INT79313

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Context Info
Confidence 0.49
First Reported 1998
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.27
Pain Relevance 0.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (PDIA3) protein folding (PDIA3) signal transduction (PDIA3)
endoplasmic reticulum (PDIA3)
Anatomy Link Frequency
KG-1 1
PDIA3 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 1 99.82 Very High Very High Very High
opioid receptor 2 98.70 Very High Very High Very High
Opioid 1 92.24 High High
spinal inflammation 14 5.00 Very Low Very Low Very Low
Arthritis 5 5.00 Very Low Very Low Very Low
Inflammation 3 5.00 Very Low Very Low Very Low
imagery 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cytomegalovirus Infection 1 98.68 Very High Very High Very High
Bordatella Infection 2 93.32 High High
Low Back Pain 14 5.00 Very Low Very Low Very Low
Disease 7 5.00 Very Low Very Low Very Low
Targeted Disruption 5 5.00 Very Low Very Low Very Low
Arthritis 4 5.00 Very Low Very Low Very Low
Seronegative Spondarthritis 1 5.00 Very Low Very Low Very Low
Viral Infection 1 5.00 Very Low Very Low Very Low
Stress 1 5.00 Very Low Very Low Very Low
Infection 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In COS-7 cells coexpressing one of the three opioid receptors (mu, delta, and kappa) and a Galpha(q) chimera, agonist-induced stimulation of phosphoinositide-specific phospholipase C (PI-PLC) was largely insensitive to PTX treatment.
Positive_regulation (stimulation) of PI-PLC associated with agonist and opioid receptor
1) Confidence 0.49 Published 1998 Journal FEBS Lett. Section Abstract Doc Link 9877167 Disease Relevance 0.17 Pain Relevance 0.23
This may reflect the increase in expression of components of the MHC class I assembly pathway, such as ERp57 and tapasin, which we have previously shown to increase with KG-1 maturation [20].
Positive_regulation (increase) of ERp57 in KG-1
2) Confidence 0.10 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575614 Disease Relevance 0.10 Pain Relevance 0

General Comments

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