INT7923

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Context Info
Confidence 0.72
First Reported 1992
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 14
Total Number 19
Disease Relevance 4.44
Pain Relevance 6.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Trh) plasma membrane (Trh) nucleus (Trh)
cytoplasm (Trh)
Anatomy Link Frequency
striatum 3
medial geniculate nucleus 2
habenulae 2
brain 1
nucleus 1
Trh (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Enkephalin 17 100.00 Very High Very High Very High
amygdala 8 100.00 Very High Very High Very High
Neuropeptide 7 100.00 Very High Very High Very High
Dynorphin 5 100.00 Very High Very High Very High
Central nervous system 10 99.96 Very High Very High Very High
Dopamine 295 99.68 Very High Very High Very High
substance P 22 99.48 Very High Very High Very High
Serotonin 15 99.00 Very High Very High Very High
withdrawal 8 98.44 Very High Very High Very High
Thalamus 5 98.12 Very High Very High Very High
Disease Link Frequency Relevance Heat
Convulsion 10 100.00 Very High Very High Very High
Starvation 10 98.82 Very High Very High Very High
Urological Neuroanatomy 12 97.28 Very High Very High Very High
Congenital Anomalies 18 97.08 Very High Very High Very High
Cognitive Disorder 5 96.40 Very High Very High Very High
Dyskinesias 204 96.16 Very High Very High Very High
Pain 5 93.28 High High
Disease 128 92.64 High High
Opiate Addiction 1 89.92 High High
Tremor 12 86.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These findings suggest that preproTRH transcription is strongly and specifically up-regulated in the dopamine-depleted striatum by L-DOPA treatment, and that this up-regulation is accompanied by the appearance of some level of abnormal movements in the animals.
Transcription (transcription) of preproTRH in striatum associated with dopamine and dyskinesias
1) Confidence 0.72 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2978093 Disease Relevance 0.43 Pain Relevance 0.21
Changes in the mRNA levels of proTRH and proenkephalin were quantified by in situ hybridization in rats administered ethanol intragastrically (2.5 g/kg).
Transcription (levels) of proTRH
2) Confidence 0.72 Published 2000 Journal Neurochem. Int. Section Abstract Doc Link 10871700 Disease Relevance 0.46 Pain Relevance 0.34
In contrast to the very restricted mRNA expression of TRH-R1 in the central nervous system, TRH-R2 mRNA was widely distributed with highest transcript levels throughout the thalamus, in the cerebral and cerebellar cortex, medial habenulae, medial geniculate nucleus, pontine nuclei, and throughout the reticular formation.
Transcription (expression) of TRH in habenulae associated with thalamus and central nervous system
3) Confidence 0.71 Published 2000 Journal J. Comp. Neurol. Section Abstract Doc Link 11064370 Disease Relevance 0 Pain Relevance 0.25
Striatal tissues were dissected 12 hours after the last L-DOPA treatment and total RNA was extracted [27] to measure the levels of preproTRH mRNA with qPCR.
Transcription (levels) of preproTRH
4) Confidence 0.69 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2978093 Disease Relevance 0.09 Pain Relevance 0.20
The levels of preproTRH mRNA were significantly increased in the dopamine-depleted striatum of the rats that developed dyskinesia in response to the L-DOPA treatment (mixed design analysis of variance [ANOVA]; Treatment × Side interaction: F1,31?
Transcription (levels) of preproTRH in striatum associated with dopamine and dyskinesias
5) Confidence 0.69 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2978093 Disease Relevance 0.10 Pain Relevance 0.21
PreproTRH mRNA levels in the dopamine-depleted striatum of the L-DOPA-treated animals were positively correlated with the behavioral scores (Pearson's r ?
Transcription (levels) of PreproTRH in striatum associated with dopamine
6) Confidence 0.69 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2978093 Disease Relevance 0.14 Pain Relevance 0.17
Together with TRH-DE, the putative terminator of TRH actions that shows in various, but not all, brain areas, an overlapping mRNA distribution pattern with both receptors, the distribution of TRH-R2 mRNA seems to provide the anatomical basis for the described effects of TRH on higher cognitive functions as well as its effect on arousal, locomotor activity, and pain perception.
Transcription (distribution) of TRH in brain associated with pain, cognitive disorder and eae
7) Confidence 0.69 Published 2000 Journal J. Comp. Neurol. Section Abstract Doc Link 11064370 Disease Relevance 0.19 Pain Relevance 0.35
In contrast to the very restricted mRNA expression of TRH-R1 in the central nervous system, TRH-R2 mRNA was widely distributed with highest transcript levels throughout the thalamus, in the cerebral and cerebellar cortex, medial habenulae, medial geniculate nucleus, pontine nuclei, and throughout the reticular formation.
Transcription (distributed) of TRH in habenulae associated with thalamus and central nervous system
8) Confidence 0.69 Published 2000 Journal J. Comp. Neurol. Section Abstract Doc Link 11064370 Disease Relevance 0 Pain Relevance 0.25
Preprothyrotropin-releasing hormone (ppTRH) mRNA is highly expressed in the central gray.
Transcription (expressed) of ppTRH in central gray
9) Confidence 0.63 Published 1996 Journal Neuropeptides Section Abstract Doc Link 8819143 Disease Relevance 0.09 Pain Relevance 0.79
To determine the neural basis for these effects of TRH and thyroid hormones, we examined the effects of dopamine depletion and subsequent L-DOPA treatment on the striatal expression of preproTRH mRNA by quantitative PCR (qPCR) and proTRH peptide by immunohistochemistry and by radioimmunoassay (RIA) [10], [20], [21].
Transcription (expression) of preproTRH in thyroid associated with dopamine
10) Confidence 0.53 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2978093 Disease Relevance 1.01 Pain Relevance 0.15
Both preproTRH mRNA and TRH peptide levels were increased, and these increases were selective for the combination of 6-OHDA-induced dopamine depletion and L-DOPA treatment.
Transcription (levels) of preproTRH associated with dopamine
11) Confidence 0.53 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2978093 Disease Relevance 0.09 Pain Relevance 0.23
ProTRH mRNA levels increased at 1 h post-injection in total hypothalamus and hippocampus, while they decreased in the frontal cortex.
Transcription (levels) of ProTRH in hippocampus associated with urological neuroanatomy and hippocampus
12) Confidence 0.53 Published 2000 Journal Neurochem. Int. Section Abstract Doc Link 10871700 Disease Relevance 0.49 Pain Relevance 0.36
The present study examined changes in mRNA expression of various neuropeptides at several stages of amygdala kindled seizures. 35S-labelled oligonucleotide probes for mRNA of enkephalin (ENK), dynorphin (DYN) and thyrotropin releasing hormone (TRH) were hybridized to brain sections of rats sacrificed 24 h after a stage 1 or stage 5 seizure, or 2 weeks after a stage 5 seizure.
Transcription (expression) of TRH in stage 1 associated with convulsion, dynorphin, neuropeptide, enkephalin and amygdala
13) Confidence 0.51 Published 1992 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 1359374 Disease Relevance 0.47 Pain Relevance 0.79
In contrast to the very restricted mRNA expression of TRH-R1 in the central nervous system, TRH-R2 mRNA was widely distributed with highest transcript levels throughout the thalamus, in the cerebral and cerebellar cortex, medial habenulae, medial geniculate nucleus, pontine nuclei, and throughout the reticular formation.
Transcription (expression) of TRH in medial geniculate nucleus associated with thalamus and central nervous system
14) Confidence 0.24 Published 2000 Journal J. Comp. Neurol. Section Abstract Doc Link 11064370 Disease Relevance 0 Pain Relevance 0.25
In contrast to the very restricted mRNA expression of TRH-R1 in the central nervous system, TRH-R2 mRNA was widely distributed with highest transcript levels throughout the thalamus, in the cerebral and cerebellar cortex, medial habenulae, medial geniculate nucleus, pontine nuclei, and throughout the reticular formation.
Transcription (distributed) of TRH in medial geniculate nucleus associated with thalamus and central nervous system
15) Confidence 0.23 Published 2000 Journal J. Comp. Neurol. Section Abstract Doc Link 11064370 Disease Relevance 0 Pain Relevance 0.25
Just like the mRNA coding for the precursor of SP (preprotachykinin, PPT), levels of TRH mRNA are increased when serotonin synthesis is inhibited by para-chlorophenylalanine (pCPA) and decreased when serotonin reuptake is blocked by zimelidine.
Transcription (levels) of TRH associated with serotonin and substance p
16) Confidence 0.23 Published 1993 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 8389958 Disease Relevance 0 Pain Relevance 0.58
Levels of TRH mRNA are still decreased after 14 days of zimelidine treatment, a time when levels of PPT mRNA have returned to control values.
Transcription (Levels) of TRH
17) Confidence 0.23 Published 1993 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 8389958 Disease Relevance 0 Pain Relevance 0.58
Leptin plasma levels fall during starvation and this is the physiological stimulus for suppression of pro-TRH mRNA expression in the paraventricular nucleus within the hypothalamus, which in turn will result in decreased activity in the HPT axis in order to save energy (447).
Transcription (expression) of pro-TRH in nucleus associated with starvation
18) Confidence 0.22 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0.40 Pain Relevance 0
ProTRH mRNA levels increased at 1 h post-injection in total hypothalamus and hippocampus, while they decreased in the frontal cortex.
Transcription (levels) of ProTRH in hypothalamus associated with urological neuroanatomy and hippocampus
19) Confidence 0.18 Published 2000 Journal Neurochem. Int. Section Abstract Doc Link 10871700 Disease Relevance 0.49 Pain Relevance 0.36

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