INT79344

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Context Info
Confidence 0.33
First Reported 1999
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 0.61
Pain Relevance 0.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Cyp19a1) endoplasmic reticulum (Cyp19a1) cytoplasm (Cyp19a1)
Anatomy Link Frequency
brain 1
Cyp19a1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 5 97.76 Very High Very High Very High
Central grey 1 94.40 High High
midbrain 1 93.88 High High
amygdala 1 86.76 High High
Raphe 3 84.16 Quite High
Serotonin 2 75.00 Quite High
anesthesia 1 60.40 Quite High
halothane 1 59.96 Quite High
antagonist 10 45.92 Quite Low
agonist 6 44.88 Quite Low
Disease Link Frequency Relevance Heat
Glioma 4 99.64 Very High Very High Very High
Reprotox - General 3 31 85.92 High High
Breast Cancer 9 85.60 High High
Congenital Anomalies 4 20.16 Low Low
Birth Weight 1 19.00 Low Low
Premature Birth 1 18.28 Low Low
Spontaneous Abortion 1 17.12 Low Low
Endometriosis (extended) 12 5.00 Very Low Very Low Very Low
Obesity 7 5.00 Very Low Very Low Very Low
Reprotox - General 1 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our findings show that testosterone is present in rat C6 glioma cells and can be metabolized by aromatase.
aromatase Binding (metabolized) of associated with glioma
1) Confidence 0.33 Published 2009 Journal J. Cell. Physiol. Section Abstract Doc Link 19492405 Disease Relevance 0.29 Pain Relevance 0.42
These data show that testosterone as well as estrogen affects SERT expression in male brain, and that the action of testosterone probably depends upon its enzymatic conversion, by aromatase, to estradiol.
aromatase Binding (depends) of in brain
2) Confidence 0.16 Published 1999 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9878762 Disease Relevance 0 Pain Relevance 0.38
Vinggaard et al. hypothesized that compounds which can inhibit aromatase acitivity in vitro may be able to cause local changes in estrogen and androgen concentrations in vivo [26].
aromatase Binding (acitivity) of
3) Confidence 0.13 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1524969 Disease Relevance 0 Pain Relevance 0
We investigated interactions between treatment and selected polymorphisms in the CYP17 and CYP19 genes, both of which are involved in the sex hormone biosynthesis pathway, and the oestrogen receptor (ESR1) gene.
CYP19 Binding (interactions) of
4) Confidence 0.10 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC400670 Disease Relevance 0.33 Pain Relevance 0

General Comments

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