23 +/- 0.12 l x min(-1) x mmHg(-1) (P < 0.05) without affecting Gp (control, 0.41 +/- 0.16 and morphine, 0.49 +/- 0.12 l x min(-1) x mmHg(-1), not significant).
Neg (without) Regulation (affecting) of Gp
13) Confidence 0.05 Published 1999 Journal Anesthesiology Section Body Doc Link 10319781 Disease Relevance 0.07 Pain Relevance 0
Morphine-induced changes in Gc were equal in men and women; changes in Gp were greater in women.
Regulation (changes) of Gp
14) Confidence 0.04 Published 1999 Journal Anesthesiology Section Body Doc Link 10319781 Disease Relevance 0.05 Pain Relevance 0
GP was responsible for carrying out the genotyping assays while NBK performed the lipid analysis.
Regulation (responsible) of GP
15) Confidence 0.03 Published 2008 Journal Lipids Health Dis Section Body Doc Link PMC2556320 Disease Relevance 1.36 Pain Relevance 0

General Comments

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