INT79345

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Context Info
Confidence 0.58
First Reported 1999
Last Reported 2009
Negated 1
Speculated 0
Reported most in Abstract
Documents 8
Total Number 8
Disease Relevance 2.98
Pain Relevance 3.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
plasma 2
dorsal 2
colon 2
epithelial cells 2
Sert1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Serotonin 17 100.00 Very High Very High Very High
Raphe 3 100.00 Very High Very High Very High
imagery 3 100.00 Very High Very High Very High
withdrawal 4 98.20 Very High Very High Very High
fluoxetine 16 97.64 Very High Very High Very High
sSRI 5 95.84 Very High Very High Very High
Hyperalgesia 1 94.00 High High
anesthesia 1 92.96 High High
halothane 1 92.52 High High
Pain threshold 2 91.76 High High
Disease Link Frequency Relevance Heat
Increased Venous Pressure Under Development 23 100.00 Very High Very High Very High
Stress 5 99.88 Very High Very High Very High
Hypertension 4 99.84 Very High Very High Very High
Hypoxia 6 99.32 Very High Very High Very High
Recurrence 4 99.16 Very High Very High Very High
Pulmonary Hypertension 120 98.84 Very High Very High Very High
Pain 4 91.76 High High
Death 2 79.00 Quite High
Apoptosis 4 76.24 Quite High
Dyspepsia 4 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In conclusion, SERT overexpression correlates with the recurrence of PAH after withdrawal of fluoxetine in rats.
Positive_regulation (overexpression) of Gene_expression (overexpression) of SERT associated with pulmonary hypertension, withdrawal, recurrence and fluoxetine
1) Confidence 0.58 Published 2009 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 19473340 Disease Relevance 0.77 Pain Relevance 0.86
Furthermore, EA decreased 5-HT concentration in colon in rats with CVH and CVH rats with water avoidance stress, and increased the 5-HT(4a) and SERT expression in rats with CVH.
Positive_regulation (increased) of Gene_expression (expression) of SERT in colon associated with stress
2) Confidence 0.54 Published 2006 Journal Brain Res. Section Abstract Doc Link 16650387 Disease Relevance 0.84 Pain Relevance 0.63
Chronic treatment with SERT substrates (5-HT, 3,4-methylenedioxymethamphetamine) increased both peak SERT protein levels (fourfold) and the time course of SERT expression.
Positive_regulation (increased) of Gene_expression (expression) of SERT
3) Confidence 0.50 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 11756522 Disease Relevance 0 Pain Relevance 0.29
In conclusion, it can be estimated that imaging of the human SERT in a high-density region requires radioligands with Kd values between 0.03 and a maximum of 0.3 nM (at 37 degrees C).
Positive_regulation (requires) of Gene_expression (imaging) of SERT associated with imagery
4) Confidence 0.41 Published 2007 Journal Synapse Section Abstract Doc Link 17657807 Disease Relevance 0 Pain Relevance 0.28
The number of SERT mRNA-expressing cells in the dorsal raphe (DR) nucleus was decreased by castration and increased by treatment (for approximately 32 h) with EB or TP, but not 5alpha-DHT.
Neg (not) Positive_regulation (increased) of Gene_expression (expressing) of SERT in dorsal associated with raphe
5) Confidence 0.40 Published 1999 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9878762 Disease Relevance 0 Pain Relevance 0.44
Pulmonary arterial 5-hydroxytryptamine (serotonin) (5-HT) transporter (SERT)-, 5-HT receptor expression, and 5-HT-induced vasoconstriction can be increased in pulmonary hypertension.
Positive_regulation (increased) of Gene_expression (expression) of SERT associated with hypertension, increased venous pressure under development and serotonin
6) Confidence 0.40 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15659538 Disease Relevance 0.44 Pain Relevance 0.19
The experiments were performed using the JAR cell line that constitutively expresses high levels of SERT, and rat intestine, whose mucosal epithelial cells also express SERT.
Positive_regulation (levels) of Gene_expression (expresses) of SERT in epithelial cells
7) Confidence 0.40 Published 2004 Journal Life Sci. Section Abstract Doc Link 15501483 Disease Relevance 0 Pain Relevance 0.21
Research has found that patients with PAH have increased plasma serotonin levels,118 and that over-expression of the serotonin transporter gene (SERT) increases PA pressure.119 Hypoxia and monocrotaline-induced PAH in animals has been shown to be inhibited by the selective serotonin reuptake inhibitor (SSRI), fluoxetine.120,121 So far however, studies in humans have not produced statistically significant results.122

l-Arginine

Positive_regulation (increases) of Gene_expression (expression) of SERT in plasma associated with pulmonary hypertension, hypoxia, ssri, serotonin and fluoxetine
8) Confidence 0.04 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2697585 Disease Relevance 0.93 Pain Relevance 0.38

General Comments

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