INT79250

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Context Info
Confidence 0.54
First Reported 1998
Last Reported 2003
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.06
Pain Relevance 1.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Gnrh1) extracellular region (Gnrh1) molecular_function (Gnrh1)
Anatomy Link Frequency
medial 2
pituitary 2
Gnrh1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Opioid 4 99.16 Very High Very High Very High
opiate 10 98.14 Very High Very High Very High
noradrenaline 3 93.76 High High
agonist 4 88.32 High High
Dynorphin 2 86.76 High High
Kinase C 2 83.92 Quite High
Morphine 2 80.80 Quite High
Neuropeptide 3 80.12 Quite High
narcan 4 78.24 Quite High
antagonist 4 75.64 Quite High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 7 99.90 Very High Very High Very High
Bordatella Infection 2 99.08 Very High Very High Very High
Stress 6 94.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We conclude that an opiate delta receptor subtype is endogenously activated in the pituitary of castrated male rats to prevent masking of GnRH binding.
Negative_regulation (prevent) of GnRH Binding (binding) of in pituitary associated with opiate
1) Confidence 0.54 Published 1998 Journal Neuroendocrinology Section Abstract Doc Link 9873202 Disease Relevance 0 Pain Relevance 0.86
Stimulation of CRH neurones in the paraventricular nucleus also activates gamma-aminobenzoic acid and opioid neurones in the medial preoptic area and reduces GnRH cell recruitment, thereby decreasing GnRH pulse frequency.
Negative_regulation (reduces) of GnRH Binding (recruitment) of in medial associated with urological neuroanatomy and opioid
2) Confidence 0.43 Published 2003 Journal Reproduction Section Abstract Doc Link 12578529 Disease Relevance 0.96 Pain Relevance 0.54
Spontaneous unmasking of GnRH binding was found reversed by pertussis toxin (PTX), an inhibitor of alphai and alphao subunits of heterotrimeric G proteins, and by U73122, a phospholipase C (PLC) inhibitor.
Negative_regulation (unmasking) of GnRH Binding (binding) of associated with bordatella infection
3) Confidence 0.40 Published 1998 Journal Neuroendocrinology Section Abstract Doc Link 9873202 Disease Relevance 0.10 Pain Relevance 0.34

General Comments

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