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Context Info
Confidence 0.37
First Reported 1998
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 2.11
Pain Relevance 0.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Itgal)
Anatomy Link Frequency
spinal 1
lymphocyte 1
apoptotic cells 1
Itgal (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 12 92.28 High High
Multiple sclerosis 34 85.96 High High
Inflammation 20 85.12 High High
cytokine 14 84.64 Quite High
Spinal cord 4 72.88 Quite High
anesthesia 2 50.00 Quite Low
cINOD 4 26.16 Quite Low
rheumatoid arthritis 8 20.00 Low Low
dexamethasone 44 5.00 Very Low Very Low Very Low
Inflammatory mediators 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Repression 2 100.00 Very High Very High Very High
Apoptosis 74 98.86 Very High Very High Very High
Death 26 98.10 Very High Very High Very High
Multiple Sclerosis 100 94.92 High High
Central Nervous System Disease 12 92.28 High High
INFLAMMATION 30 85.12 High High
Adhesions 8 80.84 Quite High
Disease 22 76.92 Quite High
Immunization 4 63.76 Quite High
Rheumatoid Arthritis 8 20.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Low-frequency activity and LFa/HFa ratio were unchanged in the spinal anesthesia group and were significantly decreased in the general anesthesia group.
Negative_regulation (decreased) of LFa in spinal
1) Confidence 0.37 Published 1998 Journal J Clin Anesth Section Body Doc Link 9873967 Disease Relevance 0 Pain Relevance 0
In particular lymphocyte death, a bona fide example of GR transactivation, is not induced at these CpdA concentrations while repression of IL-17, LFA-1 and CD-44 efficiently occurs.
Negative_regulation (repression) of LFA-1 in lymphocyte associated with repression and death
2) Confidence 0.14 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2781169 Disease Relevance 1.22 Pain Relevance 0.16
While the percentage of apoptotic cells was again unaltered, surface expression levels of LFA-1 and CD44 were reduced on Th cells from CpdA treated mice in a dose-dependent manner (Fig. 6B).
Negative_regulation (reduced) of LFA-1 in apoptotic cells associated with apoptosis
3) Confidence 0.06 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2781169 Disease Relevance 0.89 Pain Relevance 0.17

General Comments

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