INT79402

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Context Info
Confidence 0.74
First Reported 1999
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 3.00
Pain Relevance 2.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Pde4b) signal transduction (Pde4b) nucleus (Pde4b)
cytoplasm (Pde4b)
Anatomy Link Frequency
brain 2
neutrophils 1
frontal cortex 1
Pde4b (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antidepressant 28 99.62 Very High Very High Very High
Nucleus accumbens 4 99.48 Very High Very High Very High
monoamine 4 97.24 Very High Very High Very High
Desipramine 4 96.68 Very High Very High Very High
fluoxetine 6 95.40 Very High Very High Very High
Serotonin 4 94.32 High High
cocaine 4 94.12 High High
addiction 4 92.20 High High
ischemia 1 84.88 Quite High
Inflammation 31 56.24 Quite High
Disease Link Frequency Relevance Heat
Convulsion 4 99.92 Very High Very High Very High
Hyperoxia 49 98.56 Very High Very High Very High
Urological Neuroanatomy 10 96.84 Very High Very High Very High
Disease 1 94.60 High High
Myocardial Infarction 2 87.92 High High
Adhesions 1 86.08 High High
Reperfusion Injury 2 85.64 High High
Coronary Artery Disease 1 84.88 Quite High
Hypoxia 1 84.68 Quite High
Necrosis 2 82.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The influence of chronic antidepressant administration on expression of the three major phosphodiesterase (PDE) 4 subtypes found in brain (PDE4A, PDE4B, and PDE4D) was examined.
Gene_expression (expression) of PDE4B in brain associated with antidepressant
1) Confidence 0.74 Published 1999 Journal J. Neurosci. Section Abstract Doc Link 9880581 Disease Relevance 0.14 Pain Relevance 0.43
Expression of PDE4A and PDE4B, but not PDE4D, mRNA and immunoreactivity were significantly increased in rat frontal cortex by chronic administration of each of the four classes of antidepressants.
Gene_expression (Expression) of PDE4B in frontal cortex associated with antidepressant and urological neuroanatomy
2) Confidence 0.74 Published 1999 Journal J. Neurosci. Section Abstract Doc Link 9880581 Disease Relevance 0.20 Pain Relevance 0.52
In contrast, expression of PDE4A and PDE4B were not influenced by short-term treatment (1 or 7 d) and were not influenced by chronic administration of nonantidepressant psychotropic drugs (cocaine or haloperidol), demonstrating the time dependence and pharmacological specificity of these effects.
Gene_expression (expression) of PDE4B associated with addiction and cocaine
3) Confidence 0.74 Published 1999 Journal J. Neurosci. Section Abstract Doc Link 9880581 Disease Relevance 0.17 Pain Relevance 0.60
Our results demonstrate altered expression of PDE4A and PDE4B in response to a variety of psychotropic medications suggesting potentially new therapeutic avenues for treatment of neuropsychiatric diseases.
Gene_expression (expression) of PDE4B associated with disease
4) Confidence 0.74 Published 2010 Journal Synapse Section Abstract Doc Link 20222156 Disease Relevance 0.78 Pain Relevance 0.17
Because PDE4 activity is high and PDE4B2 is constitutively expressed in neutrophils [26], this may be related to the lung influx and sequestration of neutrophils induced by hyperoxia in the first week of life.
Gene_expression (expressed) of PDE4B2 in neutrophils associated with hyperoxia
5) Confidence 0.70 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2563688 Disease Relevance 0.87 Pain Relevance 0.05
We also found that antidepressant administration significantly increased the expression of PDE4B mRNA in the nucleus accumbens, a brain region thought to mediate pleasure and reward that could also contribute to the anhedonia often observed in depressed patients.
Gene_expression (expression) of PDE4B in brain associated with nucleus accumbens and antidepressant
6) Confidence 0.64 Published 1999 Journal J. Neurosci. Section Abstract Doc Link 9880581 Disease Relevance 0.18 Pain Relevance 0.57
Three groups of rats were studied: vehicle controls (n=6); positive controls for infarct size reduction (ischemic preconditioning; n=6); and a group treated with the selective inhibitor of PDE-IV and TNF-alpha production, rolipram (1 mg/kg i.v. 10-min prereperfusion + 1 microg/kg per minute through 1-hr reperfusion, n=6). 4.
Gene_expression (production) of PDE-IV
7) Confidence 0.13 Published 1999 Journal Gen. Pharmacol. Section Abstract Doc Link 9888252 Disease Relevance 0.65 Pain Relevance 0.04

General Comments

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