INT79270

Context Info Confidence 0.77 First Reported 1998 Last Reported 2010 Negated 5 Speculated 5 Reported most in Body Documents 113 Total Number 119 Disease Relevance 63.52 Pain Relevance 3.38

cell proliferation (MKI67) nucleolus (MKI67) nucleus (MKI67) intracellular (MKI67) cell cycle (MKI67) DNA metabolic process (MKI67)

Anatomy Link Frequency T cells 6 epithelial cells 4 duct 3 B-cell 3 stroma 1 MKI67 (Homo sapiens)

Pain Link Frequency Relevance Heat fibrosis 38 99.44 Dismenorea 8 98.80 Leflunomide 378 98.24 metalloproteinase 8 96.00 endometriosis 144 91.16 Chronic pancreatitis 13 89.12 alcohol 14 86.36 cva 17 83.12 Spinal cord 87 82.04 Inflammation 78 73.76

Disease Link Frequency Relevance Heat Cancer 2789 99.98 Stomach Cancer 330 99.96 Microsatellite Instability 1 99.92 Aneuploidy 2 99.68 Hyperplasia 539 99.64 Breast Cancer 964 99.48 Immunotherapy Of Cancer 49 99.48 Apoptosis 911 99.44 Fibrosis 38 99.44 Carcinoma 126 99.36

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We therefore do not believe that HRT status had any significant impact on our results, namely a lack of correlation between mammographic density and Ki-67 expression.

Gene_expression (expression) of Ki-67

1) Confidence 0.77 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC1929099 Disease Relevance 0.48 Pain Relevance 0

Median level of Ki-67 expression was 1.9% (range 0% to 33%).

Gene_expression (expression) of Ki-67

2) Confidence 0.77 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC1929099 Disease Relevance 0.07 Pain Relevance 0

We have previously shown that Ki-67 expression in benign epithelial cells is positively correlated with epithelial cell number and cytomorphologic abnormality in women at increased risk for breast cancer [6].

Gene_expression (expression) of Ki-67 in epithelial cell associated with breast cancer

3) Confidence 0.77 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC1929099 Disease Relevance 0.58 Pain Relevance 0

The techniques of immediate per-operative in vitro labelling with bromodeoxyuridine (BrdU) and conventional immunohistochemistry for Ki-67 antigen expression were used to identify proliferating cells.

Gene_expression (expression) of Ki-67

4) Confidence 0.75 Published 1998 Journal J. Pathol. Section Abstract Doc Link 9875147 Disease Relevance 0.36 Pain Relevance 0.25

Immunohistochemistry showed expression of p53 oncoprotein and Ki-67 antigen in the carcinoma cells.

Gene_expression (expression) of Ki-67 associated with carcinoma

5) Confidence 0.75 Published 2001 Journal Pathol. Int. Section Abstract Doc Link 11350616 Disease Relevance 1.32 Pain Relevance 0.35

Ki-67 expression is currently being used in phase II breast cancer chemoprevention trials.

Gene_expression (expression) of Ki-67 associated with breast cancer

6) Confidence 0.68 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC1929099 Disease Relevance 0.71 Pain Relevance 0

In a recently reported study, Ki-67 (MIB-1) expression was assessed in areas of low, medium, and high mammographic density in benign breast tissue obtained from reduction mammoplasties.

Gene_expression (expression) of Ki-67

7) Confidence 0.68 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC1929099 Disease Relevance 0.50 Pain Relevance 0.04

Ki-67 expression in benign breast cells obtained from RPFNA is also a reversible, a potential risk and a possible surrogate response biomarker.

Gene_expression (expression) of Ki-67

8) Confidence 0.68 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC1929099 Disease Relevance 0.40 Pain Relevance 0

In a cohort of 147 high risk women, we previously showed that cytomorphologic atypia in benign breast cells obtained by RPFNA is associated with increased Ki-67 expression [6].

Gene_expression (expression) of Ki-67

9) Confidence 0.68 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC1929099 Disease Relevance 0.39 Pain Relevance 0

Contrary to what might be expected, Ki-67 expression in epithelial cells was less in the areas of medium and high density as compared with the areas of low density [32].

Gene_expression (expression) of Ki-67 in epithelial cells

10) Confidence 0.68 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC1929099 Disease Relevance 0.43 Pain Relevance 0.03

Ki-67 expression was greater in specimens exhibiting cytomorphologic atypia (P = 0.01) and greater cellularity (P = 0.001; Table 2).

Gene_expression (expression) of Ki-67

11) Confidence 0.68 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC1929099 Disease Relevance 0 Pain Relevance 0

Median Ki-67 expression was 2.8% in women with RPFNA atypia as compared with 1.1% in women without atypia.

Gene_expression (expression) of Ki-67

12) Confidence 0.68 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC1929099 Disease Relevance 0.34 Pain Relevance 0

There was no difference in Ki-67 expression between specimens from postmenopausal women receiving HRT and specimens from those who were not on HRT, but only 21% of women on HRT were on estrogen plus a progestin.

Gene_expression (expression) of Ki-67

13) Confidence 0.68 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC1929099 Disease Relevance 0.05 Pain Relevance 0

Ki-67 expression

Gene_expression (expression) of Ki-67

14) Confidence 0.68 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC1929099 Disease Relevance 0.07 Pain Relevance 0

After the antigen retrieval in a hot water bath, the prediluted monoclonal anti-Ki67 antibody (Biogenex, San Ramon, USA) was incubated for 30 min; antibody demonstration was performed with the commercially available anti-mouse IgG detection kit (EnVision, DakoCytomation).

Gene_expression (antibody) of Ki67

15) Confidence 0.65 Published 2006 Journal Virchows Arch Section Body Doc Link PMC1888720 Disease Relevance 0.73 Pain Relevance 0

Our findings indicate that mammographic density, cytomorphology, and Ki-67 expression are independent variables, and may be complementary when used as risk predictors or response biomarkers in breast cancer chemoprevention trials.

Gene_expression (expression) of Ki-67 associated with breast cancer

16) Confidence 0.60 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC1929099 Disease Relevance 0.69 Pain Relevance 0

Given the lack of correlation of mammographic breast density with either cytomorphology or Ki-67 expression in RPFNA specimens, mammographic density and Ki-67 expression should be considered as potentially complementary response biomarkers in breast cancer chemoprevention trials.

Gene_expression (expression) of Ki-67 associated with breast cancer

17) Confidence 0.60 Published 2007 Journal Breast Cancer Res Section Abstract Doc Link PMC1929099 Disease Relevance 0.24 Pain Relevance 0

Furthermore, our results continue to show that Ki-67 expression is associated with the risk biomarker cytomorphology in high-risk women, and thus they provide evidence that Ki-67 may be used as a response biomarker in proof-of-principle phase II trials.

Gene_expression (expression) of Ki-67

18) Confidence 0.60 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC1929099 Disease Relevance 0.70 Pain Relevance 0

We previously showed that Ki-67 expression is higher in specimens of benign breast cells exhibiting cytologic atypia that are obtained by random periareolar fine needle aspiration (RPFNA).

Gene_expression (expression) of Ki-67

19) Confidence 0.60 Published 2007 Journal Breast Cancer Res Section Abstract Doc Link PMC1929099 Disease Relevance 0.16 Pain Relevance 0

The overall expression of Ki67 antigen (dilution 1:200; DAKO, Glostrup/Denmark) was low, but some foci with an index of 30% were identified.

Gene_expression (expression) of Ki67

20) Confidence 0.58 Published 2007 Journal BMC Neurol Section Body Doc Link PMC1780055 Disease Relevance 0.58 Pain Relevance 0.06

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