INT79227

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Context Info
Confidence 0.59
First Reported 1998
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 45
Total Number 45
Disease Relevance 41.65
Pain Relevance 14.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Icam1) cell adhesion (Icam1) plasma membrane (Icam1)
Anatomy Link Frequency
monocyte 10
brain 6
neutrophils 6
macrophages 4
leukocyte 4
Icam1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 780 100.00 Very High Very High Very High
ischemia 145 99.98 Very High Very High Very High
antagonist 82 99.98 Very High Very High Very High
cytokine 236 99.82 Very High Very High Very High
b2 receptor 17 99.76 Very High Very High Very High
licofelone 8 99.54 Very High Very High Very High
cINOD 101 99.36 Very High Very High Very High
isoflurane 40 99.36 Very High Very High Very High
rheumatoid arthritis 75 98.96 Very High Very High Very High
Arthritis 47 98.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 845 100.00 Very High Very High Very High
Injury 332 100.00 Very High Very High Very High
Disease 201 100.00 Very High Very High Very High
Adhesions 187 100.00 Very High Very High Very High
Pressure And Volume Under Development 29 100.00 Very High Very High Very High
Cv Unclassified Under Development 100 99.98 Very High Very High Very High
Multiple Sclerosis 153 99.96 Very High Very High Very High
Myocardial Infarction 95 99.92 Very High Very High Very High
Disorder Of Lipid Metabolism 750 99.84 Very High Very High Very High
Nicotine Addiction 109 99.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Rebamipide reduces indomethacin-induced gastric injury in mice via down-regulation of ICAM-1 expression.
Negative_regulation (down) of Gene_expression (expression) of ICAM-1 associated with injury
1) Confidence 0.59 Published 2005 Journal Dig. Dis. Sci. Section Title Doc Link 16184426 Disease Relevance 0.83 Pain Relevance 0.29
Furthermore, rebamipide pre-treatment notably decreased intercellular adhesion molecule-1 (ICAM-1) expression that was up-regulated in gastric tissue treated with indomethacin.
Negative_regulation (decreased) of Gene_expression (expression) of intercellular adhesion molecule-1 associated with adhesions
2) Confidence 0.59 Published 2005 Journal Dig. Dis. Sci. Section Abstract Doc Link 16184426 Disease Relevance 0.81 Pain Relevance 0.21
Cd-induced ICAM-1 expression and leukocyte-EC adhesion were diminished by non-steroidal anti-inflammatory drugs such as indomethacin and NS-398, which was reversed by addition of PGE(2).
Negative_regulation (diminished) of Gene_expression (expression) of ICAM-1 in leukocyte associated with inflammation, cinod and adhesions
3) Confidence 0.51 Published 2006 Journal Toxicol. Lett. Section Abstract Doc Link 16777358 Disease Relevance 0.36 Pain Relevance 0.10
This was accompanied by a decrease of the expression of ICAM-1 and an increase in HO-1 expression.
Negative_regulation (decrease) of Gene_expression (expression) of ICAM-1
4) Confidence 0.43 Published 2008 Journal International Journal of Biological Sciences Section Abstract Doc Link PMC2430988 Disease Relevance 0.63 Pain Relevance 0
Rebamipide reduces indomethacin-induced gastric injury in mice via down-regulation of ICAM-1 expression.
Negative_regulation (regulation) of Gene_expression (expression) of ICAM-1 associated with injury
5) Confidence 0.43 Published 2005 Journal Dig. Dis. Sci. Section Title Doc Link 16184426 Disease Relevance 0.83 Pain Relevance 0.29
Furthermore, rebamipide pre-treatment notably decreased intercellular adhesion molecule-1 (ICAM-1) expression that was up-regulated in gastric tissue treated with indomethacin.
Negative_regulation (decreased) of Gene_expression (expression) of ICAM-1 associated with adhesions
6) Confidence 0.43 Published 2005 Journal Dig. Dis. Sci. Section Abstract Doc Link 16184426 Disease Relevance 0.81 Pain Relevance 0.21
Discrepancies between sICAM-1 levels in different studies can be attributed to the racial/ ethnic differences in cardiovascular risk.1
Negative_regulation (Discrepancies) of Gene_expression (levels) of sICAM-1
7) Confidence 0.37 Published 2010 Journal Annals of Saudi Medicine Section Body Doc Link PMC2994157 Disease Relevance 1.52 Pain Relevance 0.25
Moreover, licofelone treatment (30 microM) attenuated expression of VCAM-1 and ICAM-1 on inflammatory EC.
Negative_regulation (attenuated) of Gene_expression (expression) of ICAM-1 associated with inflammation and licofelone
8) Confidence 0.37 Published 2005 Journal Biochem. Pharmacol. Section Abstract Doc Link 15894291 Disease Relevance 0.47 Pain Relevance 1.13
Together, these data suggest that Cd induces COX-2 expression through the activation of p38 MAPK, an oxidative stress-sensitive cellular signaling molecule, and induction of COX-2 is associated with ICAM-1 expression in brain endothelial cells following Cd exposure.
Negative_regulation (associated) of Gene_expression (expression) of ICAM-1 in brain associated with stress
9) Confidence 0.37 Published 2006 Journal Toxicol. Lett. Section Abstract Doc Link 16777358 Disease Relevance 0.34 Pain Relevance 0.09
B-regulated expression of Tnf, Il6, Ccl2, Ccl5, Cxcl10, and Icam1 [22] were significantly reduced in Tlr4 KO versus WT retinas, suggesting that the neuroprotective effect is in part due to Tlr4-NF-?
Negative_regulation (reduced) of Gene_expression (expression) of Icam1 in retinas
10) Confidence 0.36 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2956702 Disease Relevance 0.98 Pain Relevance 0.35
Mice subjected to renal IR under isoflurane anesthesia also showed a reduction in inflammation evidenced by a reduced renal influx of neutrophils and macrophages, reduced ICAM-1 expression, less upregulation of proinflammatory mRNAs (TNF-alpha, ICAM-1, KC, and IL-1beta) as well as reduced nuclear translocation of NF-kappaB 24 h after renal IR injury.
Negative_regulation (reduced) of Gene_expression (expression) of ICAM-1 in neutrophils associated with anesthesia, inflammation, injury and isoflurane
11) Confidence 0.34 Published 2007 Journal Am. J. Physiol. Renal Physiol. Section Abstract Doc Link 17596528 Disease Relevance 1.34 Pain Relevance 1.07
This observation is consistent with previous reports which showed that FPS combination decreased ICAM-1 expression in human lung fibroblast cells [33,34].
Negative_regulation (decreased) of Gene_expression (expression) of ICAM-1 in fibroblast
12) Confidence 0.34 Published 2006 Journal Virol J Section Body Doc Link PMC1488829 Disease Relevance 0.85 Pain Relevance 0.10
Treatment with the combination resulted in a decrease of ICAM-1 expression.
Negative_regulation (decrease) of Gene_expression (expression) of ICAM-1
13) Confidence 0.34 Published 2006 Journal Virol J Section Body Doc Link PMC1488829 Disease Relevance 0.99 Pain Relevance 0.11
Mice subjected to renal IR under isoflurane anesthesia also showed a reduction in inflammation evidenced by a reduced renal influx of neutrophils and macrophages, reduced ICAM-1 expression, less upregulation of proinflammatory mRNAs (TNF-alpha, ICAM-1, KC, and IL-1beta) as well as reduced nuclear translocation of NF-kappaB 24 h after renal IR injury.
Negative_regulation (reduced) of Gene_expression (expression) of ICAM-1 in neutrophils associated with anesthesia, inflammation, injury and isoflurane
14) Confidence 0.34 Published 2007 Journal Am. J. Physiol. Renal Physiol. Section Abstract Doc Link 17596528 Disease Relevance 1.27 Pain Relevance 1.01
ICAM-1 expression of the hepatic tissue was detected by an immunohistochemistry technique as previously published by our laboratory [13].
Negative_regulation (detected) of Gene_expression (expression) of ICAM-1
15) Confidence 0.32 Published 2007 Journal J Inflamm (Lond) Section Body Doc Link PMC1891280 Disease Relevance 0.16 Pain Relevance 0.03
In addition, treatment with a B2 receptor antagonist decreases CD44, CD54, CD11a and CD11b expression in various cell types after arthritis induction in Lewis rats [36].
Negative_regulation (decreases) of Gene_expression (expression) of CD54 associated with antagonist, b2 receptor and arthritis
16) Confidence 0.32 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2596102 Disease Relevance 1.52 Pain Relevance 0.82
In vivo administration of CORM-2, expression of ICAM-1 was significantly decreased (Fig. 4, A and C), while expression of HO-1 was more significantly increased compared to burn group (Fig. 4, A and B).
Negative_regulation (decreased) of Gene_expression (expression) of ICAM-1 associated with burns
17) Confidence 0.32 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2430988 Disease Relevance 1.44 Pain Relevance 0
Renal cortices of isoflurane-treated mice had significantly reduced expression of intercellular adhesion molecule 1, TNF-alpha, and IL-1beta messenger RNA and showed less apoptosis.
Negative_regulation (reduced) of Gene_expression (expression) of intercellular adhesion molecule 1 associated with isoflurane, apoptosis and adhesions
18) Confidence 0.31 Published 2007 Journal Shock Section Abstract Doc Link 17414419 Disease Relevance 1.35 Pain Relevance 0.93
In addition, we found that these proteasome inhibitors significantly reduced indomethacin-induced gastric mucosal injury as well as gastric mucosal ICAM-1 expression in the rat in vivo.
Negative_regulation (reduced) of Gene_expression (expression) of ICAM-1 associated with injury
19) Confidence 0.31 Published 1998 Journal J. Clin. Gastroenterol. Section Abstract Doc Link 9872503 Disease Relevance 0.43 Pain Relevance 0.21
Thus, previous reports demonstrated the reduction of ICAM-1 expression by therapeutic intervention, and it was concluded in the studies that this reduction resulted in attenuation of leukocyte adhesion and/or transmigration [35,39].
Negative_regulation (reduction) of Gene_expression (expression) of ICAM-1 in leukocyte associated with adhesions
20) Confidence 0.30 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2905642 Disease Relevance 0.94 Pain Relevance 0.13

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