INT79395

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Context Info
Confidence 0.77
First Reported 1999
Last Reported 2010
Negated 6
Speculated 1
Reported most in Body
Documents 193
Total Number 197
Disease Relevance 100.06
Pain Relevance 26.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Twist1) nucleus (Twist1) DNA binding (Twist1)
transcription factor binding (Twist1)
Anatomy Link Frequency
Th1 cells 28
lymphocytes 6
Th2 cells 6
T cells 6
lung 3
Twist1 (Mus musculus)
Pain Link Frequency Relevance Heat
ischemia 20 100.00 Very High Very High Very High
Inflammatory response 202 99.98 Very High Very High Very High
Inflammation 5038 99.96 Very High Very High Very High
Arthritis 1440 99.96 Very High Very High Very High
Migraine 16 99.96 Very High Very High Very High
Pain 166 99.92 Very High Very High Very High
corticosteroid 89 99.90 Very High Very High Very High
long-term potentiation 54 99.76 Very High Very High Very High
cytokine 2444 99.70 Very High Very High Very High
Snapping jaw 15 99.68 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 3369 100.00 Very High Very High Very High
Age-related Macular Degeneration 1416 100.00 Very High Very High Very High
Apoptosis 1011 100.00 Very High Very High Very High
Skin Cancer 370 100.00 Very High Very High Very High
Keratosis 140 100.00 Very High Very High Very High
Recurrence 81 100.00 Very High Very High Very High
Mycosis Fungoides 17 100.00 Very High Very High Very High
Cv Unclassified Under Development 11 100.00 Very High Very High Very High
Epilepsy 10 100.00 Very High Very High Very High
INFLAMMATION 5261 99.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Among murine CD4+CD62Llo memory-phenotype Th cells that were isolated from spleen or lymph nodes of naive DO11.10 mice, expression of twist1 is low.
Gene_expression (expression) of twist1 in lymph nodes
1) Confidence 0.77 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2525589 Disease Relevance 0.14 Pain Relevance 0.07
Adoptive transfer of Th1 cells versus Th1 cells with a shRNA-mediated knockdown of twist1 expression demonstrates the relevance of twist1 expression by Th1 cells for the control of immunopathology.
Gene_expression (expression) of twist1 in Th1 cells
2) Confidence 0.77 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2525589 Disease Relevance 0.68 Pain Relevance 0.32
In this study, we have identified twist1 as a gene that is differentially expressed by Th1 cells versus Th2 cells, comparing the transcriptomes of once and repeatedly restimulated murine Th1 and Th2 cells generated in vitro from bona fide naive Th cells.
Gene_expression (expressed) of twist1 in Th2 cells
3) Confidence 0.77 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2525589 Disease Relevance 0.18 Pain Relevance 0.10
Remarkably, expression of twist1 is highly up-regulated in CD3+CD4+ T cells isolated from inflamed tissues of patients with chronic inflammation of joints or gut.
Gene_expression (expression) of twist1 in T cells associated with inflammation
4) Confidence 0.77 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2525589 Disease Relevance 0.10 Pain Relevance 0.05
Twist1 and twist2 are expressed by fibroblasts and macrophages, and expression is promoted by TNF-?
Gene_expression (expressed) of Twist1 in macrophages
5) Confidence 0.77 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2525589 Disease Relevance 1.24 Pain Relevance 0.43
Expression of twist1 follows TCR stimulation transiently and increases upon repeated stimulation.
Gene_expression (Expression) of twist1
6) Confidence 0.77 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2525589 Disease Relevance 0.42 Pain Relevance 0.16
Accordingly, ectopic twist1 expression in Th1 cells right from the beginning impairs their function in acute inflammation of DTH.
Gene_expression (expression) of twist1 in Th1 cells associated with inflammation and hypersensitivity
7) Confidence 0.77 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2525589 Disease Relevance 0.86 Pain Relevance 0.28
Accordingly, in Th cells isolated ex vivo, twist1 expression is restricted to a subset of memory cells.
Gene_expression (expression) of twist1
8) Confidence 0.77 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2525589 Disease Relevance 0.15 Pain Relevance 0.08
/STAT1, is required to induce twist1 expression.
Gene_expression (expression) of twist1
9) Confidence 0.77 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2525589 Disease Relevance 0.05 Pain Relevance 0.03
B have to bind to the promoter of twist1 in Th cells to induce expression, i.e., twist1 is expressed only by activated Th cells.
Gene_expression (expressed) of twist1
10) Confidence 0.77 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2525589 Disease Relevance 0.21 Pain Relevance 0.10
In activated macrophages, type I IFNs induce the expression of twist1 (5), and they express both twist genes, i.e., twist1 and twist2, whereas activated Th1 cells exclusively express twist1.
Gene_expression (express) of twist1 in Th1 cells
11) Confidence 0.77 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2525589 Disease Relevance 0.07 Pain Relevance 0.03
For the initial expression of twist1 in Th1 cells, and its imprinting for reexpression in further restimulations, the concerted action of activated STAT4, NFAT1, and NF-?
Gene_expression (expression) of twist1 in Th1 cells
12) Confidence 0.77 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2525589 Disease Relevance 0 Pain Relevance 0
Expression of twist1 in Th cells is induced by IL-12/STAT4, NF-?
Gene_expression (Expression) of twist1
13) Confidence 0.77 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2525589 Disease Relevance 0.68 Pain Relevance 0.29
The requirement of NFAT for induction of twist1 expression in Th1 cells distinguishes control of twist1 expression in Th cells from its control in fibroblasts, where TNF-?
Gene_expression (expression) of twist1 in Th1 cells
14) Confidence 0.77 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2525589 Disease Relevance 0 Pain Relevance 0
Th cell–specific twist1 expression in vivo
Gene_expression (expression) of twist1
15) Confidence 0.77 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2525589 Disease Relevance 0.06 Pain Relevance 0
Expression of twist1 increases upon repeated restimulation in vitro in Th1 cells, whereas it is not induced even in repeatedly restimulated Th2 or Th17 cells.
Gene_expression (Expression) of twist1 in Th1 cells
16) Confidence 0.77 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2525589 Disease Relevance 0.17 Pain Relevance 0.09
Because twist1 is expressed transiently upon activation of Th1 cells, we investigated whether signals from the TCR are involved in twist1 expression control.
Gene_expression (expressed) of twist1 in Th1 cells
17) Confidence 0.77 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2525589 Disease Relevance 0 Pain Relevance 0
The requirement of NFAT for induction of twist1 expression in Th1 cells distinguishes control of twist1 expression in Th cells from its control in fibroblasts, where TNF-?
Gene_expression (expression) of twist1 in fibroblasts
18) Confidence 0.77 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2525589 Disease Relevance 0 Pain Relevance 0
When analyzed on day 21 after transfer, mice with a knockdown of twist1 expression in Th1 cells showed increased hyperplasia of the lining cells and synovial fibroblasts in the sublining layer, pannus formation, and vascularization.
Gene_expression (expression) of twist1 in Th1 cells associated with hyperplasia
19) Confidence 0.77 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2525589 Disease Relevance 0.70 Pain Relevance 0.22
Adoptive transfer of Th1 cells versus Th1 cells with a shRNA-mediated knockdown of twist1 expression demonstrates the relevance of twist1 expression by Th1 cells for the control of immunopathology.
Gene_expression (expression) of twist1 in Th1 cells
20) Confidence 0.77 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2525589 Disease Relevance 0.67 Pain Relevance 0.29

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