INT79231

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Context Info
Confidence 0.67
First Reported 1998
Last Reported 2010
Negated 1
Speculated 2
Reported most in Abstract
Documents 18
Total Number 20
Disease Relevance 9.16
Pain Relevance 3.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (NFKB1) mitochondrion (NFKB1) cytoplasm (NFKB1)
cytosol (NFKB1) signal transduction (NFKB1) nucleolus (NFKB1)
Anatomy Link Frequency
stromal cells 4
ileum 2
nucleus 2
endothelial cell 2
fat 2
NFKB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 151 99.78 Very High Very High Very High
Chronic pancreatitis 7 99.70 Very High Very High Very High
Inflammation 218 99.56 Very High Very High Very High
Kinase C 8 99.28 Very High Very High Very High
Angina 13 98.70 Very High Very High Very High
Inflammatory mediators 12 98.32 Very High Very High Very High
endometriosis 2 96.94 Very High Very High Very High
metalloproteinase 7 94.32 High High
Pain 15 90.48 High High
Inflammatory response 33 87.76 High High
Disease Link Frequency Relevance Heat
Pancreatitis 7 99.70 Very High Very High Very High
INFLAMMATION 282 99.56 Very High Very High Very High
Cancer 76 99.24 Very High Very High Very High
Necrosis 24 98.88 Very High Very High Very High
Cv General 3 Under Development 13 98.70 Very High Very High Very High
Brain Injury 34 98.64 Very High Very High Very High
Adhesions 26 98.56 Very High Very High Very High
Fibrosis 4 98.32 Very High Very High Very High
Endometriosis 11 96.94 Very High Very High Very High
Stress 28 96.64 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Conversely, a high fat diet is capable of inducing the activation and expression of certain transcription factors like NF-kappa B and hence inflammation (Liao et al., 1993), which might lead to increased cellular stress.
Positive_regulation (inducing) of Gene_expression (expression) of NF-kappa B in fat associated with stress and inflammation
1) Confidence 0.67 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2917219 Disease Relevance 0.81 Pain Relevance 0.09
Since endometriosis is associated with aberrant concentrations of inflammatory mediators in the peritoneal fluid, we investigated whether hCG may affect cytokine-dependent activation of the key-regulatory transcription factor NF-kappaB and expression of two nuclear factor kappa B (NF-kappaB)-inducible genes, tumour necrosing factor (TNF-alpha) and interleukin (IL)-1beta, in stromal cells isolated from ectopic endometriotic tissues.
Positive_regulation (activation) of Gene_expression (expression) of NF-kappaB in stromal cells associated with endometriosis, inflammatory mediators, cancer and cytokine
2) Confidence 0.65 Published 2007 Journal Mol. Hum. Reprod. Section Abstract Doc Link 17525069 Disease Relevance 0.82 Pain Relevance 0.30
Expression of the NFkappaB-regulated genes increased after cardioplegia and reperfusion, but this was not influenced by ischemic preconditioning in stable patients.
Positive_regulation (increased) of Gene_expression (Expression) of NFkappaB-regulated
3) Confidence 0.60 Published 2008 Journal Eur J Cardiothorac Surg Section Body Doc Link 18842422 Disease Relevance 0.05 Pain Relevance 0
In order to examine the role of NFkappabeta in the pathophysiology of CFS, this study examines the production of NFkappabeta p50 in unstimulated, 10 ng/mL TNF-alpha (tumor necrosis factor alpha) and 50 ng/mL PMA (phorbolmyristate acetate) stimulated peripheral blood lymphocytes of 18 unmedicated patients with CFS and 18 age-sex matched controls.
Spec (examines) Positive_regulation (unstimulated) of Spec (examines) Gene_expression (production) of p50 in lymphocytes associated with necrosis and cancer
4) Confidence 0.49 Published 2007 Journal Neuro Endocrinol. Lett. Section Abstract Doc Link 17693979 Disease Relevance 0.83 Pain Relevance 0.14
Since endometriosis is associated with aberrant concentrations of inflammatory mediators in the peritoneal fluid, we investigated whether hCG may affect cytokine-dependent activation of the key-regulatory transcription factor NF-kappaB and expression of two nuclear factor kappa B (NF-kappaB)-inducible genes, tumour necrosing factor (TNF-alpha) and interleukin (IL)-1beta, in stromal cells isolated from ectopic endometriotic tissues.
Positive_regulation (activation) of Gene_expression (expression) of nuclear factor kappa B in stromal cells associated with endometriosis, inflammatory mediators, cancer and cytokine
5) Confidence 0.47 Published 2007 Journal Mol. Hum. Reprod. Section Abstract Doc Link 17525069 Disease Relevance 0.82 Pain Relevance 0.30
On the other hand, cotransfection of p50 shows a similar effect (Fig. 6).
Positive_regulation (cotransfection) of Gene_expression (cotransfection) of p50
6) Confidence 0.41 Published 2002 Journal BMC Mol Biol Section Body Doc Link PMC140029 Disease Relevance 0.14 Pain Relevance 0
This study aims to investigate the relationship of PARP-1 in circulating mononuclear cells (MNCs) and plasma TNF-alpha and IL-6 in UA patients and to elucidate the mechanism that PARP-1 promotes TNF-alpha and IL-6 expression via NF-kappaB pathway.
Positive_regulation (promotes) of Gene_expression (expression) of NF-kappaB in MNCs associated with angina
7) Confidence 0.40 Published 2008 Journal Arch. Med. Res. Section Abstract Doc Link 18996291 Disease Relevance 0.44 Pain Relevance 0.48
Effect of inflexinol on LPS-induced p50/p65
Positive_regulation (induced) of Gene_expression (/) of p50
8) Confidence 0.39 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC1874678 Disease Relevance 0.07 Pain Relevance 0.07
PTGES induction was blocked both in the presence of pharmacological NFkappaB inhibitors and following adenovirus-mediated overexpression of a dominant-negative NFkappaB pathway protein.
Positive_regulation (overexpression) of Gene_expression (overexpression) of NFkappaB
9) Confidence 0.38 Published 2008 Journal Biol. Reprod. Section Abstract Doc Link 17928629 Disease Relevance 0.12 Pain Relevance 0.24
The aim of this study was to investigate the effect of the non-steroidal anti-inflammatory agent sodium salicylate on TNF-alpha-induced activation of the transcription factor nuclear factor-kappaB (NF-kappaB) and upregulation of intercellular adhesion molecule-1 (ICAM-1), and TNF-alpha-stimulated cell migration and invasion through fibronectin.
Positive_regulation (activation) of Gene_expression (induced) of NF-kappaB associated with inflammation and adhesions
10) Confidence 0.37 Published 2006 Journal Melanoma Res. Section Abstract Doc Link 16432451 Disease Relevance 0.69 Pain Relevance 0.05
Expression of constitutively active PKCs induced an increase in NF-kappa B transcriptional activity and NAG-1 protein levels in LNCaP cells.
Positive_regulation (increase) of Gene_expression (levels) of NF-kappa B
11) Confidence 0.36 Published 2005 Journal J. Biol. Chem. Section Abstract Doc Link 15757899 Disease Relevance 0.43 Pain Relevance 0.26
Pretreatment with protein kinase C (PKC) inhibitor blocked the TPA-induced increase in NAG-1 protein levels and NF-kappa B binding/transcriptional activity, whereas an inhibition of p38, JNK, MEK activity had no effect on TPA-induced NAG-1 levels and NF-kappa B transcriptional activity.
Positive_regulation (increase) of Gene_expression (levels) of NF-kappa B associated with kinase c
12) Confidence 0.36 Published 2005 Journal J. Biol. Chem. Section Abstract Doc Link 15757899 Disease Relevance 0.45 Pain Relevance 0.25
B p50/p65 to the nucleus by promoting the phosphorylation of I?
Positive_regulation (promoting) of Gene_expression (/) of p50 in nucleus
13) Confidence 0.29 Published 2009 Journal Retrovirology Section Body Doc Link PMC2805609 Disease Relevance 0.64 Pain Relevance 0
Capsiate inhibited UVB-induced cyclooxygenase-2 (COX-2) expression, extracellular signal-related kinase 1/2 phosphorylation, nuclear translocation of NF-kappaB, and the expression of proinflammatory cytokines and potent angiogenic factors, including vascular endothelial cell growth factor and matrix metalloproteinase-2 (MMP-2) and MMP-9.
Positive_regulation (induced) of Gene_expression (expression) of NF-kappaB in endothelial cell associated with metalloproteinase and cytokine
14) Confidence 0.26 Published 2010 Journal Free Radic. Biol. Med. Section Abstract Doc Link 20123015 Disease Relevance 0.16 Pain Relevance 0.24
B p50 expression in ileum was not significantly
Neg (not) Positive_regulation (was) of Gene_expression (expression) of p50 in ileum
15) Confidence 0.10 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC2222592 Disease Relevance 0.43 Pain Relevance 0.07
In this p50/p65/I?
Positive_regulation (this) of Gene_expression (/) of p50
16) Confidence 0.10 Published 2007 Journal Immun Ageing Section Body Doc Link PMC1845171 Disease Relevance 0.11 Pain Relevance 0.13
Nuclear factor-kappaB (NF-kappaB) is a required transcription factor for Ang II-inducible IL-6 expression.
Positive_regulation (inducible) of Gene_expression (expression) of NF-kappaB
17) Confidence 0.10 Published 2007 Journal Immun Ageing Section Body Doc Link PMC1845171 Disease Relevance 0.23 Pain Relevance 0.11
This induction takes place in the absence of peroxisome proliferator-response elements (PPRE), but requires the presence of NF-kappaB and Sp1 elements in the IkappaB alpha promoter sequence as well as DRIP250 cofactors [59].
Positive_regulation (requires) of Gene_expression (presence) of NF-kappaB
18) Confidence 0.10 Published 2007 Journal Immun Ageing Section Body Doc Link PMC1845171 Disease Relevance 0.24 Pain Relevance 0.18
We conclude from these studies that indomethacin activates NFKB (possibly via TNF synthesis) in gastric microvascular endothelial cells, thereby enhancing surface expression of ICAM-1 which binds the CD18 on polymorphonuclear leukocytes (PMNs).
Spec (possibly) Positive_regulation (activates) of Gene_expression (synthesis) of NFKB in polymorphonuclear leukocytes
19) Confidence 0.09 Published 1998 Journal J. Clin. Gastroenterol. Section Abstract Doc Link 9872503 Disease Relevance 0.40 Pain Relevance 0.20
[Parenchymal regression in chronic pancreatitis spares islets reprogrammed for expression of NFkappaB and IAPs].
Positive_regulation (reprogrammed) of Gene_expression (expression) of NFkappaB associated with chronic pancreatitis
20) Confidence 0.06 Published 2006 Journal Verh Dtsch Ges Pathol Section Title Doc Link 17867593 Disease Relevance 1.27 Pain Relevance 0.54

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