INT79412

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Context Info
Confidence 0.49
First Reported 1999
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 3.73
Pain Relevance 1.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (CAMP)
Anatomy Link Frequency
sweat 4
CAMP (Homo sapiens)
Pain Link Frequency Relevance Heat
antidepressant 7 99.68 Very High Very High Very High
Inflammation 31 95.84 Very High Very High Very High
Inflammatory response 4 88.96 High High
Serotonin 1 86.08 High High
cytokine 27 85.84 High High
psoriasis 19 85.08 High High
fluoxetine 1 85.04 High High
metalloproteinase 2 84.80 Quite High
Desipramine 1 83.80 Quite High
Dismenorea 1 83.56 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 35 95.84 Very High Very High Very High
Injury 3 95.32 Very High Very High Very High
Dermatitis 28 92.48 High High
Psoriasis 45 90.24 High High
Disease 16 86.00 High High
Dysmenorrhea 1 83.56 Quite High
Pain 2 80.76 Quite High
Convulsion 1 80.40 Quite High
Bacterial Infection 2 76.24 Quite High
Urological Neuroanatomy 1 75.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Chronic antidepressant administration increases the expression of cAMP-specific phosphodiesterase 4A and 4B isoforms.
Positive_regulation (increases) of Gene_expression (expression) of cAMP associated with antidepressant
1) Confidence 0.49 Published 1999 Journal J. Neurosci. Section Title Doc Link 9880581 Disease Relevance 0.16 Pain Relevance 0.51
We found that PDE4 family is the major cAMP-PDE expressed in human fetal membranes and that PDE4 activity is increased by LPS treatment.
Positive_regulation (increased) of Gene_expression (expressed) of cAMP
2) Confidence 0.49 Published 2005 Journal J. Immunol. Section Abstract Doc Link 15944316 Disease Relevance 0.77 Pain Relevance 0.49
Although the sweat antimicrobial peptides, dermcidin and human cathelicidin antimicrobial peptide 18 (hCAP-18)/LL-37, were detected in the fluid of the vesicles/pustules, neither dermcidin nor hCAP-18/LL-37 were overexpressed by neighboring keratinocytes.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of LL-37 in sweat
3) Confidence 0.22 Published 2010 Journal J. Invest. Dermatol. Section Abstract Doc Link 20393482 Disease Relevance 0.68 Pain Relevance 0.08
Although the sweat antimicrobial peptides, dermcidin and human cathelicidin antimicrobial peptide 18 (hCAP-18)/LL-37, were detected in the fluid of the vesicles/pustules, neither dermcidin nor hCAP-18/LL-37 were overexpressed by neighboring keratinocytes.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of hCAP-18 in sweat
4) Confidence 0.16 Published 2010 Journal J. Invest. Dermatol. Section Abstract Doc Link 20393482 Disease Relevance 0.68 Pain Relevance 0.08
The overexpressed LL37 binds to extracellular self-DNA and forms aggregates that enter pDCs, activate TLR 9, and trigger type I IFN production.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of LL37
5) Confidence 0.12 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2933899 Disease Relevance 1.44 Pain Relevance 0.39

General Comments

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