INT79259

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Context Info
Confidence 0.40
First Reported 1998
Last Reported 2010
Negated 2
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 2.94
Pain Relevance 0.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Itgal)
Anatomy Link Frequency
spinal 1
lung 1
T cells 1
Itgal (Mus musculus)
Pain Link Frequency Relevance Heat
glial activation 3 95.20 Very High Very High Very High
metalloproteinase 10 82.04 Quite High
cytokine 43 75.08 Quite High
Inflammatory mediators 10 68.24 Quite High
Multiple sclerosis 18 65.20 Quite High
anesthesia 3 50.00 Quite Low
Inflammation 47 48.00 Quite Low
chemokine 20 36.20 Quite Low
Inflammatory stimuli 1 15.08 Low Low
ischemia 35 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypothermia 55 99.04 Very High Very High Very High
Disease 14 96.08 Very High Very High Very High
Respiratory Syncytial Virus 62 95.96 Very High Very High Very High
Infection 50 93.48 High High
Multiple Sclerosis 50 92.16 High High
Apoptosis 54 86.00 High High
Stroke 81 74.60 Quite High
INFLAMMATION 79 67.84 Quite High
Stress 6 45.60 Quite Low
Injury 15 34.16 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Low-frequency activity and LFa/HFa ratio were unchanged in the spinal anesthesia group and were significantly decreased in the general anesthesia group.
Neg (unchanged) Regulation (unchanged) of LFa in spinal
1) Confidence 0.40 Published 1998 Journal J Clin Anesth Section Body Doc Link 9873967 Disease Relevance 0 Pain Relevance 0
The beneficial effect of CpdA required expression of the GR in T cells and was achieved by down regulating LFA-1 and CD44 on peripheral Th cells and by repressing IL-17 production.


Regulation (regulating) of LFA-1 in T cells
2) Confidence 0.21 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2781169 Disease Relevance 0.67 Pain Relevance 0.10
Hypothermia (27°C) delays upregulation of Mac-1 and CD11c, but has no effect on LFA-1 [174,176].
Neg (no) Regulation (effect) of LFA-1 associated with hypothermia
3) Confidence 0.17 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2988764 Disease Relevance 1.06 Pain Relevance 0.09
CD11c+, but not CD11c-, CD8+ T cells showed signs of recent activation, including up-regulation of CD11a and expression of CD11b and CD69 and were recruited preferentially to the lung.
Regulation (regulation) of CD11a in lung
4) Confidence 0.15 Published 2005 Journal Respir Res Section Abstract Doc Link PMC1184101 Disease Relevance 1.21 Pain Relevance 0.04

General Comments

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