INT79343

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Context Info
Confidence 0.50
First Reported 1999
Last Reported 2009
Negated 0
Speculated 1
Reported most in Abstract
Documents 10
Total Number 12
Disease Relevance 1.77
Pain Relevance 4.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Slc6a4) endosome (Slc6a4) plasma membrane (Slc6a4)
Anatomy Link Frequency
neuronal 1
brain 1
smooth muscle cells 1
lung 1
midbrain 1
Slc6a4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Serotonin 56 100.00 Very High Very High Very High
withdrawal 9 99.92 Very High Very High Very High
Eae 1 99.36 Very High Very High Very High
midbrain 6 98.88 Very High Very High Very High
noradrenaline 6 98.52 Very High Very High Very High
Hippocampus 33 98.36 Very High Very High Very High
antidepressant 9 97.88 Very High Very High Very High
fluoxetine 21 96.72 Very High Very High Very High
Dynorphin 1 94.64 High High
Raphe 6 90.68 High High
Disease Link Frequency Relevance Heat
Manic Depressive Disorder 4 99.96 Very High Very High Very High
Hypoxia 7 99.84 Very High Very High Very High
Depression 26 98.60 Very High Very High Very High
Urological Neuroanatomy 17 95.24 Very High Very High Very High
Syndrome 2 91.28 High High
Hypertension 20 90.76 High High
Anxiety Disorder 38 84.68 Quite High
Stress 7 61.80 Quite High
Affective Disorder 6 46.96 Quite Low
Targeted Disruption 2 30.40 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Reboxetine treatment (surprisingly) led to an even more enhanced serotonin transporter density (Bmax = 1322 +/- 46), while noradrenaline transporter density seemed to be unaffected.
Positive_regulation (enhanced) of serotonin transporter associated with noradrenaline and serotonin
1) Confidence 0.50 Published 2005 Journal World J. Biol. Psychiatry Section Abstract Doc Link 16156483 Disease Relevance 0.33 Pain Relevance 0.84
Estrogen increases serotonin transporter (SERT) mRNA and binding sites in female rat brain.
Positive_regulation (increases) of serotonin transporter in brain associated with serotonin
2) Confidence 0.50 Published 1999 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9878762 Disease Relevance 0 Pain Relevance 0.24
If the early detection of serotonin transporter messenger RNA in skin and gastrointestinal and airway epithelia correlates with protein activity, it may permit establishment of a serotonin concentration gradient across epithelia, either from serotonin in the amniotic fluid or from neuronal enteric serotonin, as a developmental cue.
Positive_regulation (detection) of serotonin transporter messenger RNA in neuronal associated with serotonin
3) Confidence 0.49 Published 1999 Journal Neuroscience Section Abstract Doc Link 10051233 Disease Relevance 0 Pain Relevance 0.64
Established PH on day 15 was associated with a sustained 5-HTT increase.
Positive_regulation (increase) of 5-HTT
4) Confidence 0.34 Published 2005 Journal Circulation Section Body Doc Link 15927991 Disease Relevance 0 Pain Relevance 0
Continued fluoxetine treatment completely prevented PA-SMC proliferation and PH development and also suppressed the late 5-HTT increase, without affecting the early peak.
Positive_regulation (increase) of 5-HTT
5) Confidence 0.34 Published 2005 Journal Circulation Section Body Doc Link 15927991 Disease Relevance 0 Pain Relevance 0
CONCLUSIONS: Upregulation of lung 5-HTT induced by MCT appears necessary to initiate the development of pulmonary vascular remodeling, whereas a sustained increase in 5-HTT expression may underlie both the progression and the maintenance of MCT-induced PH.
Positive_regulation (induced) of 5-HTT in lung
6) Confidence 0.34 Published 2005 Journal Circulation Section Body Doc Link 15927991 Disease Relevance 0 Pain Relevance 0
A significant induction of TPH2 and 5-HT transporter (5-HTT) mRNAs was detected in the midbrain of untreated rats 24 h after the swim test.
Positive_regulation (induction) of 5-HTT in midbrain associated with midbrain
7) Confidence 0.34 Published 2007 Journal Neuroscience Section Abstract Doc Link 17950541 Disease Relevance 0 Pain Relevance 1.11
It has been previously proposed that 5-HTT-mediated increases in 5-HT-ergic neurotransmission upregulate BDNF expression via increases in cAMP response element binding protein phosphorylation (Duman et al., 1997, 1999; Nibuya et al., 1996), but it has also been demonstrated that male and female mice with partial (5-HTT +/?)
Positive_regulation (increases) of 5-HTT-mediated
8) Confidence 0.28 Published 2008 Journal Brain Res Section Body Doc Link PMC2568862 Disease Relevance 0.30 Pain Relevance 0.08
Similarly, in studies on patients with bipolar disorder, 5-HTT levels have been found to be increased in medial prefrontal cortex, but not in hippocampus (Cannon et al., 2006).
Positive_regulation (increased) of 5-HTT in hippocampus associated with manic depressive disorder and hippocampus
9) Confidence 0.28 Published 2008 Journal Brain Res Section Body Doc Link PMC2568862 Disease Relevance 0.26 Pain Relevance 0.13
Changes in the serotonin transporter (SERT) have also been reported in MDD, and changes in the immediate early gene c-fos have been observed in the context of psychostimulant withdrawal.
Positive_regulation (Changes) of serotonin transporter associated with depression, withdrawal and serotonin
10) Confidence 0.18 Published 2009 Journal Synapse Section Abstract Doc Link 19116947 Disease Relevance 0.47 Pain Relevance 0.45
Induction of serotonin transporter by hypoxia in pulmonary vascular smooth muscle cells.
Positive_regulation (Induction) of serotonin transporter in smooth muscle cells associated with hypoxia and serotonin
11) Confidence 0.15 Published 1999 Journal Circ. Res. Section Title Doc Link 10024307 Disease Relevance 0.40 Pain Relevance 0.25
Although these data should be interpreted cautiously due to the small sample size, these results implicate TPH1 and SLC6A4 in general response, and HTR2A, TPH2, and MAOA in the specificity of response to fluoxetine.
Spec (implicate) Positive_regulation (implicate) of SLC6A4 associated with fluoxetine
12) Confidence 0.09 Published 2004 Journal Mol. Psychiatry Section Abstract Doc Link 15052272 Disease Relevance 0 Pain Relevance 0.31

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