INT79261

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Context Info
Confidence 0.36
First Reported 1998
Last Reported 2010
Negated 3
Speculated 0
Reported most in Body
Documents 24
Total Number 24
Disease Relevance 7.49
Pain Relevance 2.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (COL1A1) extracellular region (COL1A1) cytoplasm (COL1A1)
Anatomy Link Frequency
tendons 4
chondrocyte 2
macrophage 2
cartilage 2
fibroblasts 2
COL1A1 (Homo sapiens)
Pain Link Frequency Relevance Heat
reflex sympathetic dystrophy 30 100.00 Very High Very High Very High
Osteoarthritis 344 99.16 Very High Very High Very High
metalloproteinase 17 99.16 Very High Very High Very High
COX2 3 98.84 Very High Very High Very High
Pain 46 97.24 Very High Very High Very High
cytokine 82 84.80 Quite High
fibrosis 71 75.00 Quite High
visual analogue scale 5 71.84 Quite High
chemokine 21 61.76 Quite High
Endocannabinoid 24 59.00 Quite High
Disease Link Frequency Relevance Heat
Complex Regional Pain Syndromes 40 100.00 Very High Very High Very High
Osteoarthritis 340 99.16 Very High Very High Very High
Apoptosis 191 98.72 Very High Very High Very High
Hepatocellular Cancer 39 98.40 Very High Very High Very High
Primary Sclerosing Cholangitis 57 95.68 Very High Very High Very High
Rupture 5 94.16 High High
Cleidocranial Dysplasia 4 93.64 High High
Tendinopathy 8 92.40 High High
Knee Osteoarthritis 36 88.72 High High
Pain 34 87.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CRPS type I according to Veldman is diagnosed when four of the following five symptoms are present and occur or increase with activity:
Positive_regulation (according) of Gene_expression (diagnosed) of CRPS type I associated with reflex sympathetic dystrophy
1) Confidence 0.36 Published 2010 Journal The Open Orthopaedics Journal Section Body Doc Link PMC2835870 Disease Relevance 0.69 Pain Relevance 0.65
In the present article we report that physiological tonicity (380 mOsm) during isolation and monolayer expansion can suppress chondrocyte dedifferentiation and that expression of the extracelluar matrix components collagen type I and collagen type II as well as aggrecan is NFAT5 dependent.
Positive_regulation (dependent) of Gene_expression (expression) of collagen type I in chondrocyte
2) Confidence 0.35 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911888 Disease Relevance 0.47 Pain Relevance 0.15
To demonstrate that the hypertonicity-induced chondrogenic marker expression was indeed mediated by NFAT5, we used RNAi to confirm that knockdown of NFAT5 significantly inhibited hypertonic induction of its own transcription as discussed before, significantly suppressed the tonicity-mediated induction of known NFAT5 targets, and, most importantly, significantly eliminated the hypertonicity-mediated mRNA expression of chondrogenic marker genes (COL2, AGC1, SOX9 and COL1).


Positive_regulation (mediated) of Gene_expression (expression) of COL1
3) Confidence 0.35 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911888 Disease Relevance 0.06 Pain Relevance 0.03
Interestingly, expression of COL1 increased after NFAT5 RNAi in OA HACs to ~300% of control levels (Figure 5b).


Positive_regulation (increased) of Gene_expression (expression) of COL1 associated with osteoarthritis
4) Confidence 0.33 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911888 Disease Relevance 0.29 Pain Relevance 0.14
RESULTS: Painful and ruptured tendons showed a significant decrease (median 2-fold) in the expression of versican mRNA, in contrast to an increased expression (median 8-fold) of type I collagen alpha1 mRNA in painful tendons.
Positive_regulation (increased) of Gene_expression (expression) of type I collagen alpha1 mRNA in tendons
5) Confidence 0.27 Published 2004 Journal Rheumatology (Oxford) Section Body Doc Link 15138331 Disease Relevance 0.08 Pain Relevance 0
Gene expression of collagen type-II, collagen type-I, aggrecan, MMP-13, IL-6, Il-1?
Positive_regulation (Gene) of Gene_expression (expression) of collagen type-I
6) Confidence 0.26 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC2921357 Disease Relevance 0.11 Pain Relevance 0
Furthermore, blending PLLA nanofibers with collagen had a positive effect on the gene expression of collagen I, III, X and decorin.
Positive_regulation (effect) of Gene_expression (expression) of collagen I
7) Confidence 0.20 Published 2010 Journal Biomed Eng Online Section Abstract Doc Link PMC2837661 Disease Relevance 0 Pain Relevance 0
TGFbeta1 treatment upregulated the expression of alphaSMA, collagen type I (Col I), fibronectin and TGFbeta1.
Positive_regulation (upregulated) of Gene_expression (expression) of collagen type I
8) Confidence 0.19 Published 2005 Journal Lab. Invest. Section Abstract Doc Link 16127427 Disease Relevance 1.04 Pain Relevance 0.12
Levels of serum alkaline phosphatase and urinary collagen type I N-telopeptide were elevated at baseline and decreased continuously during the first 3 yr of therapy.
Positive_regulation (elevated) of Gene_expression (Levels) of collagen type I N-telopeptide
9) Confidence 0.17 Published 2003 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 14557424 Disease Relevance 0.48 Pain Relevance 0.08
RESULTS: TGF-beta1 significantly stimulated alpha-SMA, collagen I and fibronectin production in peritoneal fibroblasts.
Positive_regulation (stimulated) of Gene_expression (production) of collagen I in fibroblasts
10) Confidence 0.16 Published 2010 Journal Med. Sci. Monit. Section Body Doc Link 20671605 Disease Relevance 0.08 Pain Relevance 0
Cells transformed with the COL1A1-PDGFB gene as well as cell cultures derived from patients with DFSP are inhibited by the tyrosine kinase inhibitor imatinib mesylate (Glivec or STI-571; Novartis, Basel, Switzerland) (Greco 2001, Sjoblom 2001).
Positive_regulation (transformed) of Gene_expression (transformed) of COL1A1-PDGFB
11) Confidence 0.14 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721290 Disease Relevance 0.22 Pain Relevance 0
There is increased expression of the COL1A1 gene, which encodes for the alpha1 chain of type I collagen, in the painful Achilles tendon.
Positive_regulation (increased) of Gene_expression (expression) of COL1A1 in tendon associated with pain
12) Confidence 0.12 Published 2009 Journal J Sci Med Sport Section Abstract Doc Link 18353721 Disease Relevance 0.60 Pain Relevance 0.10
This was demonstrated by an elevated alkaline phosphatase activity and osteocalcin release in response to stimulation with 1,25(OH)2D3, and an enhanced production of collagen type I (Table 1).
Positive_regulation (enhanced) of Gene_expression (production) of collagen type I
13) Confidence 0.10 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1794527 Disease Relevance 0.47 Pain Relevance 0.23
M), resulting in the strongly increased expression of pro-collagen type I, which was prevented by pre-treatment of cells with either vitamin E or the synthetic antioxidant diphenyl-phenylendiamine.
Positive_regulation (increased) of Gene_expression (expression) of pro-collagen type I
14) Confidence 0.08 Published 2008 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2584013 Disease Relevance 0.42 Pain Relevance 0
Other signalling pathways and elements have been proposed to mediate ROS-dependent collagen type I expression, including up-regulation of cyclooxygenase 2 [311] or the redox sensitive transcription factor Sp-1 [304,314], but it should be noted that again the H2O2-dependent involvement of the same C/EBP?
Positive_regulation (mediate) of Gene_expression (expression) of collagen type I associated with cox2
15) Confidence 0.08 Published 2008 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2584013 Disease Relevance 0.11 Pain Relevance 0.09
The activation of NOX and intracellular generation of ROS have been involved in the up-regulation of collagen type I expression in HSC/MFs after engulfment by apoptotic bodies from dead hepatocytes [97], a finding similar to an earlier report showing that macrophage engulfment of apoptotic bodies resulted in increased transcription of TGF?
Positive_regulation (regulation) of Gene_expression (expression) of collagen type I in macrophage associated with apoptosis
16) Confidence 0.08 Published 2008 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2584013 Disease Relevance 0.39 Pain Relevance 0.06
This was demonstrated by an elevated alkaline phosphatase activity and osteocalcin release in response to stimulation with 1,25(OH)2D3, and an enhanced production of collagen type I (Table 1).
Positive_regulation (enhanced) of Gene_expression (production) of collagen type I
17) Confidence 0.07 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1794527 Disease Relevance 0.47 Pain Relevance 0.23
It increases the synthesis of MMPs and plasminogen activator, essential to convert the pro-MMPs in MMPs, and regulate the organization of ECM by enhancing the synthesis of minor collagens, normally not present in cartilage, such as collagen types I and III, and decreasing the production of proteoglycans and collagen types II and IX, which represent the optimal scaffolding of cartilage [3].
Positive_regulation (enhancing) of Gene_expression (synthesis) of collagen types I and III in cartilage associated with metalloproteinase
18) Confidence 0.06 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2268688 Disease Relevance 0.31 Pain Relevance 0.35
Blockade of the CB2-receptor by AM630 did also not change collagen 1 and fibronectin production (Figure 4).
Neg (not) Positive_regulation (change) of Gene_expression (production) of collagen 1
19) Confidence 0.05 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2253501 Disease Relevance 0.17 Pain Relevance 0.20
In addition, the gene expressions in cHCC of SOCS3 and collagen-I were elevated (although not significantly) and inhibited, respectively, as it was also detected in human HCC [19].
Positive_regulation (elevated) of Gene_expression (expressions) of collagen-I associated with hepatocellular cancer
20) Confidence 0.05 Published 2004 Journal Comp Hepatol Section Body Doc Link PMC535891 Disease Relevance 0.59 Pain Relevance 0

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