INT7931

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.70
First Reported 1992
Last Reported 1992
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 6
Disease Relevance 0
Pain Relevance 2.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Adra2a) plasma membrane (Adra2a) cytoplasm (Adra2a)
signal transducer activity (Adra2a)
Anatomy Link Frequency
hypothalamus 8
brainstem 2
hippocampus 2
Adra2a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Desipramine 36 99.64 Very High Very High Very High
medulla 12 98.38 Very High Very High Very High
Hippocampus 12 98.16 Very High Very High Very High
cerebral cortex 24 83.44 Quite High
agonist 6 40.92 Quite Low
Clonidine 6 39.28 Quite Low
antidepressant 6 36.48 Quite Low

|}

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In other noradrenergic brain regions (hippocampus, brainstem, and hypothalamus) but not in the corpus striatum, desipramine (7-14 days) also increased alpha 2-adrenoceptor degradation (delta k = 97-144%) and shortened the half-life of the receptor, and it tended to increase the rate of synthesis (delta r = 51-83%).
Positive_regulation (increased) of Protein_catabolism (degradation) of alpha 2-adrenoceptor in hypothalamus associated with medulla, desipramine and hippocampus
1) Confidence 0.70 Published 1992 Journal Mol. Pharmacol. Section Abstract Doc Link 1359398 Disease Relevance 0 Pain Relevance 0.48
In other noradrenergic brain regions (hippocampus, brainstem, and hypothalamus) but not in the corpus striatum, desipramine (7-14 days) also increased alpha 2-adrenoceptor degradation (delta k = 97-144%) and shortened the half-life of the receptor, and it tended to increase the rate of synthesis (delta r = 51-83%).
Positive_regulation (increased) of Protein_catabolism (degradation) of alpha 2-adrenoceptor in hypothalamus associated with medulla, desipramine and hippocampus
2) Confidence 0.50 Published 1992 Journal Mol. Pharmacol. Section Abstract Doc Link 1359398 Disease Relevance 0 Pain Relevance 0.48
In other noradrenergic brain regions (hippocampus, brainstem, and hypothalamus) but not in the corpus striatum, desipramine (7-14 days) also increased alpha 2-adrenoceptor degradation (delta k = 97-144%) and shortened the half-life of the receptor, and it tended to increase the rate of synthesis (delta r = 51-83%).
Positive_regulation (increased) of in brainstem Protein_catabolism (degradation) of alpha 2-adrenoceptor in hypothalamus associated with medulla, desipramine and hippocampus
3) Confidence 0.24 Published 1992 Journal Mol. Pharmacol. Section Abstract Doc Link 1359398 Disease Relevance 0 Pain Relevance 0.48
In other noradrenergic brain regions (hippocampus, brainstem, and hypothalamus) but not in the corpus striatum, desipramine (7-14 days) also increased alpha 2-adrenoceptor degradation (delta k = 97-144%) and shortened the half-life of the receptor, and it tended to increase the rate of synthesis (delta r = 51-83%).
Positive_regulation (increased) of in hippocampus Protein_catabolism (degradation) of alpha 2-adrenoceptor in hypothalamus associated with medulla, desipramine and hippocampus
4) Confidence 0.24 Published 1992 Journal Mol. Pharmacol. Section Abstract Doc Link 1359398 Disease Relevance 0 Pain Relevance 0.48
In other noradrenergic brain regions (hippocampus, brainstem, and hypothalamus) but not in the corpus striatum, desipramine (7-14 days) also increased alpha 2-adrenoceptor degradation (delta k = 97-144%) and shortened the half-life of the receptor, and it tended to increase the rate of synthesis (delta r = 51-83%).
Positive_regulation (increased) of in hippocampus Protein_catabolism (degradation) of alpha 2-adrenoceptor in hypothalamus associated with medulla, desipramine and hippocampus
5) Confidence 0.17 Published 1992 Journal Mol. Pharmacol. Section Abstract Doc Link 1359398 Disease Relevance 0 Pain Relevance 0.48
In other noradrenergic brain regions (hippocampus, brainstem, and hypothalamus) but not in the corpus striatum, desipramine (7-14 days) also increased alpha 2-adrenoceptor degradation (delta k = 97-144%) and shortened the half-life of the receptor, and it tended to increase the rate of synthesis (delta r = 51-83%).
Positive_regulation (increased) of in brainstem Protein_catabolism (degradation) of alpha 2-adrenoceptor in hypothalamus associated with medulla, desipramine and hippocampus
6) Confidence 0.17 Published 1992 Journal Mol. Pharmacol. Section Abstract Doc Link 1359398 Disease Relevance 0 Pain Relevance 0.48

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox