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Context Info
Confidence 0.03
First Reported 1998
Last Reported 2001
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 2.11
Pain Relevance 1.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (B2M) plasma membrane (B2M)
Anatomy Link Frequency
B2M (Homo sapiens)
Pain Link Frequency Relevance Heat
Paracetamol 11 99.32 Very High Very High Very High
Pain 1 99.12 Very High Very High Very High
palliative 1 65.84 Quite High
Analgesic 2 65.20 Quite High
pruritus 1 60.12 Quite High
Disease Link Frequency Relevance Heat
Balkan Nephropathy 6 99.32 Very High Very High Very High
Renal Disease 8 99.00 Very High Very High Very High
Skin Cancer 6 97.96 Very High Very High Very High
Cancer 2 95.28 Very High Very High Very High
Amyloidosis 5 91.68 High High
Ecchymosis 1 60.60 Quite High
Pruritus 1 60.12 Quite High
Disease 3 46.68 Quite Low
Nephrotoxicity 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Phase II study of direct intralesional gene transfer of allovectin-7, an HLA-B7/beta2-microglobulin DNA-liposome complex, in patients with metastatic melanoma.
Positive_regulation (transfer) of Gene_expression (transfer) of beta2-microglobulin associated with pain and skin cancer
1) Confidence 0.03 Published 2001 Journal Clin. Cancer Res. Section Title Doc Link 11489803 Disease Relevance 0.65 Pain Relevance 0.13
However, acetaminophen treatment produced a significant increase in beta 2-microglobulin excretion in patient with BEN and GN, and in clinically healthy members of nephropathic families.
Positive_regulation (increase) of Gene_expression (excretion) of 2-microglobulin in BEN associated with paracetamol, renal disease and balkan nephropathy
2) Confidence 0.02 Published 1999 Journal Ren Fail Section Abstract Doc Link 10516997 Disease Relevance 1.06 Pain Relevance 0.82
Other potential but more controversial explanations include a protective influence on residual renal function, a lower stimulation of beta2-microglobulin synthesis or release, or a beneficial influence on advanced glycosylation end (AGE) products.
Positive_regulation (stimulation) of Gene_expression (synthesis) of beta2-microglobulin
3) Confidence 0.01 Published 1998 Journal Nephrol. Dial. Transplant. Section Abstract Doc Link 9870440 Disease Relevance 0.40 Pain Relevance 0.13

General Comments

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