INT79252

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Context Info
Confidence 0.67
First Reported 1998
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 4
Disease Relevance 0.28
Pain Relevance 1.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (BHLHE23) DNA binding (BHLHE23)
BHLHE23 (Homo sapiens)
Pain Link Frequency Relevance Heat
Gabapentin 6 97.76 Very High Very High Very High
cytokine 6 97.52 Very High Very High Very High
Pain 1 96.96 Very High Very High Very High
agonist 3 96.84 Very High Very High Very High
Nicotine 2 94.96 High High
adenocard 12 90.12 High High
Inflammation 2 85.68 High High
antagonist 1 83.08 Quite High
Calcium channel 8 82.96 Quite High
cINOD 1 68.72 Quite High
Disease Link Frequency Relevance Heat
Disease 1 97.44 Very High Very High Very High
Pain 1 96.96 Very High Very High Very High
INFLAMMATION 3 85.68 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Compound 2 (SIB-1663), which selectively activated human recombinant alpha 2 beta 4 and alpha 4 beta 4 nAChRs, was shown to be active in animal models of Parkinson's disease and pain.
Positive_regulation (activated) of beta 4 associated with pain and disease
1) Confidence 0.67 Published 1998 Journal Bioorg. Med. Chem. Lett. Section Abstract Doc Link 9873508 Disease Relevance 0.19 Pain Relevance 0.23
This R282A mutant alpha2delta-2 shows reduced functionality in terms of enhancement of CaV2.1/beta4 calcium currents, suggesting that the integrity of the gabapentin binding site may be important for normal functioning of alpha2delta-2.
Positive_regulation (enhancement) of beta4 associated with gabapentin
2) Confidence 0.49 Published 2006 Journal J. Neurosci. Section Abstract Doc Link 16928863 Disease Relevance 0 Pain Relevance 0.35
Cholesterol depletion of intact cells disrupted their lipid rafts and enhanced CaV2.1/alpha2delta-2/beta4 currents.
Positive_regulation (enhanced) of beta4
3) Confidence 0.21 Published 2006 Journal J. Neurosci. Section Abstract Doc Link 16928863 Disease Relevance 0 Pain Relevance 0.30
HMVEC expressed a higher level of G protein beta1 isoform than beta4 isoform.
Positive_regulation (level) of beta4
4) Confidence 0.18 Published 2003 Journal J. Immunol. Section Abstract Doc Link 14530318 Disease Relevance 0.09 Pain Relevance 0.70

General Comments

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