INT79407

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Context Info
Confidence 0.67
First Reported 1999
Last Reported 1999
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.38
Pain Relevance 1.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Pde4b) signal transduction (Pde4b) nucleus (Pde4b)
cytoplasm (Pde4b)
Anatomy Link Frequency
brain 2
frontal cortex 2
Pde4b (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Nucleus accumbens 2 99.48 Very High Very High Very High
antidepressant 14 99.40 Very High Very High Very High
monoamine 2 97.24 Very High Very High Very High
Desipramine 2 96.68 Very High Very High Very High
fluoxetine 2 95.40 Very High Very High Very High
Serotonin 2 94.32 High High
cocaine 2 71.44 Quite High
addiction 2 67.60 Quite High
Disease Link Frequency Relevance Heat
Convulsion 2 99.92 Very High Very High Very High
Urological Neuroanatomy 2 99.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Expression of PDE4A and PDE4B, but not PDE4D, mRNA and immunoreactivity were significantly increased in rat frontal cortex by chronic administration of each of the four classes of antidepressants.
Positive_regulation (increased) of Gene_expression (Expression) of PDE4B in frontal cortex associated with antidepressant and urological neuroanatomy
1) Confidence 0.67 Published 1999 Journal J. Neurosci. Section Abstract Doc Link 9880581 Disease Relevance 0.20 Pain Relevance 0.55
We also found that antidepressant administration significantly increased the expression of PDE4B mRNA in the nucleus accumbens, a brain region thought to mediate pleasure and reward that could also contribute to the anhedonia often observed in depressed patients.
Positive_regulation (increased) of Gene_expression (expression) of PDE4B in brain associated with nucleus accumbens and antidepressant
2) Confidence 0.48 Published 1999 Journal J. Neurosci. Section Abstract Doc Link 9880581 Disease Relevance 0.18 Pain Relevance 0.57

General Comments

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