INT7924

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Context Info
Confidence 0.40
First Reported 1989
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 25
Total Number 25
Disease Relevance 4.51
Pain Relevance 8.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Pigm)
Anatomy Link Frequency
hippocampus 4
liver 2
stage 5 2
nucleus accumbens 1
neurons 1
Pigm (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Hippocampus 42 100.00 Very High Very High Very High
Dynorphin 22 100.00 Very High Very High Very High
Spinal cord 2 100.00 Very High Very High Very High
antagonist 4 99.96 Very High Very High Very High
dexamethasone 10 99.88 Very High Very High Very High
Nucleus accumbens 3 99.68 Very High Very High Very High
alcohol 17 99.02 Very High Very High Very High
medulla 3 99.00 Very High Very High Very High
aspirin 6 97.36 Very High Very High Very High
Morphine 11 97.04 Very High Very High Very High
Disease Link Frequency Relevance Heat
Convulsion 29 100.00 Very High Very High Very High
Generalized Anxiety Disorder 3 100.00 Very High Very High Very High
Frailty 3 99.18 Very High Very High Very High
Shock 12 97.16 Very High Very High Very High
Dyskinesias 8 85.12 High High
Acute-phase Reaction 3 75.00 Quite High
Glioma 2 75.00 Quite High
Disease 5 60.68 Quite High
Neurodegenerative Disease 1 57.52 Quite High
Genetic Predisposition To Disease 1 50.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, at 8 h after the onset of the alcohol infusion, when BAC was falling toward baseline, PPENK mRNA was decreased in the nucleus accumbens of both P and NP rats and in the anterior striatum and amygdala of NP rats.
Negative_regulation (decreased) of PPENK mRNA in nucleus accumbens associated with nucleus accumbens, amygdala and alcohol
1) Confidence 0.40 Published 1998 Journal Brain Res. Section Abstract Doc Link 9630499 Disease Relevance 0.05 Pain Relevance 0.81
In the slow kindling model, the level of DYN mRNA in the hippocampus was reduced by 57%, whereas the level of striatal DYN mRNA was increased by 34% compared to sham-operated controls.
Negative_regulation (reduced) of DYN mRNA in hippocampus associated with hippocampus
2) Confidence 0.33 Published 1989 Journal Brain Res. Section Abstract Doc Link 2776033 Disease Relevance 0.19 Pain Relevance 0.34
Fast kindling induced a similar decrease in the DYN mRNA level in the hippocampus, but did not alter that in the striatum.
Negative_regulation (decrease) of DYN mRNA in hippocampus associated with hippocampus
3) Confidence 0.25 Published 1989 Journal Brain Res. Section Abstract Doc Link 2776033 Disease Relevance 0.17 Pain Relevance 0.37
II, a dramatic reduction in the DYN mRNA level was observed in the hippocampus 24 h after a single or repeated ECS.
Negative_regulation (reduction) of DYN mRNA in hippocampus associated with shock and hippocampus
4) Confidence 0.13 Published 1989 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 2770451 Disease Relevance 0.84 Pain Relevance 0.28
Unilateral denervation of the hamster adrenal results in a time-dependent ipsilateral decrease in EC peptide and PPenk mRNA levels.
Negative_regulation (decrease) of PPenk mRNA
5) Confidence 0.08 Published 1991 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 1653391 Disease Relevance 0 Pain Relevance 0.26
Thus, by day 8 postsurgery, PPenk mRNA levels have declined by an average of 80% while EC peptides are reduced by 68% when compared to the innervated contralateral adrenal.
Negative_regulation (declined) of PPenk mRNA
6) Confidence 0.06 Published 1991 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 1653391 Disease Relevance 0 Pain Relevance 0.26
Treatment with LY274614, a competitive NMDA-receptor antagonist, blocked MTZ-induced convulsions and the MTZ-induction of c-fos and PPenk mRNAs in the hippocampus, and PPenk mRNA in the adrenal.
Negative_regulation (blocked) of PPenk mRNA in hippocampus associated with convulsion, antagonist and hippocampus
7) Confidence 0.05 Published 1993 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 8255173 Disease Relevance 0.17 Pain Relevance 0.30
The elevations of both proENK and proDYN mRNA levels induced by KA were inhibited by pre-administration with phenidone, but not with esculetin and aspirin.
Negative_regulation (inhibited) of proDYN mRNA associated with aspirin
8) Confidence 0.03 Published 1998 Journal Brain Res. Section Abstract Doc Link 9519284 Disease Relevance 0.26 Pain Relevance 0.36
The elevations of both proENK and proDYN mRNA levels induced by KA were significantly inhibited by the preadministration with melatonin.
Negative_regulation (inhibited) of proDYN mRNA
9) Confidence 0.03 Published 2000 Journal Hippocampus Section Abstract Doc Link 10902893 Disease Relevance 0 Pain Relevance 0.08
Stimulation of the perforant path elicits a behavioral response, wet dog shakes (WDS), and reduction in hippocampal dynorphin A(1-8) immunoreactivity (DYN-IR) and prodynorphin mRNA (DYN mRNA) in rats.
Negative_regulation (reduction) of DYN mRNA associated with dynorphin
10) Confidence 0.02 Published 1991 Journal Brain Res. Section Abstract Doc Link 1685342 Disease Relevance 0 Pain Relevance 0.37
The elevations of both proENK and proDYN mRNA levels induced by KA were inhibited by pre-administration of CHX (15 mg/kg i.p.).
Negative_regulation (inhibited) of proDYN mRNA
11) Confidence 0.02 Published 1997 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9221929 Disease Relevance 0 Pain Relevance 0.08
The elevations of both proENK and proDYN mRNA levels induced by KA was effectively inhibited by pre-administration of L-ARG (400 mg/kg, i.p.), but was not affected by pre-treatment with L-NAME (200 mg/kg, i.p.).
Negative_regulation (inhibited) of proDYN mRNA
12) Confidence 0.02 Published 1998 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9602069 Disease Relevance 0 Pain Relevance 0.08
The blockade of KA-induced proENK and proDYN mRNA levels by the pre-treatment with L-ARG was well correlated with proto-oncoprotein levels, such as c-Fos, Fra-2, FosB, JunD, JunB, and c-Jun, as well as AP-1 and ENKCRE-2 DNA binding activities.
Negative_regulation (blockade) of proDYN mRNA
13) Confidence 0.02 Published 1998 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9602069 Disease Relevance 0 Pain Relevance 0.08
In contrast, DYN mRNA was decreased bilaterally in the dentate gyrus 24 h after a stage 5 seizure, but returned to control levels two weeks after a stage 5 seizure.
Negative_regulation (decreased) of DYN mRNA in stage 5 associated with convulsion and dynorphin
14) Confidence 0.02 Published 1992 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 1359374 Disease Relevance 0.77 Pain Relevance 0.75
In contrast, a decrease in DYN mRNA levels only was observed after treatment with ropinirole.
Negative_regulation (decrease) of DYN mRNA associated with dynorphin
15) Confidence 0.02 Published 2008 Journal Synapse Section Abstract Doc Link 18435422 Disease Relevance 0.49 Pain Relevance 0.49
In contrast, DYN mRNA was decreased bilaterally in the dentate gyrus 24 h after a stage 5 seizure, but returned to control levels two weeks after a stage 5 seizure.
Negative_regulation (decreased) of DYN mRNA in stage 5 associated with convulsion and dynorphin
16) Confidence 0.01 Published 1992 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 1359374 Disease Relevance 0.77 Pain Relevance 0.75
These simulations suggest that both receptor mRNA and free cytosolic receptor are maintained at very low levels during long-term MPL infusion, which is consistent with our measurements in the liver from these same animals (Ramakrishnan et al. 2002).
Negative_regulation (maintained) of mRNA in liver
17) Confidence 0.01 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733097 Disease Relevance 0 Pain Relevance 0.06
Dexamethasone also reduced forskolin-stimulated CAT mRNA levels in C6 cells stably transfected with proenkephalin/CAT chimeric genes in the presence or absence of proteins synthesis.
Negative_regulation (reduced) of mRNA associated with dexamethasone
18) Confidence 0.01 Published 1991 Journal Mol. Endocrinol. Section Abstract Doc Link 1658636 Disease Relevance 0.13 Pain Relevance 0.23
A low level of preproenkephalin A mRNA was seen in the adrenal medulla in animals injected with saline and 0.5 h after lipopolysaccharide administration.
Negative_regulation (level) of mRNA in adrenal medulla associated with medulla
19) Confidence 0.01 Published 1995 Journal Neuroimmunomodulation Section Abstract Doc Link 8521141 Disease Relevance 0 Pain Relevance 0.36
Unilateral adrenal denervation resulted in a rapid decrease in PPenk mRNA levels of 54% after 2 days, and by 11 days 90% of Penk mRNA had disappeared.
Negative_regulation (decrease) of PPenk mRNA
20) Confidence 0.01 Published 1991 Journal Mol. Pharmacol. Section Abstract Doc Link 1717819 Disease Relevance 0 Pain Relevance 0.20

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