INT79399

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Context Info
Confidence 0.70
First Reported 1999
Last Reported 2008
Negated 1
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 2.83
Pain Relevance 2.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Pde4d) Golgi apparatus (Pde4d) plasma membrane (Pde4d)
cytoskeleton (Pde4d) cytoplasm (Pde4d)
Anatomy Link Frequency
immune cells 1
brain 1
lungs 1
frontal cortex 1
Pde4d (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antidepressant 14 99.62 Very High Very High Very High
Inflammation 46 99.44 Very High Very High Very High
Pain 6 99.44 Very High Very High Very High
IPN 2 99.04 Very High Very High Very High
Analgesic 2 97.40 Very High Very High Very High
monoamine 2 97.24 Very High Very High Very High
Desipramine 2 96.68 Very High Very High Very High
fluoxetine 2 95.40 Very High Very High Very High
Serotonin 2 94.32 High High
acular 2 93.24 High High
Disease Link Frequency Relevance Heat
Convulsion 2 99.92 Very High Very High Very High
INFLAMMATION 40 99.14 Very High Very High Very High
Inflammatory Pain 2 99.04 Very High Very High Very High
Cancer 2 98.28 Very High Very High Very High
Necrosis 2 98.04 Very High Very High Very High
Urological Neuroanatomy 2 97.44 Very High Very High Very High
Hyperoxia 49 94.84 High High
Asthma 4 86.72 High High
Pulmonary Disease 6 85.84 High High
Disease 1 80.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Expression of PDE4A and PDE4B, but not PDE4D, mRNA and immunoreactivity were significantly increased in rat frontal cortex by chronic administration of each of the four classes of antidepressants.
Gene_expression (Expression) of PDE4D in frontal cortex associated with antidepressant and urological neuroanatomy
1) Confidence 0.70 Published 1999 Journal J. Neurosci. Section Abstract Doc Link 9880581 Disease Relevance 0.20 Pain Relevance 0.52
The influence of chronic antidepressant administration on expression of the three major phosphodiesterase (PDE) 4 subtypes found in brain (PDE4A, PDE4B, and PDE4D) was examined.
Gene_expression (expression) of PDE4D in brain associated with antidepressant
2) Confidence 0.54 Published 1999 Journal J. Neurosci. Section Abstract Doc Link 9880581 Disease Relevance 0.15 Pain Relevance 0.44
They both, however, downregulated the gene and protein expression of phosphodiesterase type 4 (PDE4D), which might represent a novel mechanism contributing to their analgesic and anti-inflammatory effects.
Gene_expression (expression) of PDE4D associated with inflammation and analgesic
3) Confidence 0.48 Published 2008 Journal Clin. Pharmacol. Ther. Section Abstract Doc Link 18288087 Disease Relevance 0.42 Pain Relevance 0.40
Whereas PDE4C is absent from adult lungs, PDE4A, 4B, and PDE4D RNAs are expressed in lungs [16].
Neg (absent) Gene_expression (expressed) of PDE4D in lungs
4) Confidence 0.48 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2563688 Disease Relevance 0.35 Pain Relevance 0
COX inhibitors downregulate PDE4D expression in a clinical model of inflammatory pain.
Gene_expression (expression) of PDE4D associated with inflammation and ipn
5) Confidence 0.42 Published 2008 Journal Clin. Pharmacol. Ther. Section Title Doc Link 18288087 Disease Relevance 0.39 Pain Relevance 0.84
Cilomilast shows high selectivity for cAMP-specific PDE4, an isoenzyme that predominates in pro-inflammatory and immune cells and that is 10-fold more selective for PDE4D than for PDE4A, -B or -C.
Gene_expression (selective) of PDE4D in immune cells associated with inflammation
6) Confidence 0.13 Published 2007 Journal Expert Opin Investig Drugs Section Abstract Doc Link 17155857 Disease Relevance 1.32 Pain Relevance 0.31

General Comments

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