INT79405

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Context Info
Confidence 0.78
First Reported 1999
Last Reported 2010
Negated 1
Speculated 1
Reported most in Abstract
Documents 30
Total Number 32
Disease Relevance 8.48
Pain Relevance 12.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Pde4a) nucleus (Pde4a) cytoplasm (Pde4a)
Anatomy Link Frequency
brain 2
neurons 2
dentate gyrus 1
hippocampus 1
nucleus accumbens 1
Pde4a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antidepressant 104 99.68 Very High Very High Very High
Anterior cingulate 8 99.68 Very High Very High Very High
Neurotransmitter 7 99.56 Very High Very High Very High
Hippocampus 20 99.48 Very High Very High Very High
Inflammation 67 99.14 Very High Very High Very High
fluoxetine 58 99.00 Very High Very High Very High
tetrodotoxin 6 98.44 Very High Very High Very High
sodium channel 6 98.02 Very High Very High Very High
monoamine 6 97.24 Very High Very High Very High
Desipramine 16 96.68 Very High Very High Very High
Disease Link Frequency Relevance Heat
Vomiting 28 99.96 Very High Very High Very High
Convulsion 43 99.92 Very High Very High Very High
Hyperoxia 98 99.60 Very High Very High Very High
Urological Neuroanatomy 15 99.48 Very High Very High Very High
INFLAMMATION 65 99.14 Very High Very High Very High
Depression 8 96.24 Very High Very High Very High
Disease 4 94.20 High High
Asthma 4 87.92 High High
Pulmonary Disease 7 87.04 High High
Schizophrenia 2 86.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The increase in activity was accompanied by an increase in the expression of the PDE4A variants, PDE4A5 and PDE4A1, as well as of the synaptic marker protein synapsin I.
Gene_expression (expression) of PDE4A
1) Confidence 0.78 Published 2001 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 11557100 Disease Relevance 0 Pain Relevance 0.18
There was a strong correlation between the expression of the PDE4A variants with that of synapsin I, which suggests that as neurons develop and signal transduction increases there is a regulated increase in PDE4 expression and activity.
Gene_expression (expression) of PDE4A in neurons
2) Confidence 0.78 Published 2001 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 11557100 Disease Relevance 0 Pain Relevance 0.20
The increase in activity was accompanied by an increase in the expression of the PDE4A variants, PDE4A5 and PDE4A1, as well as of the synaptic marker protein synapsin I.
Gene_expression (expression) of PDE4A1
3) Confidence 0.78 Published 2001 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 11557100 Disease Relevance 0 Pain Relevance 0.18
There was a strong correlation between the expression of the PDE4A variants with that of synapsin I, which suggests that as neurons develop and signal transduction increases there is a regulated increase in PDE4 expression and activity.
Gene_expression (expression) of PDE4 in neurons
4) Confidence 0.78 Published 2001 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 11557100 Disease Relevance 0 Pain Relevance 0.22
The increase in activity was accompanied by an increase in the expression of the PDE4A variants, PDE4A5 and PDE4A1, as well as of the synaptic marker protein synapsin I.
Gene_expression (expression) of PDE4A5
5) Confidence 0.78 Published 2001 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 11557100 Disease Relevance 0 Pain Relevance 0.18
Consistent with this interpretation, it was found that treatment with the sodium channel blocker tetrodotoxin, which inhibits depolarization-induced neurotransmitter release, reduced the expression of the PDE4A variants.
Gene_expression (expression) of PDE4A associated with tetrodotoxin, neurotransmitter and sodium channel
6) Confidence 0.78 Published 2001 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 11557100 Disease Relevance 0 Pain Relevance 0.23
To determine whether this effect is shared by antidepressants from different pharmacological classes, PDE4A expression was examined using immunoblot analyses following repeated treatment with the norepinephrine re-uptake inhibitor desipramine, the monoamine oxidase inhibitor phenelzine, the atypical antidepressant trazodone, and the serotonin reuptake inhibitor fluoxetine.
Spec (examined) Gene_expression (expression) of PDE4A associated with desipramine, antidepressant, serotonin, fluoxetine and monoamine
7) Confidence 0.77 Published 2000 Journal J. Neurochem. Section Abstract Doc Link 10693959 Disease Relevance 0 Pain Relevance 0.70
It appears that repeated treatment with antidepressant drugs from different pharmacological classes produces similar effects on the expressions of PDE4A variants in hippocampus.
Gene_expression (expressions) of PDE4A in hippocampus associated with antidepressant and hippocampus
8) Confidence 0.77 Published 2000 Journal J. Neurochem. Section Abstract Doc Link 10693959 Disease Relevance 0 Pain Relevance 0.82
In contrast, expression of PDE4A and PDE4B were not influenced by short-term treatment (1 or 7 d) and were not influenced by chronic administration of nonantidepressant psychotropic drugs (cocaine or haloperidol), demonstrating the time dependence and pharmacological specificity of these effects.
Gene_expression (expression) of PDE4A associated with addiction and cocaine
9) Confidence 0.76 Published 1999 Journal J. Neurosci. Section Abstract Doc Link 9880581 Disease Relevance 0.17 Pain Relevance 0.60
Expression of PDE4A and PDE4B, but not PDE4D, mRNA and immunoreactivity were significantly increased in rat frontal cortex by chronic administration of each of the four classes of antidepressants.
Gene_expression (Expression) of PDE4A in frontal cortex associated with antidepressant and urological neuroanatomy
10) Confidence 0.76 Published 1999 Journal J. Neurosci. Section Abstract Doc Link 9880581 Disease Relevance 0.20 Pain Relevance 0.49
The influence of chronic antidepressant administration on expression of the three major phosphodiesterase (PDE) 4 subtypes found in brain (PDE4A, PDE4B, and PDE4D) was examined.
Gene_expression (expression) of PDE4A in brain associated with antidepressant
11) Confidence 0.76 Published 1999 Journal J. Neurosci. Section Abstract Doc Link 9880581 Disease Relevance 0.14 Pain Relevance 0.43
Our results demonstrate altered expression of PDE4A and PDE4B in response to a variety of psychotropic medications suggesting potentially new therapeutic avenues for treatment of neuropsychiatric diseases.
Gene_expression (expression) of PDE4A associated with disease
12) Confidence 0.75 Published 2010 Journal Synapse Section Abstract Doc Link 20222156 Disease Relevance 0.78 Pain Relevance 0.17
Western blotting experiments showed decreased expression of PDE4A subtypes in FC following treatment with clozapine, haloperidol, lithium, and VPA.
Gene_expression (expression) of PDE4A associated with urological neuroanatomy
13) Confidence 0.75 Published 2010 Journal Synapse Section Abstract Doc Link 20222156 Disease Relevance 0.79 Pain Relevance 0.18
The effects of antidepressant treatment on the high- and low-affinity rolipram binding sites on type 4 phosphodiesterase (PDE4) were determined; previous work had shown that repeated antidepressant treatment increases the overall expression of PDE4.
Gene_expression (expression) of PDE4 associated with antidepressant
14) Confidence 0.74 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12954819 Disease Relevance 0 Pain Relevance 0.47
The significance of these changes in PDE4 expression to the antidepressant effect of fluoxetine is discussed.
Gene_expression (expression) of PDE4 associated with antidepressant and fluoxetine
15) Confidence 0.72 Published 2002 Journal Neuropharmacology Section Abstract Doc Link 12504921 Disease Relevance 0 Pain Relevance 0.83
These results show that the expression of PDE4 isozymes is modulated by a clinically relevant fluoxetine dose.
Gene_expression (expression) of PDE4 associated with fluoxetine
16) Confidence 0.72 Published 2002 Journal Neuropharmacology Section Abstract Doc Link 12504921 Disease Relevance 0 Pain Relevance 0.85
ECS increased PDE4A5 levels in the anterior cingulate and frontoparietal cortices, CA1 and dentate gyrus, whereas chronic fluoxetine or ECS treatment increased PDE4A10 levels in the hippocampus.
Gene_expression (levels) of PDE4A5 in dentate gyrus associated with convulsion, hippocampus, anterior cingulate and fluoxetine
17) Confidence 0.68 Published 2005 Journal Eur. J. Neurosci. Section Abstract Doc Link 16190900 Disease Relevance 0.53 Pain Relevance 0.65
To elucidate further the role of PDE4 isozymes, we characterized the expression and regulation of PDE4A splice variants (i.e.
Gene_expression (expression) of PDE4A10
18) Confidence 0.68 Published 2005 Journal Eur. J. Neurosci. Section Abstract Doc Link 16190900 Disease Relevance 0.21 Pain Relevance 0.37
To elucidate further the role of PDE4 isozymes, we characterized the expression and regulation of PDE4A splice variants (i.e.
Gene_expression (expression) of PDE4A1
19) Confidence 0.68 Published 2005 Journal Eur. J. Neurosci. Section Abstract Doc Link 16190900 Disease Relevance 0.21 Pain Relevance 0.37
To elucidate further the role of PDE4 isozymes, we characterized the expression and regulation of PDE4A splice variants (i.e.
Gene_expression (expression) of PDE4A
20) Confidence 0.68 Published 2005 Journal Eur. J. Neurosci. Section Abstract Doc Link 16190900 Disease Relevance 0.20 Pain Relevance 0.36

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