INT79196

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Context Info
Confidence 0.39
First Reported 1999
Last Reported 2003
Negated 3
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.50
Pain Relevance 2.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ntsr1) plasma membrane (Ntsr1) signal transducer activity (Ntsr1)
Ntsr1 (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 4 100.00 Very High Very High Very High
analgesia 9 98.56 Very High Very High Very High
Neuropeptide 4 95.84 Very High Very High Very High
Intracerebroventricular 3 92.32 High High
Analgesic 8 89.68 High High
tetrodotoxin 1 89.36 High High
Potency 1 88.88 High High
agonist 2 81.76 Quite High
Glutamate 2 78.16 Quite High
narcan 1 76.92 Quite High
Disease Link Frequency Relevance Heat
Body Weight 2 95.60 Very High Very High Very High
Hypothermia 2 91.80 High High
Congenital Anomalies 2 74.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
NT-1R(-/-) mice showed similar spontaneous locomotion to the control littermates, but did not respond to i.c.v.
Neg (not) Regulation (respond) of NT-1R
1) Confidence 0.39 Published 2002 Journal Brain Res. Section Abstract Doc Link 12384239 Disease Relevance 0.26 Pain Relevance 0.39
However, neither an NTR1 antagonist, SR48692, an NTR2 antagonist, levocabastine, nor the two combined affected the basal level and the neurotensin-mediated decrease in DARPP-32 Thr75 phosphorylation.
Regulation (affected) of NTR1 associated with antagonist
2) Confidence 0.39 Published 2003 Journal Eur. J. Neurosci. Section Abstract Doc Link 12956723 Disease Relevance 0 Pain Relevance 0.44
I.c.v. injection of NT inhibited feeding in fasted wild-type mice, but had no effect on feeding of the NT-1R(-/-) mice.
Neg (no) Regulation (effect) of NT-1R
3) Confidence 0.27 Published 2002 Journal Brain Res. Section Abstract Doc Link 12384239 Disease Relevance 0.24 Pain Relevance 0.39
This effect was specific, because NTR1 levels were unaffected, and sense or scramble oligodeoxynucleotides had no effect.
Neg (unaffected) Regulation (unaffected) of NTR1
4) Confidence 0.25 Published 1999 Journal J. Neurosci. Section Abstract Doc Link 9870978 Disease Relevance 0 Pain Relevance 0.79

General Comments

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