INT79243

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Context Info
Confidence 0.57
First Reported 1999
Last Reported 2000
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 1.35
Pain Relevance 0.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (CTSB) mitochondrion (CTSB) extracellular space (CTSB)
extracellular region (CTSB) intracellular (CTSB) lysosome (CTSB)
Anatomy Link Frequency
neuronal 2
CTSB (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 5 99.52 Very High Very High Very High
Inflammation 3 92.56 High High
cytokine 1 91.64 High High
Inflammatory marker 1 80.16 Quite High
COX-2 inhibitor 1 74.24 Quite High
Neurotransmitter 2 60.88 Quite High
Glutamate receptor 1 53.40 Quite High
Disease Link Frequency Relevance Heat
Alzheimer's Dementia 6 99.72 Very High Very High Very High
Necrosis 1 98.24 Very High Very High Very High
Cancer 1 98.06 Very High Very High Very High
INFLAMMATION 6 91.24 High High
Disease 6 89.48 High High
Amyloid Plaque 1 81.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We show that the combination of tumor necrosis factor alpha and interferon gamma triggers the production of beta-amyloid peptides and inhibits the secretion of soluble APPs by human neuronal and extraneuronal cells.
Negative_regulation (inhibits) of Localization (secretion) of APPs in neuronal associated with necrosis, cancer and alzheimer's dementia
1) Confidence 0.57 Published 1999 Journal FASEB J. Section Abstract Doc Link 9872930 Disease Relevance 1.15 Pain Relevance 0.31
We previously showed that elevations in cAMP, perhaps generated in response to prostaglandins, can suppress APPs secretion.
Negative_regulation (suppress) of Localization (secretion) of APPs
2) Confidence 0.10 Published 2000 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 11193162 Disease Relevance 0.20 Pain Relevance 0.42

General Comments

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