INT79347

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Context Info
Confidence 0.54
First Reported 1999
Last Reported 2009
Negated 1
Speculated 0
Reported most in Abstract
Documents 9
Total Number 9
Disease Relevance 2.57
Pain Relevance 3.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
colon 2
neurons 2
brain 2
brainstem 2
bowel 2
Sert1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Serotonin 13 100.00 Very High Very High Very High
medulla 2 100.00 Very High Very High Very High
Raphe 12 99.40 Very High Very High Very High
depression 2 99.00 Very High Very High Very High
agonist 5 98.80 Very High Very High Very High
withdrawal 21 98.70 Very High Very High Very High
antagonist 4 98.28 Very High Very High Very High
Central grey 3 97.76 Very High Very High Very High
midbrain 1 97.24 Very High Very High Very High
Hippocampus 11 97.08 Very High Very High Very High
Disease Link Frequency Relevance Heat
Right Ventricular Hypertrophy 1 99.78 Very High Very High Very High
Depression 12 99.00 Very High Very High Very High
Syndrome 7 98.36 Very High Very High Very High
Dyspepsia 6 95.60 Very High Very High Very High
Pain 2 93.96 High High
Urological Neuroanatomy 12 91.12 High High
Stress 6 88.80 High High
Pulmonary Hypertension 14 82.72 Quite High
Functional Bowel Disorder 3 79.04 Quite High
Recurrence 4 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We tested the hypothesis that developmental expression of SERT in thalamocortical neurons is regulated by psychostimulants that are agonists and antagonists of SERT.
Regulation (regulated) of Gene_expression (expression) of SERT in neurons associated with antagonist and agonist
1) Confidence 0.54 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 11756522 Disease Relevance 0 Pain Relevance 0.14
CONCLUSION: CJA has therapeutic effect for improving visceral hypersensitivity in irritable bowel syndrome by way of regulating colonic expression of SERT and content of 5-HT.


Regulation (regulating) of Gene_expression (expression) of SERT in bowel
2) Confidence 0.52 Published 2008 Journal Zhongguo Zhong Xi Yi Jie He Za Zhi Section Body Doc Link 19065896 Disease Relevance 0 Pain Relevance 0
These data show that testosterone as well as estrogen affects SERT expression in male brain, and that the action of testosterone probably depends upon its enzymatic conversion, by aromatase, to estradiol.
Regulation (affects) of Gene_expression (expression) of SERT in brain
3) Confidence 0.50 Published 1999 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9878762 Disease Relevance 0 Pain Relevance 0.42
Morphometric changes, pulmonary arterial pressure, percentage wall thickness, right ventricular hypertrophy index and SERT expression were detected at various times during the 12 week treatment period.
Regulation (detected) of Gene_expression (expression) of SERT associated with right ventricular hypertrophy
4) Confidence 0.43 Published 2009 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 19473340 Disease Relevance 0.79 Pain Relevance 0.68
In addition, the effect of EA on 5-HT(4a) receptor and serotonin transporter (SERT) expression in the colon mucosa was analyzed semi-quantitatively through immunohistochemistry and 5-HT concentration in the colon tissue was observed through spectro-photo-fluorimeter detection, respectively.
Regulation (effect) of Gene_expression (expression) of SERT in colon associated with serotonin
5) Confidence 0.35 Published 2006 Journal Brain Res. Section Abstract Doc Link 16650387 Disease Relevance 0.90 Pain Relevance 0.69
This study examined the effects of chronic, escalating doses of D-AMPH followed by 24 h of withdrawal on the expression of prodynorphin (PD) and c-fos mRNA in limbic regions of the brain, caudate putamen (CPu), and brainstem and SERT mRNA expression in the dorsal raphe nucleus (DRN).
Regulation (regions) of Gene_expression (expression) of SERT mRNA in brainstem associated with medulla, raphe and withdrawal
6) Confidence 0.34 Published 2009 Journal Synapse Section Abstract Doc Link 19116947 Disease Relevance 0.47 Pain Relevance 0.64
Alterations in PD, c-fos, and SERT expression could contribute to the depression-like syndrome associated with psychostimulant withdrawal.
Regulation (Alterations) of Gene_expression (expression) of SERT associated with depression, syndrome and withdrawal
7) Confidence 0.34 Published 2009 Journal Synapse Section Abstract Doc Link 19116947 Disease Relevance 0.34 Pain Relevance 0.66
These data (1) show that endogenous SERT is differentially regulated by 5-HT and psychostimulants, (2) indicate that SERT modulation occurs via changes in both total SERT protein levels and subcellular redistribution of the transporter, and (3) suggest that some of the actions of drugs of abuse in neocortical development may be attributable to alterations in SERT expression and concomitant changes in 5-HT signaling.
Regulation (alterations) of Gene_expression (expression) of SERT
8) Confidence 0.27 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 11756522 Disease Relevance 0 Pain Relevance 0.26
Thus, doses of MDMA that deplete tissue 5-HT do not alter expression of SERT or GFAP.
Neg (not) Regulation (alter) of Gene_expression (expression) of SERT
9) Confidence 0.17 Published 2006 Journal Psychopharmacology (Berl) Section Body Doc Link PMC1705495 Disease Relevance 0.07 Pain Relevance 0.08

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