INT79413

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Context Info
Confidence 0.75
First Reported 1999
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 13
Total Number 13
Disease Relevance 8.30
Pain Relevance 4.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (CAMP)
Anatomy Link Frequency
sweat 5
DRG 2
immune cells 1
CAMP (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 147 100.00 Very High Very High Very High
Root ganglion neuron 18 99.84 Very High Very High Very High
Calcitonin gene-related peptide 18 99.74 Very High Very High Very High
antidepressant 7 99.40 Very High Very High Very High
lidocaine 102 97.40 Very High Very High Very High
adenocard 3 91.24 High High
Inflammatory response 18 88.96 High High
Serotonin 1 86.08 High High
Pain 5 85.96 High High
psoriasis 19 85.08 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 166 100.00 Very High Very High Very High
Disorder Of Lipid Metabolism 12 100.00 Very High Very High Very High
Cramps 11 100.00 Very High Very High Very High
Injury 10 95.32 Very High Very High Very High
Ganglion Cysts 2 93.56 High High
Dermatitis 28 92.48 High High
Disease 51 91.20 High High
Psoriasis 72 90.24 High High
Asthma 5 88.20 High High
Pulmonary Disease 5 87.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Chronic antidepressant administration increases the expression of cAMP-specific phosphodiesterase 4A and 4B isoforms.
Gene_expression (expression) of cAMP associated with antidepressant
1) Confidence 0.75 Published 1999 Journal J. Neurosci. Section Title Doc Link 9880581 Disease Relevance 0.16 Pain Relevance 0.51
We found that PDE4 family is the major cAMP-PDE expressed in human fetal membranes and that PDE4 activity is increased by LPS treatment.
Gene_expression (expressed) of cAMP
2) Confidence 0.75 Published 2005 Journal J. Immunol. Section Abstract Doc Link 15944316 Disease Relevance 0.71 Pain Relevance 0.45
Cilomilast shows high selectivity for cAMP-specific PDE4, an isoenzyme that predominates in pro-inflammatory and immune cells and that is 10-fold more selective for PDE4D than for PDE4A, -B or -C.
Gene_expression (selective) of cAMP in immune cells associated with inflammation
3) Confidence 0.65 Published 2007 Journal Expert Opin Investig Drugs Section Abstract Doc Link 17155857 Disease Relevance 1.36 Pain Relevance 0.32
kDa high-density lipoprotein complex composed of apolipoprotein A-I (apoA-I), haptoglobin-related protein (Hpr), apoliprotein L-I (APOL1), human cathelicidin antimicrobial peptide (hCAP18), GPI-specific phospholipase D (GPI-PLD), apolipoprotein A-II, and paraoxanase [106, 110], and (ii) TLF2, a 1000?
Gene_expression (composed) of hCAP18 associated with disorder of lipid metabolism
4) Confidence 0.65 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2826769 Disease Relevance 0.46 Pain Relevance 0
Thus, exudate CRAMP/LL-37 may also contribute to increased PMN numbers obtained at 4 h in lidocaine-treated mice (Fig. 1A).
Gene_expression (exudate) of LL-37 associated with cramps and lidocaine
5) Confidence 0.65 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2268966 Disease Relevance 0.29 Pain Relevance 0.52
Thus, it is likely that decreases in CGRP release and cAMP levels in DRG isolated from SHRs are mainly caused by AT(1) receptor activation by Ang II through an autocrine mechanism.
Gene_expression (levels) of cAMP in DRG associated with root ganglion neuron and calcitonin gene-related peptide
6) Confidence 0.58 Published 2009 Journal Transl Res Section Abstract Doc Link 19665690 Disease Relevance 0.15 Pain Relevance 0.69
Although ARBs reversed decreases in CGRP release and cAMP levels in the presence of Ang II in DRG isolated from WKYs, they increased CGRP release and cAMP levels in the absence of Ang II in DRG isolated from SHRs.
Gene_expression (levels) of cAMP in DRG associated with root ganglion neuron and calcitonin gene-related peptide
7) Confidence 0.58 Published 2009 Journal Transl Res Section Abstract Doc Link 19665690 Disease Relevance 0.22 Pain Relevance 0.72
Although the sweat antimicrobial peptides, dermcidin and human cathelicidin antimicrobial peptide 18 (hCAP-18)/LL-37, were detected in the fluid of the vesicles/pustules, neither dermcidin nor hCAP-18/LL-37 were overexpressed by neighboring keratinocytes.
Gene_expression (overexpressed) of hCAP-18 in sweat
8) Confidence 0.25 Published 2010 Journal J. Invest. Dermatol. Section Abstract Doc Link 20393482 Disease Relevance 0.68 Pain Relevance 0.08
Although the sweat antimicrobial peptides, dermcidin and human cathelicidin antimicrobial peptide 18 (hCAP-18)/LL-37, were detected in the fluid of the vesicles/pustules, neither dermcidin nor hCAP-18/LL-37 were overexpressed by neighboring keratinocytes.
Gene_expression (overexpressed) of LL-37 in sweat
9) Confidence 0.25 Published 2010 Journal J. Invest. Dermatol. Section Abstract Doc Link 20393482 Disease Relevance 0.68 Pain Relevance 0.08
Although the sweat antimicrobial peptides, dermcidin and human cathelicidin antimicrobial peptide 18 (hCAP-18)/LL-37, were detected in the fluid of the vesicles/pustules, neither dermcidin nor hCAP-18/LL-37 were overexpressed by neighboring keratinocytes.
Gene_expression (detected) of hCAP-18 in sweat
10) Confidence 0.19 Published 2010 Journal J. Invest. Dermatol. Section Abstract Doc Link 20393482 Disease Relevance 0.72 Pain Relevance 0.08
Although the sweat antimicrobial peptides, dermcidin and human cathelicidin antimicrobial peptide 18 (hCAP-18)/LL-37, were detected in the fluid of the vesicles/pustules, neither dermcidin nor hCAP-18/LL-37 were overexpressed by neighboring keratinocytes.
Gene_expression (detected) of cathelicidin antimicrobial peptide 18 in sweat
11) Confidence 0.19 Published 2010 Journal J. Invest. Dermatol. Section Abstract Doc Link 20393482 Disease Relevance 0.73 Pain Relevance 0.09
Although the sweat antimicrobial peptides, dermcidin and human cathelicidin antimicrobial peptide 18 (hCAP-18)/LL-37, were detected in the fluid of the vesicles/pustules, neither dermcidin nor hCAP-18/LL-37 were overexpressed by neighboring keratinocytes.
Gene_expression (detected) of LL-37 in sweat
12) Confidence 0.17 Published 2010 Journal J. Invest. Dermatol. Section Abstract Doc Link 20393482 Disease Relevance 0.71 Pain Relevance 0.08
The overexpressed LL37 binds to extracellular self-DNA and forms aggregates that enter pDCs, activate TLR 9, and trigger type I IFN production.
Gene_expression (overexpressed) of LL37
13) Confidence 0.16 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2933899 Disease Relevance 1.44 Pain Relevance 0.39

General Comments

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