INT79401

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Context Info
Confidence 0.59
First Reported 1999
Last Reported 2010
Negated 2
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 1.26
Pain Relevance 1.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Pde4b) signal transduction (Pde4b) nucleus (Pde4b)
cytoplasm (Pde4b)
Anatomy Link Frequency
brain 2
Pde4b (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antidepressant 21 100.00 Very High Very High Very High
cocaine 3 97.28 Very High Very High Very High
addiction 3 95.36 Very High Very High Very High
Nucleus accumbens 3 93.96 High High
fluoxetine 5 89.60 High High
Serotonin 3 88.08 High High
Desipramine 3 83.52 Quite High
monoamine 3 82.24 Quite High
Disease Link Frequency Relevance Heat
Disease 1 94.60 High High
Urological Neuroanatomy 9 92.68 High High
Convulsion 3 80.96 Quite High
Schizophrenia 1 68.56 Quite High
Manic Depressive Disorder 1 67.80 Quite High
Autism 1 67.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The influence of chronic antidepressant administration on expression of the three major phosphodiesterase (PDE) 4 subtypes found in brain (PDE4A, PDE4B, and PDE4D) was examined.
Regulation (influence) of Gene_expression (expression) of PDE4B in brain associated with antidepressant
1) Confidence 0.59 Published 1999 Journal J. Neurosci. Section Abstract Doc Link 9880581 Disease Relevance 0.14 Pain Relevance 0.43
Our results demonstrate altered expression of PDE4A and PDE4B in response to a variety of psychotropic medications suggesting potentially new therapeutic avenues for treatment of neuropsychiatric diseases.
Regulation (altered) of Gene_expression (expression) of PDE4B associated with disease
2) Confidence 0.43 Published 2010 Journal Synapse Section Abstract Doc Link 20222156 Disease Relevance 0.79 Pain Relevance 0.17
In contrast, expression of PDE4A and PDE4B were not influenced by short-term treatment (1 or 7 d) and were not influenced by chronic administration of nonantidepressant psychotropic drugs (cocaine or haloperidol), demonstrating the time dependence and pharmacological specificity of these effects.
Neg (not) Regulation (influenced) of Gene_expression (expression) of PDE4B associated with addiction and cocaine
3) Confidence 0.26 Published 1999 Journal J. Neurosci. Section Abstract Doc Link 9880581 Disease Relevance 0.17 Pain Relevance 0.60
In contrast, expression of PDE4A and PDE4B were not influenced by short-term treatment (1 or 7 d) and were not influenced by chronic administration of nonantidepressant psychotropic drugs (cocaine or haloperidol), demonstrating the time dependence and pharmacological specificity of these effects.
Neg (not) Regulation (influenced) of Gene_expression (expression) of PDE4B associated with addiction and cocaine
4) Confidence 0.26 Published 1999 Journal J. Neurosci. Section Abstract Doc Link 9880581 Disease Relevance 0.17 Pain Relevance 0.61

General Comments

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