INT79168

Context Info Confidence 0.47 First Reported 1998 Last Reported 2010 Negated 5 Speculated 3 Reported most in Body Documents 39 Total Number 42 Disease Relevance 16.51 Pain Relevance 7.55

signal transduction (TNC) extracellular space (TNC) extracellular region (TNC) cell adhesion (TNC)

Anatomy Link Frequency tendon 2 finger 1 B12 1 blood cells 1 TNC (Homo sapiens)

Pain Link Frequency Relevance Heat Trigeminal neuralgia 64 100.00 carbamazepine 221 99.96 Gabapentin 16 99.58 abdominal pain 1 99.28 backache 7 99.20 Pain 338 98.68 depression 283 98.60 local anesthetic 3 95.96 Analgesic 22 93.84 fifth nerve 9 92.88

Disease Link Frequency Relevance Heat Headache 102 100.00 Neuralgia 49 100.00 Psychosis 67 99.80 Disease 110 99.78 Cancer 430 99.62 Abdominal Pain 1 99.28 Low Back Pain 7 99.20 Recurrence 31 99.12 Tendinopathy 8 99.08 Pain 284 98.68

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Sequence variants within the type V collagen (COL5A1) and tenascin C (TNC) genes have to date been shown to be associated with chronic Achilles tendinopathies and/or spontaneous Achilles tendon ruptures.

tenascin C Binding (associated) of in tendon associated with rupture and tendinopathy

1) Confidence 0.47 Published 2009 Journal J Sci Med Sport Section Abstract Doc Link 18353721 Disease Relevance 0.33 Pain Relevance 0.07

Sequence variants within the type V collagen (COL5A1) and tenascin C (TNC) genes have to date been shown to be associated with chronic Achilles tendinopathies and/or spontaneous Achilles tendon ruptures.

TNC Binding (associated) of in tendon associated with rupture and tendinopathy

2) Confidence 0.47 Published 2009 Journal J Sci Med Sport Section Abstract Doc Link 18353721 Disease Relevance 0.33 Pain Relevance 0.07

CONCLUSIONS: Chiari's malformation and hydrocephalus are rare associates of TN.

TN Binding (associates) of

3) Confidence 0.35 Published 2005 Journal Surg Neurol Section Body Doc Link 15936398 Disease Relevance 0.24 Pain Relevance 0

From its discovery in 1986 tetranectin (TN) has been suggested to participate in proteolytic processes through its binding to plasminogen, which enhances the activation of plasminogen to plasmin.

TN Binding (binding) of

4) Confidence 0.30 Published 1998 Journal APMIS Suppl. Section Abstract Doc Link 9868384 Disease Relevance 0.23 Pain Relevance 0

This study is designed to identify anatomical characteristics of NVC associated with TN.

TN Binding (associated) of associated with trigeminal neuralgia

5) Confidence 0.30 Published 2009 Journal J. Neurosurg. Section Abstract Doc Link 19338397 Disease Relevance 0.36 Pain Relevance 0.51

Also in line with our findings, these studies emphasize that continuous contact with the GP can be maintained by referring the patients back to their GPs after hospitalization, by ensuring good communication between specialists and GPs and by providing a clear definition of the GP's role [26].

GP Spec (clear) Binding (definition) of

6) Confidence 0.28 Published 2008 Journal BMC Palliat Care Section Body Doc Link PMC2254378 Disease Relevance 0.11 Pain Relevance 0.21

They appreciated the continuity the GP provided, i.e. the GP's acquaintance with the patient and the relatives both before and after the cancer diagnosis and the GP's knowledge of the specific course of disease.

GP Binding (knowledge) of associated with cancer and disease

7) Confidence 0.28 Published 2008 Journal BMC Palliat Care Section Body Doc Link PMC2254378 Disease Relevance 0.36 Pain Relevance 0.23

They appreciated the continuity the GP provided, i.e. the GP's acquaintance with the patient and the relatives both before and after the cancer diagnosis and the GP's knowledge of the specific course of disease.

GP Binding (acquaintance) of associated with cancer and disease

8) Confidence 0.28 Published 2008 Journal BMC Palliat Care Section Body Doc Link PMC2254378 Disease Relevance 0.36 Pain Relevance 0.24

The GP was informed in writing of the evaluation, and asked to implement the recommendations regarding medication changes.

GP Spec (asked) Binding (implement) of

9) Confidence 0.27 Published 2005 Journal Ann Gen Psychiatry Section Body Doc Link PMC1318453 Disease Relevance 0.39 Pain Relevance 0

The GP and the specialist should work together

GP Binding (work) of

10) Confidence 0.20 Published 2006 Journal BMC Fam Pract Section Body Doc Link PMC1435903 Disease Relevance 0.29 Pain Relevance 0.07

Two patients did not feel safe with their personal GP; one of them saw the GP once more and talked it through with him and ended up with trusting the GP, the other chose another GP.

GP Neg (not) Binding (feel) of

11) Confidence 0.20 Published 2006 Journal BMC Fam Pract Section Body Doc Link PMC1435903 Disease Relevance 0.31 Pain Relevance 0

Similarly, the immediate project team is not blind to GP participant status as much interaction between the team and the GPs must occur as part of the training and organising for women to attend their counselling appointments.

GP Binding (interaction) of

12) Confidence 0.15 Published 2010 Journal BMC Public Health Section Body Doc Link PMC2823699 Disease Relevance 0 Pain Relevance 0

When the GP recognizes the psychosis and the patient allows himself to be referred to a psychiatrist, the GP becomes a concerned observer.

GP Binding (recognizes) of associated with psychosis

13) Confidence 0.15 Published 2007 Journal BMC Fam Pract Section Body Doc Link PMC1933537 Disease Relevance 0.65 Pain Relevance 0.03

A similar approach has resulted in improved efficacy when using gabapentin in the treatment of TN.21 The protocol associating CBZ + ROP resulted in a significant reduction in i) pain intensity, ii) the number of daily pain crises, and iii) the daily dose of CBZ intake, when compared with the traditional CBZ protocol in monotherapy.

TN Binding (associating) of associated with pain, trigeminal neuralgia, gabapentin and carbamazepine

14) Confidence 0.11 Published 2010 Journal Journal of pain research Section Body Doc Link PMC3004633 Disease Relevance 0.69 Pain Relevance 1.70

For example, DP06w and DP05m explained how having a friendship with their GP made it very difficult to discuss depression, while DP07m felt he did not want his longstanding psychoanalyst to see him in a deep depression, perhaps because of his pride:-

GP Binding (friendship) of associated with depression

15) Confidence 0.11 Published 2007 Journal BMC Fam Pract Section Body Doc Link PMC1941733 Disease Relevance 0.47 Pain Relevance 0.17

METHODS: The authors analyzed 144 consecutive cases involving patients who underwent MVD for TN.

TN Spec (analyzed) Binding (underwent) of

16) Confidence 0.10 Published 2009 Journal J. Neurosurg. Section Body Doc Link 19392593 Disease Relevance 0.19 Pain Relevance 0

We provided all participants with free medical advice and assisted in finding a GP.

GP Binding (finding) of

17) Confidence 0.08 Published 2010 Journal Int J Public Health Section Body Doc Link PMC2941053 Disease Relevance 0 Pain Relevance 0

GP: "I think that the GP should be a kind of anchor person for the patient."

GP Binding (kind) of

18) Confidence 0.07 Published 2008 Journal BMC Health Serv Res Section Body Doc Link PMC2435108 Disease Relevance 0.12 Pain Relevance 0

These differences were most prominent for finger stimulation, an area not associated with TN.

TN Binding (associated) of in finger associated with trigeminal neuralgia

19) Confidence 0.07 Published 2009 Journal Hum Brain Mapp Section Abstract Doc Link 19365802 Disease Relevance 1.08 Pain Relevance 1.25

If the patient's TN types 1 and 2 (typical or atypical TN) is associated with a mass lesion of the cerebellopontine angle, the surgery should address the mass lesion and the pain is expected to improve once the mass lesion is eliminated.

TN Binding (associated) of associated with pain

20) Confidence 0.07 Published 2007 Journal Head Face Med Section Body Doc Link PMC1976607 Disease Relevance 1.23 Pain Relevance 0.93

General Comments

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