INT79355

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Context Info
Confidence 0.40
First Reported 1999
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 6
Disease Relevance 3.46
Pain Relevance 1.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
respiratory 2
neutrophil leukocytes 1
Lar (Mus musculus)
Pain Link Frequency Relevance Heat
opioid receptor 3 93.84 High High
analgesia 14 93.76 High High
Inflammation 25 92.60 High High
Opioid 3 89.28 High High
Inflammatory mediators 10 88.04 High High
Potency 2 84.28 Quite High
Analgesic 3 83.96 Quite High
Inflammatory marker 15 72.80 Quite High
agonist 1 67.80 Quite High
Enkephalin 2 63.76 Quite High
Disease Link Frequency Relevance Heat
Infection 15 98.76 Very High Very High Very High
Esophageal Cancer 60 96.84 Very High Very High Very High
Respiratory Failure 30 96.68 Very High Very High Very High
Syndrome 40 94.28 High High
INFLAMMATION 50 92.60 High High
Critical Illness 5 90.84 High High
Multiple Organ Failure 30 79.40 Quite High
Sepsis 15 79.08 Quite High
Lung Injury 15 77.56 Quite High
Bronchopneumonia 5 77.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Surprisingly, differences in these in vitro markers were often in the direction of LAR>HAR.
Positive_regulation (direction) of LAR
1) Confidence 0.40 Published 1999 Journal Brain Res. Section Abstract Doc Link 9878841 Disease Relevance 0.07 Pain Relevance 1.44
The main message of this recent observation is that the detection of increasing PCT and LAR values, even without signs of infection, can be regarded as a hint at forthcoming respiratory insufficiency and, later on, other complications.
Positive_regulation (increasing) of LAR in respiratory associated with respiratory failure and infection
2) Confidence 0.05 Published 2006 Journal Crit Care Section Body Doc Link PMC1750987 Disease Relevance 0.95 Pain Relevance 0.03
These results suggest that an elevated LAR (>15%) and an elevated procalcitonin concentration (>2.5 ng/ml) measured on the second postoperative day can predict next-day arterial hypoxaemia (PaO2/FIO2 < 300 mmHg) after oesophageal tumour resection.



Positive_regulation (elevated) of LAR associated with esophageal cancer
3) Confidence 0.04 Published 2006 Journal Crit Care Section Abstract Doc Link PMC1750987 Disease Relevance 0.22 Pain Relevance 0
It has been proven that an elevated LAR is in positive correlation with enhanced leukocyte adherence [6], with an increased cell volume and higher vacuole content of neutrophil leukocytes [7], and with the severity of systemic inflammatory reaction syndrome (SIRS) in critically ill patients [5].
Positive_regulation (elevated) of LAR in neutrophil leukocytes associated with inflammation, critical illness and syndrome
4) Confidence 0.04 Published 2006 Journal Crit Care Section Body Doc Link PMC1750987 Disease Relevance 0.99 Pain Relevance 0.16
This recent study demonstrates that an elevated LAR (>15%) and an elevated PCT level (>2.5 ng/ml) measured on the second postoperative day can predict next-day arterial hypoxaemia as one of the early signs of threatening respiratory complication after oesophageal tumour resection.
Positive_regulation (elevated) of LAR in respiratory associated with esophageal cancer
5) Confidence 0.04 Published 2006 Journal Crit Care Section Body Doc Link PMC1750987 Disease Relevance 0.27 Pain Relevance 0
An elevated PCT level and, especially, an elevated LAR indicate forthcoming arterial hypoxaemia in the early postoperative period of oesophageal tumour resections.


Positive_regulation (elevated) of LAR associated with esophageal cancer
6) Confidence 0.03 Published 2006 Journal Crit Care Section Body Doc Link PMC1750987 Disease Relevance 0.95 Pain Relevance 0.12

General Comments

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