INT79234

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Context Info
Confidence 0.67
First Reported 1998
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 15
Total Number 18
Disease Relevance 11.43
Pain Relevance 4.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CCL3) extracellular space (CCL3) extracellular region (CCL3)
intracellular (CCL3) cytoskeleton organization (CCL3) kinase activity (CCL3)
Anatomy Link Frequency
macrophage 4
plasma 3
lung 2
MC3T3-E1 1
microglial cells 1
CCL3 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 270 100.00 Very High Very High Very High
Inflammation 113 100.00 Very High Very High Very High
peptic ulcer disease 2 99.70 Very High Very High Very High
cytokine 124 98.78 Very High Very High Very High
rheumatoid arthritis 98 98.60 Very High Very High Very High
Neuritis 3 96.12 Very High Very High Very High
Sciatic nerve 1 93.48 High High
Multiple sclerosis 2 88.00 High High
Pain 4 83.36 Quite High
Inflammatory mediators 15 82.68 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 140 100.00 Very High Very High Very High
Disease 92 99.70 Very High Very High Very High
Ulcers 2 99.54 Very High Very High Very High
Gastritis 8 99.08 Very High Very High Very High
Infection 161 98.72 Very High Very High Very High
Immunization 1 98.68 Very High Very High Very High
Rheumatoid Arthritis 98 98.60 Very High Very High Very High
Bone Cancer 1 98.32 Very High Very High Very High
Drug Induced Neurotoxicity 2 97.94 Very High Very High Very High
Experimental Autoimmune Neuritis 2 96.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Significantly higher levels of MIP-1alpha and IL-8 were detected in patients with H. pylori infection than in those without infection.
Positive_regulation (levels) of MIP-1alpha associated with infection
1) Confidence 0.67 Published 1998 Journal J. Clin. Gastroenterol. Section Abstract Doc Link 9872512 Disease Relevance 1.14 Pain Relevance 0.23
The mRNAs for MIP-1alpha and MIP-1beta were found to be upregulated with peak values at day 13 post-immunization (p.i.), preceding maximum disease severity.
Positive_regulation (upregulated) of MIP-1alpha associated with immunization and disease
2) Confidence 0.67 Published 2000 Journal J. Neuroimmunol. Section Abstract Doc Link 11024541 Disease Relevance 0.76 Pain Relevance 0.59
Macrophage inflammatory protein 1alpha (MIP-1alpha) was elevated without change after switching to SRT.
Positive_regulation (elevated) of MIP-1alpha in Macrophage associated with inflammation
3) Confidence 0.67 Published 2008 Journal Calcif. Tissue Int. Section Abstract Doc Link 18553043 Disease Relevance 0.61 Pain Relevance 0.16
Paradoxically, constant inflammatory signals provided by the significant increase in several chemokines (CCL2, CCL3, CCL19, CXCL8, CXCL10, CXCL11) and pro-inflammatory cytokines (IL6, IL17, IL1A, IL1B, TNF) in the lung cells may have resulted in massive infiltration of leucocytes and excessive tissue damage.
Positive_regulation (increase) of CCL3 in lung associated with chemokine, inflammation and cytokine
4) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2948498 Disease Relevance 0.61 Pain Relevance 0.29
In H. pylori-positive patients, mucosal specimens from patients with peptic ulcer disease showed higher levels of MIP-1alpha and IL-8 than the specimens obtained from patients with erosive gastritis or those from endoscopically normal mucosa, and this was particularly pronounced in patients with duodenal ulcer.
Positive_regulation (levels) of MIP-1alpha associated with peptic ulcer disease, duodenal ulcer, gastritis and disease
5) Confidence 0.49 Published 1998 Journal J. Clin. Gastroenterol. Section Abstract Doc Link 9872512 Disease Relevance 1.21 Pain Relevance 0.28
RANKL mRNA and RANKL protein expressions increased in both ST2 cells and MC3T3-E1 cells in a MIP-1alpha concentration-dependent manner.
Positive_regulation (increased) of MIP-1alpha in MC3T3-E1
6) Confidence 0.49 Published 2007 Journal Mol. Cell. Biochem. Section Abstract Doc Link 17549607 Disease Relevance 0.31 Pain Relevance 0.11
CCR5 is most likely involved in the attraction and activation of these macrophages, since the CCR5 ligands RANTES and MIP-1alpha are concomitantly upregulated.


Positive_regulation (upregulated) of MIP-1alpha in macrophages
7) Confidence 0.45 Published 2000 Journal Surgery Section Body Doc Link 11056444 Disease Relevance 0 Pain Relevance 0
However, serum levels of IL-6, CCL2 monocyte chemoattractant protein-1 (MCP-1), CCL3 [macrophage inflammatory protein-1alpha (MIP-1alpha)] and CCL4 (MIP-1beta) were markedly elevated.
Positive_regulation (elevated) of CCL3 in macrophage associated with inflammation
8) Confidence 0.36 Published 2009 Journal International journal of laboratory hematology Section Abstract Doc Link 18177436 Disease Relevance 0.75 Pain Relevance 0.17
We identified higher plasma levels of IL1RA, IL2, IL6, CCL3, CCL4 and IL10 as markers of severity.
Positive_regulation (levels) of CCL3 in plasma
9) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2948498 Disease Relevance 1.02 Pain Relevance 0.20
The disease severity correlated with increased plasma levels of IL1RA, IL2, IL6, CCL3, CCL4 and IL10.
Positive_regulation (increased) of CCL3 in plasma associated with disease
10) Confidence 0.33 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2948498 Disease Relevance 0.59 Pain Relevance 0.07
Comparison of lung cytokines and chemokines at protein and gene levels showed comparable elevated levels of IL12B, CXCL8, IL1B, CCL3, IL1A and IL6 while IL17, TNF and IL10 were elevated only at the gene level.
Positive_regulation (elevated) of CCL3 in lung associated with chemokine and cytokine
11) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2948498 Disease Relevance 0.56 Pain Relevance 0.14
, and CCL3 increasing again after 6 weeks of SHIV-RT infection of the naïve animals (not statistically significant).
Positive_regulation (increasing) of CCL3 associated with infection
12) Confidence 0.25 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2787245 Disease Relevance 1.13 Pain Relevance 0.20
Representative CC chemokines are CCL2 (also called monocyte chemotactic protein, MCP-1), CCL3 and CCL4 (macrophage inflammatory protein MIP-1?
Positive_regulation (called) of CCL3 in macrophage associated with chemokine and inflammation
13) Confidence 0.25 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2798669 Disease Relevance 0.10 Pain Relevance 0.37
SF PMN from patients with RA exhibit a characteristic chemokine expression pattern resembling the upregulation of CCL3, CCL18, CXCL8 and CXCL10 mRNAs and the downregulation of CCL21 mRNA.
Positive_regulation (upregulation) of CCL3 associated with chemokine and rheumatoid arthritis
14) Confidence 0.21 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212580 Disease Relevance 0.78 Pain Relevance 0.47
Moreover, because PMN are recruited into SF, a characteristic chemokine expression profile is induced with highly upregulated mRNAs for CCL3, CCL18, CXCL8 and CXCL10 and downregulation of CCL21 mRNA.


Positive_regulation (upregulated) of CCL3 associated with chemokine
15) Confidence 0.21 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212580 Disease Relevance 0.53 Pain Relevance 0.44
By expanding our search for the expression of cytokines and chemokines that were potentially relevant to B. burgdorferi-induced neurotoxicity we found that in addition to IL-6, IL-8 and TNF, the four well known proinflammatory chemokines CCL2, CCL3, CCL4 and CCL5 were significantly upregulated in microglial cells co-cultured with B. burgdorferi.
Positive_regulation (upregulated) of CCL3 in microglial cells associated with chemokine, drug induced neurotoxicity and cytokine
16) Confidence 0.17 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2771360 Disease Relevance 0.90 Pain Relevance 0.42
RESULTS: Significantly increased levels of cytokines (IL-1alpha, IL-1beta, IL-6, IL-10, IL12p70) and chemokines (CCL1, CCL3, CCL4, CCL17, CCL22, CXCL8/IL-8) were observed in seminal plasmas from patients with CP/CPPS or BPH.
Positive_regulation (increased) of CCL3 in plasmas
17) Confidence 0.10 Published 2007 Journal Eur. Urol. Section Body Doc Link 16905241 Disease Relevance 0.38 Pain Relevance 0
Further, comparative analysis by semiquantitative RT-PCR analysis was performed for other CXC/CC chemokines (CXCL9, CXCL11, CCL3, CCL4, CCL5) and receptor (CCR5) which revealed their upregulation in the diseased state.
Positive_regulation (upregulation) of CCL3
18) Confidence 0.07 Published 2007 Journal Pancreatology Section Body Doc Link 17912012 Disease Relevance 0.06 Pain Relevance 0

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