INT79282

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Context Info
Confidence 0.67
First Reported 1998
Last Reported 2011
Negated 0
Speculated 2
Reported most in Body
Documents 5
Total Number 7
Disease Relevance 5.15
Pain Relevance 0.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Tgm2) mitochondrion (Tgm2) proteinaceous extracellular matrix (Tgm2)
plasma membrane (Tgm2) transferase activity, transferring acyl groups (Tgm2) cytoplasm (Tgm2)
Anatomy Link Frequency
neurons 1
brains 1
EL4 1
mast cell 1
Tgm2 (Mus musculus)
Pain Link Frequency Relevance Heat
ischemia 4 98.64 Very High Very High Very High
palliative 2 84.52 Quite High
Inflammation 231 63.12 Quite High
cINOD 3 46.88 Quite Low
aspirin 4 39.28 Quite Low
Neurotransmitter 18 21.84 Low Low
Crohn's disease 50 5.00 Very Low Very Low Very Low
substance P 34 5.00 Very Low Very Low Very Low
cytokine 18 5.00 Very Low Very Low Very Low
spastic colon 14 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 40 100.00 Very High Very High Very High
Colitis 120 99.98 Very High Very High Very High
Neurological Disease 2 99.92 Very High Very High Very High
Neurodegenerative Disease 19 99.08 Very High Very High Very High
Cancer 150 98.88 Very High Very High Very High
Cv Unclassified Under Development 3 98.64 Very High Very High Very High
Celiac Disease 4 96.64 Very High Very High Very High
Necrosis 7 95.36 Very High Very High Very High
Malignant Neoplastic Disease 6 94.64 High High
Anaphylaxis 27 87.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, exercise may activate tTG and increase modification of food-derived peptides, leading to more IgE cross-linking and mast cell degranulation.
Positive_regulation (activate) of tTG in mast cell
1) Confidence 0.67 Published 2007 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2873610 Disease Relevance 0.59 Pain Relevance 0.07
Experimental colitis upregulates tTG and increases its activity in the ENS [23].
Positive_regulation (upregulates) of tTG associated with colitis
2) Confidence 0.67 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2909178 Disease Relevance 0.98 Pain Relevance 0.03
One week after TNBS-induction of colitis in rats, myenteric neurons display increased tTG compared to control and non-inflamed colon.
Positive_regulation (increased) of tTG in neurons associated with colitis
3) Confidence 0.67 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2909178 Disease Relevance 0.99 Pain Relevance 0.03
Moreover, the finding of detergent-resistant retention of DAB4-targeted radioactivity in EL4 tumors only when 90Y-DOTA-DAB4 was given after chemotherapy rather than by itself suggests that tumor accretion of DAB4-targeted radioactivity resulted from increased transglutaminase 2 activity [14].
Positive_regulation (increased) of transglutaminase 2 in EL4 associated with cancer
4) Confidence 0.52 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2645682 Disease Relevance 0.79 Pain Relevance 0
Tissue transglutaminase, representing one of the effector elements of apoptosis, may be induced and activated in cells following ischemia.
Spec (may) Positive_regulation (induced) of Tissue transglutaminase associated with ischemia and apoptosis
5) Confidence 0.26 Published 1998 Journal Cell. Mol. Neurobiol. Section Abstract Doc Link 9876874 Disease Relevance 0.90 Pain Relevance 0.13
Tissue transglutaminase, representing one of the effector elements of apoptosis, may be induced and activated in cells following ischemia.
Spec (may) Positive_regulation (induced) of Tissue transglutaminase associated with ischemia and apoptosis
6) Confidence 0.19 Published 1998 Journal Cell. Mol. Neurobiol. Section Abstract Doc Link 9876874 Disease Relevance 0.90 Pain Relevance 0.13
in the PS2Tg2576 mice was induced by the modulation of APP processing in the brains of these mice.

3.5.

Positive_regulation (induced) of PS2Tg2576 in brains
7) Confidence 0.01 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC3018662 Disease Relevance 0 Pain Relevance 0

General Comments

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