INT79248

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Context Info
Confidence 0.44
First Reported 1998
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 13
Total Number 14
Disease Relevance 3.44
Pain Relevance 9.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Prkcg) plasma membrane (Prkcg) nucleus (Prkcg)
intracellular (Prkcg) response to stress (Prkcg) cytoplasm (Prkcg)
Anatomy Link Frequency
neuronal 2
spinal 2
secondary neurons 2
Prkcg (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Kinase C 421 100.00 Very High Very High Very High
nMDA receptor antagonist 58 99.92 Very High Very High Very High
IPN 9 99.08 Very High Very High Very High
Morphine 98 99.04 Very High Very High Very High
withdrawal 199 98.84 Very High Very High Very High
qutenza 86 98.80 Very High Very High Very High
adenocard 9 98.32 Very High Very High Very High
Pain 141 97.60 Very High Very High Very High
ischemia 13 97.48 Very High Very High Very High
Spinal cord 105 96.52 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cv General 4 Under Development 14 99.78 Very High Very High Very High
Inflammatory Pain 9 99.08 Very High Very High Very High
Nociception 57 98.84 Very High Very High Very High
Injury 29 98.10 Very High Very High Very High
Pain 128 97.60 Very High Very High Very High
Cv Unclassified Under Development 4 97.48 Very High Very High Very High
Bordatella Infection 1 94.00 High High
Hyperalgesia 124 93.32 High High
INFLAMMATION 26 90.12 High High
Arthritis 63 78.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, desensitization of protein kinase C (PKC) or inhibition of tyrosine kinase by herbimycin were ineffective.
Regulation (ineffective) of Negative_regulation (desensitization) of PKC associated with kinase c
1) Confidence 0.44 Published 1998 Journal Neuroendocrinology Section Abstract Doc Link 9873202 Disease Relevance 0.09 Pain Relevance 0.57
The present study was designed to characterize nociceptive response induced by 5-hydroxytryptamine (5-HT) and to investigate effects of inhibition of protein kinase C (PKC) in the periphery on noxious stimulus-evoked activity of the secondary neurons in the spinal cord.
Regulation (effects) of Negative_regulation (inhibition) of PKC in secondary neurons associated with nociception, kinase c and spinal cord
2) Confidence 0.43 Published 2006 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 16730785 Disease Relevance 0.25 Pain Relevance 0.51
l) a non-selective PKC inhibitor; AP5 (Sigma Chemical Co., St.
Regulation (selective) of Negative_regulation (inhibitor) of PKC associated with nmda receptor antagonist and kinase c
3) Confidence 0.43 Published 2006 Journal Mol Pain Section Body Doc Link PMC1482680 Disease Relevance 0.08 Pain Relevance 0.67
l), a non-selective PKC inhibitor [14,47]; chelytherine chloride (Sigma Chemical Co., St.
Regulation (selective) of Negative_regulation (inhibitor) of PKC associated with kinase c
4) Confidence 0.43 Published 2006 Journal Mol Pain Section Body Doc Link PMC1482680 Disease Relevance 0.12 Pain Relevance 0.70
Surprisingly, spinal blockade of PKC had no effect on the decreased mechanical withdrawal threshold induced by repeated intramuscular acid injections suggesting PKC activation in the spinal cord does not maintain the hyperalgesia once developed.
Neg (no) Regulation (effect) of Negative_regulation (blockade) of PKC in spinal associated with hyperalgesia, kinase c, withdrawal and spinal cord
5) Confidence 0.43 Published 2006 Journal Mol Pain Section Body Doc Link PMC1482680 Disease Relevance 0.37 Pain Relevance 1.44
The ability of the PKC inhibitors GF109023X (0.5 nmol/10 ?
Regulation (ability) of Negative_regulation (inhibitors) of PKC associated with kinase c
6) Confidence 0.43 Published 2006 Journal Mol Pain Section Body Doc Link PMC1482680 Disease Relevance 0.07 Pain Relevance 0.73
Ipsilateral, but not contralateral, calphostin C, a PKC inhibitor, blocked GAL-induced potentiation of CAP-evoked inflammatory pain in a dose-dependent fashion.
Regulation (contralateral) of Negative_regulation (inhibitor) of PKC associated with kinase c, qutenza and ipn
7) Confidence 0.43 Published 2005 Journal Brain Res. Section Abstract Doc Link 16125151 Disease Relevance 0.71 Pain Relevance 1.21
Moreover, whether the decrease in cerebral infarct volume is due to PKC inhibition in the neuronal tissue or an effect of the attenuation of the ETB receptor upregulation in the arteries remains to be investigated.


Spec (whether) Regulation (due) of Negative_regulation (inhibition) of PKC in neuronal associated with kinase c and cv general 4 under development
8) Confidence 0.40 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1770924 Disease Relevance 0.72 Pain Relevance 0.46
Although non-specific effects of these PKA and PKC inhibitors cannot be completely ruled out, these data indicate a likely upregulated PKC and PKA activity, which is at least partially responsible for the enhanced glutamate synaptic transmission in NRM secondary cells from morphine-tolerant rats.


Regulation (effects) of Negative_regulation (inhibitors) of PKC associated with raphe magnus, glutamate, kinase c and morphine
9) Confidence 0.39 Published 2005 Journal Mol Pain Section Body Doc Link PMC1074357 Disease Relevance 0.19 Pain Relevance 1.96
Cardiac functional resistance to ischemia-reperfusion (25/40 min) injury was examined 30 min and 1, 4, and 24 h after NE treatment with the Langendorff technique, and effects of alpha1-adrenoceptor antagonism and PKC inhibition on the protection were determined.
Regulation (effects) of Negative_regulation (inhibition) of PKC associated with kinase c, ischemia and injury
10) Confidence 0.37 Published 1999 Journal Am. J. Physiol. Section Abstract Doc Link 10233047 Disease Relevance 0.28 Pain Relevance 0.30
A membrane-permeable selective PKC inhibitor (GF109203X [53]) affected neither normal synaptic transmission (Figure 7A,C) nor synaptic plasticity (Figure 7B,D).
Neg (nor) Regulation (affected) of Negative_regulation (inhibitor) of PKC
11) Confidence 0.34 Published 2008 Journal Mol Pain Section Body Doc Link PMC2490682 Disease Relevance 0.52 Pain Relevance 0.52
M BIM (bisindolylmaleimide), a specific PKC inhibitor, 25 ?
Regulation (specific) of Negative_regulation (inhibitor) of PKC associated with kinase c
12) Confidence 0.18 Published 2010 Journal Mol Pain Section Body Doc Link PMC2936373 Disease Relevance 0 Pain Relevance 0.36
In addition, MAPKs were also involved in the survival signalling mechanism triggered by BDNF (Fig. 6).Fig. 5Effect of PKC and MAPK inhibition on GSK3 phosphorylation levels under conditions of PI3K inhibition.
Regulation (5Effect) of Negative_regulation (inhibition) of PKC
13) Confidence 0.15 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2858808 Disease Relevance 0.06 Pain Relevance 0
To analyse the role of PKC activation in ET-1-mediated potentiation of TRPV1, we tested the effect of the PKC inhibitor BIM X on the potentiation of capsaicin-induced TRPV1 currents in response to ET-1.
Regulation (effect) of Negative_regulation (inhibitor) of PKC associated with qutenza
14) Confidence 0.11 Published 2007 Journal Mol Pain Section Body Doc Link PMC2206006 Disease Relevance 0 Pain Relevance 0.38

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