INT7920

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Context Info
Confidence 0.27
First Reported 1986
Last Reported 2008
Negated 2
Speculated 3
Reported most in Abstract
Documents 26
Total Number 31
Disease Relevance 3.64
Pain Relevance 19.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Akr1d1) oxidoreductase activity (Akr1d1) cytoplasm (Akr1d1)
Anatomy Link Frequency
striatum 4
brain 3
nucleus accumbens 1
shell 1
neuronal 1
Akr1d1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 281 100.00 Very High Very High Very High
substance P 36 100.00 Very High Very High Very High
dopamine receptor 35 100.00 Very High Very High Very High
narcan 32 100.00 Very High Very High Very High
antagonist 76 99.98 Very High Very High Very High
Opioid 6 99.98 Very High Very High Very High
opiate 17 99.84 Very High Very High Very High
agonist 140 99.82 Very High Very High Very High
Analgesic 6 99.54 Very High Very High Very High
Serotonin 3 99.42 Very High Very High Very High
Disease Link Frequency Relevance Heat
Schizophrenia 75 99.16 Very High Very High Very High
Hypertension 27 99.12 Very High Very High Very High
Cognitive Disorder 9 90.64 High High
Natriuresis 6 83.36 Quite High
Diuresis 6 82.84 Quite High
Attention Deficit Hyperactivity Disorder 15 80.64 Quite High
Urological Neuroanatomy 3 71.20 Quite High
Akathisia 3 64.52 Quite High
Mental Disorders 6 64.24 Quite High
Overactive Bladder 3 62.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effects of acute and chronic administration of the opioid antagonist, nalmefene, on the binding activity of [11C]SCH23390 and [11C]N-methylspiperone at D1 and D2 dopamine receptors, respectively, was investigated in the rat.
D1 Binding (binding) of associated with dopamine receptor, antagonist and opioid
1) Confidence 0.27 Published 1997 Journal Brain Res. Section Abstract Doc Link 9439841 Disease Relevance 0 Pain Relevance 0.57
Representative examples of this behavior measured during protraction of D1 and D3 whiskers on a P150 sandpaper are shown in Figure 9A (see also Figure 7A and 7B).
D1 Binding (protraction) of in whiskers
2) Confidence 0.19 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2525689 Disease Relevance 0 Pain Relevance 0
In the present study, we therefore examined interactions between D1 dopamine receptors and the (+/-)-alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate/kainate subtypes of glutamate receptor by determining whether striatal infusion of the (+/-)-alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate/kainate antagonist 6-cyano-7-nitroquinoxaline-2,3-dione would block D1 receptor-mediated induction of the immediate early genes c-fos and zif268 in the dopamine-depleted striatum.
D1 Spec (examined) Binding (interactions) of in striatum associated with dopamine, antagonist, glutamate receptor and dopamine receptor
3) Confidence 0.09 Published 1999 Journal Neuroscience Section Abstract Doc Link 10077330 Disease Relevance 0 Pain Relevance 0.60
These latter results suggest that there is an interaction between D1 and D2 receptors whereby the effects of dopamine mediated via D1 sites are inhibited by an action on D2 sites.
D1 Binding (interaction) of associated with dopamine
4) Confidence 0.07 Published 1997 Journal Neuroscience Section Abstract Doc Link 9472401 Disease Relevance 0 Pain Relevance 0.95
Influence of dopamine on GABA release in striatum: evidence for D1-D2 interactions and non-synaptic influences.
D1 Binding (interactions) of in striatum associated with gaba and dopamine
5) Confidence 0.05 Published 1997 Journal Neuroscience Section Title Doc Link 9472401 Disease Relevance 0 Pain Relevance 0.83
In conclusion, our results suggest that (i) dopamine agonists can exert an excitatory influence on depolarization-induced GABA release within neostriatum via D1 receptors and an inhibitory influence via D2 receptors; (ii) under the conditions of these experiments, endogenous dopamine fails to act on D1 sites but does exert an inhibitory influence via D2 sites; and (iii) there is an interaction between D1 and D2 receptors such that the actions of dopamine mediated via D1 sites are inhibited as a result of the concomitant actions exerted via D2 sites.
D1 Binding (act) of associated with gaba, dopamine and agonist
6) Confidence 0.05 Published 1997 Journal Neuroscience Section Abstract Doc Link 9472401 Disease Relevance 0 Pain Relevance 0.68
In conclusion, our results suggest that (i) dopamine agonists can exert an excitatory influence on depolarization-induced GABA release within neostriatum via D1 receptors and an inhibitory influence via D2 receptors; (ii) under the conditions of these experiments, endogenous dopamine fails to act on D1 sites but does exert an inhibitory influence via D2 sites; and (iii) there is an interaction between D1 and D2 receptors such that the actions of dopamine mediated via D1 sites are inhibited as a result of the concomitant actions exerted via D2 sites.
D1 Binding (interaction) of associated with gaba, dopamine and agonist
7) Confidence 0.05 Published 1997 Journal Neuroscience Section Abstract Doc Link 9472401 Disease Relevance 0 Pain Relevance 0.64
These results further indicate that displacement of SCH 23390 in the ligand binding test reflects affinity of a compound for D1 and DA1 dopamine receptors.
D1 Binding (affinity) of associated with dopamine receptor
8) Confidence 0.05 Published 1986 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2878816 Disease Relevance 0.05 Pain Relevance 0.24
The present study was conducted to investigate the effects of repeated administration of opiates on the binding characteristics of D1 and D2 dopamine receptors in specific rat brain regions.
D1 Binding (binding) of in brain associated with dopamine receptor and opiate
9) Confidence 0.05 Published 1995 Journal Pharmacology Section Abstract Doc Link 8584575 Disease Relevance 0 Pain Relevance 0.37
Amperozide is an atypical antipsychotic drug with high affinity for the serotonin 5-HT2 receptor but with low affinity for the dopamine D1 and D2 receptors.
D1 Binding (affinity) of associated with dopamine and serotonin
10) Confidence 0.04 Published 1992 Journal Life Sci. Section Abstract Doc Link 1359366 Disease Relevance 0 Pain Relevance 0.40
The phenothiazines, chlorpromazine and fluphenazine, bind to both D1 and D2 dopamine receptors and effectively compete with [3H]TAM for binding at the AEBS.
D1 Binding (bind) of associated with dopamine receptor
11) Confidence 0.04 Published 1992 Journal Brain Res. Section Abstract Doc Link 1511289 Disease Relevance 0 Pain Relevance 0.44
Alteration of D1 and D2 dopaminergic receptor kinetics in specific rat brain regions following repeated administration of opiates.
D1 Binding (Alteration) of in brain associated with narcan and opiate
12) Confidence 0.03 Published 1995 Journal Pharmacology Section Title Doc Link 8584575 Disease Relevance 0.37 Pain Relevance 0.60
It is concluded that repeated intermittent treatment with opiates induces alterations in D1 and D2 dopamine receptors binding properties and that these changes are regionally specific.
D1 Binding (binding) of associated with dopamine receptor and opiate
13) Confidence 0.03 Published 1995 Journal Pharmacology Section Abstract Doc Link 8584575 Disease Relevance 0 Pain Relevance 1.37
The result indicated that the SP fragment elicited a significant decrease in specific binding to D1-like receptors in the caudate putamen, nucleus accumbens shell, nucleus accumbens core, substantia nigra and medial globus pallidus.
D1 Spec (like) Binding (binding) of in nucleus accumbens associated with nucleus accumbens, substantia nigra and substance p
14) Confidence 0.03 Published 2004 Journal Peptides Section Abstract Doc Link 15501527 Disease Relevance 0.07 Pain Relevance 1.64
By combining c-fos (radioactive) in situ hybridization histochemistry with nonradioactive in situ hybridization histochemistry for mRNAs encoding other striatal markers [preprotachykinin (substance P), proenkephalin, and D1 and D2 receptors], we have identified the cellular phenotype of striatal neurons activated by acute administration of cocaine to P8, P15, P28, and adult rats.
D1 Binding (combining) of in neurons associated with cocaine and substance p
15) Confidence 0.03 Published 1995 Journal J. Comp. Neurol. Section Abstract Doc Link 7534774 Disease Relevance 0 Pain Relevance 0.40
The antagonist SK&F 83566 interacted with D1 receptors in the manner of a competitive antagonist, causing a decrease in the affinity of the binding of [3H]SCH 23390, without altering the maximum number of binding sites (Bmax).
D1 Binding (interacted) of associated with antagonist
16) Confidence 0.03 Published 1992 Journal Neuropharmacology Section Abstract Doc Link 1532443 Disease Relevance 0 Pain Relevance 0.54
Agonist and antagonist interactions with D1 dopamine receptors: agonist-induced masking of D1 receptors depends on intrinsic activity.
D1 Binding (interactions) of associated with dopamine receptor, antagonist and agonist
17) Confidence 0.03 Published 1992 Journal Neuropharmacology Section Title Doc Link 1532443 Disease Relevance 0 Pain Relevance 0.74
However, agonists with moderate (SK&F 38393, CY 208-243) or full (dopamine) intrinsic activity to stimulate adenylate cyclase, interacted with D1 binding sites in a mixed competitive/non-competitive manner, causing both a decrease in ligand affinity and a decrease in Bmax.
D1 Binding (interacted) of associated with dopamine and agonist
18) Confidence 0.03 Published 1992 Journal Neuropharmacology Section Abstract Doc Link 1532443 Disease Relevance 0 Pain Relevance 0.64
In the present study, we have applied autoradiography to investigate the effect of the heptapeptide on the binding of dopamine D1- and D2-receptors in mesocorticolimbic brain areas of male rats during morphine withdrawal.
D1 Binding (binding) of in brain associated with dopamine, withdrawal and morphine
19) Confidence 0.03 Published 2004 Journal Peptides Section Abstract Doc Link 15501527 Disease Relevance 0 Pain Relevance 1.53
Agonist and antagonist interactions with D1 dopamine receptors: agonist-induced masking of D1 receptors depends on intrinsic activity.
D1 Binding (masking) of associated with dopamine receptor, antagonist and agonist
20) Confidence 0.02 Published 1992 Journal Neuropharmacology Section Title Doc Link 1532443 Disease Relevance 0 Pain Relevance 0.74

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