INT79212

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Context Info
Confidence 0.67
First Reported 1998
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 5
Total Number 7
Disease Relevance 2.32
Pain Relevance 0.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ccnd2) nucleolus (Ccnd2) nucleus (Ccnd2)
cell division (Ccnd2) cellular_component (Ccnd2) cytoplasm (Ccnd2)
Anatomy Link Frequency
follicles 2
muscle tissue 1
sciatic nerve 1
satellite cells 1
Ccnd2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
vincristine 3 100.00 Very High Very High Very High
Dorsal horn neuron 1 96.64 Very High Very High Very High
Peripheral nerve injury 1 95.40 Very High Very High Very High
Eae 6 92.92 High High
Sciatic nerve 2 91.28 High High
agonist 9 85.24 High High
withdrawal 3 60.88 Quite High
Dorsal horn 1 60.56 Quite High
Neuropathic pain 1 25.00 Low Low
cytokine 17 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Retinoblastoma 12 99.40 Very High Very High Very High
Adhesions 4 97.36 Very High Very High Very High
Infection 84 97.04 Very High Very High Very High
Nervous System Injury 2 94.96 High High
Injury 33 92.08 High High
Stress 21 89.80 High High
Apoptosis 107 81.08 Quite High
Hyperplasia 1 63.44 Quite High
Shock 14 63.36 Quite High
Ovarian Cancer 9 58.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effect of vincristine (Vin, a fast axonal transport blocker) to prevent any alteration in the excitability of dorsal horn neurons, following peripheral nerve injury, was investigated on 31 rats: 20 with chronic constriction injury (CCI) of the sciatic nerve and 11 sham preparations.
Spec (investigated) Gene_expression (effect) of Vin in sciatic nerve associated with vincristine, nervous system injury, eae, injury, sciatic nerve, dorsal horn neuron and peripheral nerve injury
1) Confidence 0.67 Published 1998 Journal J. Neurotrauma Section Abstract Doc Link 9872464 Disease Relevance 0.49 Pain Relevance 0.45
The 40% CR females on the other hand, show a decrease in Ccnd2 expression.
Gene_expression (expression) of Ccnd2
2) Confidence 0.59 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2607546 Disease Relevance 0.06 Pain Relevance 0
In the ovary, ccnd2 is expressed in the granulosa cells of the follicles and has been shown to play an important role in folliculogenesis.
Gene_expression (expressed) of ccnd2 in follicles
3) Confidence 0.52 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2607546 Disease Relevance 0.19 Pain Relevance 0
, cyclin D2 is expressed in granulosa cells of developing follicles and down-regulated within 4 hours of the LH surge, but only in follicles that responded to the gonadotropin surge [130].
Gene_expression (expressed) of cyclin D2 in follicles
4) Confidence 0.06 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1266036 Disease Relevance 0.58 Pain Relevance 0.04
It was found that in Trichinella infected muscle, expression of IGF-I, IGF-I receptor, IGFBPs, MAP kinase kinase, cyclin D2, cyclin D3, CDK4 and c-jun were up-regulated [9,11], suggesting that IGF-I likely plays role in the proliferation of satellite cells and cell cycle reentry of infected muscle cell during nurse cell formation through MAP kinase signaling (Fig 3).
Gene_expression (expression) of cyclin D2 in satellite cells
5) Confidence 0.02 Published 2008 Journal Parasit Vectors Section Body Doc Link PMC2538513 Disease Relevance 0.06 Pain Relevance 0
Therefore, increased expression of cyclin D2, cyclin D3 and CDK4 is probably involved in the cell cycle reentry after infection.
Gene_expression (expression) of cyclin D2 associated with infection
6) Confidence 0.02 Published 2008 Journal Parasit Vectors Section Body Doc Link PMC2538513 Disease Relevance 0.47 Pain Relevance 0.03
As shown in Table 3, expression change of many cell cycle-related factors was observed in Trichinella infected muscle tissue, for example, retinoblastoma (Rb), CDK4, cyclin C, cyclin B2, cyclin D2 and cyclin D3, CLU, G0/G1 switch gene 2 (G0S2), inhibitor of DNA binding 2 (Id2), myeloblastosis oncogene (Myb), and N-myc downstream regulated gene 2 (Ndrg2) [9,11].
Gene_expression (/) of cyclin D2 in muscle tissue associated with retinoblastoma
7) Confidence 0.01 Published 2008 Journal Parasit Vectors Section Body Doc Link PMC2538513 Disease Relevance 0.46 Pain Relevance 0

General Comments

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