INT79365

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Context Info
Confidence 0.41
First Reported 1998
Last Reported 2001
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.16
Pain Relevance 1.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Pnoc) plasma membrane (Oprl1) signal transducer activity (Oprl1)
Anatomy Link Frequency
nerve 1
Pnoc (Rattus norvegicus)
Oprl1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
orphanin 17 100.00 Very High Very High Very High
narcan 4 100.00 Very High Very High Very High
antagonist 4 100.00 Very High Very High Very High
noradrenaline 4 99.84 Very High Very High Very High
intrathecal 5 99.48 Very High Very High Very High
Opioid 2 94.68 High High
opioid receptor 3 89.96 High High
Spinal cord 2 88.56 High High
withdrawal 1 87.52 High High
agonist 1 60.56 Quite High
Disease Link Frequency Relevance Heat
Nociception 3 82.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
ORL1 receptor-mediated inhibition by nociceptin of noradrenaline release from perivascular sympathetic nerve endings of the rat tail artery.
nociceptin Negative_regulation (inhibition) of ORL1 in nerve associated with orphanin, narcan and noradrenaline
1) Confidence 0.41 Published 1998 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Title Doc Link 9879729 Disease Relevance 0 Pain Relevance 0.89
The intrathecal nociceptin-induced increases in HWL were antagonized by intrathecal administration of (Nphe1)Nociceptin(1-13)-NH(2), a selective antagonist of ORL1 receptor, in a dose-dependent manner.
Nociceptin Negative_regulation (antagonist) of ORL1 receptor associated with antagonist, orphanin and intrathecal
2) Confidence 0.37 Published 2001 Journal Regul. Pept. Section Abstract Doc Link 11495682 Disease Relevance 0.16 Pain Relevance 0.84

General Comments

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