INT794

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Context Info
Confidence 0.57
First Reported 1978
Last Reported 2008
Negated 1
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 1.61
Pain Relevance 0.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (DECR1) small molecule metabolic process (DECR1) nucleolus (DECR1)
nucleus (DECR1) cytoplasm (DECR1)
Anatomy Link Frequency
neurons 1
phagocyte 1
DECR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Neurotransmitter 4 95.32 Very High Very High Very High
Codeine 2 84.72 Quite High
cerebral cortex 1 83.16 Quite High
antagonist 2 75.00 Quite High
Enkephalin 1 74.32 Quite High
amygdala 1 68.48 Quite High
Angina 1 67.00 Quite High
Glutamate 1 57.84 Quite High
Central nervous system 1 42.36 Quite Low
headache 1 30.80 Quite Low
Disease Link Frequency Relevance Heat
Disease 5 99.42 Very High Very High Very High
Movement Disorders 1 98.36 Very High Very High Very High
Neutrophil Disorders 5 97.76 Very High Very High Very High
Granuloma 1 93.68 High High
Infection 3 93.12 High High
Coronary Artery Disease 6 92.72 High High
Cv General 3 Under Development 1 67.00 Quite High
Myocardial Infarction 1 66.24 Quite High
Toxicity 2 53.76 Quite High
Neurological Disease 1 32.24 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We suggest that such a protective effect may be ascribable to a reduced 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA R) activity, a statin-like effect, as well as to a downregulation in NADPH oxidase activity with a consequent reduction in oxygen-free radical production.
Negative_regulation (downregulation) of NADPH
1) Confidence 0.57 Published 2008 Journal J. Inherit. Metab. Dis. Section Abstract Doc Link 18392752 Disease Relevance 0.60 Pain Relevance 0.07
Following the finding that interferon gamma-1b (IFN gamma-1b) can potentiate phagocyte activity in some other disease states as well as restoring defective phagocyte NADPH oxidase system activity in at least some patients with chronic granulomatous disease, a large-scale placebo-controlled trial was undertaken with IFN gamma-1b in patients with chronic granulomatous disease.
Negative_regulation (defective) of NADPH in phagocyte associated with disease and neutrophil disorders
2) Confidence 0.42 Published 1992 Journal Drugs Section Abstract Doc Link 1372855 Disease Relevance 0.76 Pain Relevance 0
The two compounds are quite inactive on NADPH and NADH cytochrome c reductase activities, but slightly denature the cytochrome P450 into cytochrome P420.
Neg (inactive) Negative_regulation (inactive) of NADPH
3) Confidence 0.41 Published 1978 Journal Int. J. Radiat. Biol. Relat. Stud. Phys. Chem. Med. Section Abstract Doc Link 98466 Disease Relevance 0 Pain Relevance 0.08
Intrastriatal QUIN produces a profound loss of the NADPH diaphorase staining neurons in the area of injection but relatively spares these in the adjacent transition zone.
Negative_regulation (loss) of NADPH in neurons
4) Confidence 0.41 Published 1994 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 7736338 Disease Relevance 0.25 Pain Relevance 0.33

General Comments

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