INT79425

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Context Info
Confidence 0.65
First Reported 1998
Last Reported 2010
Negated 4
Speculated 1
Reported most in Body
Documents 42
Total Number 43
Disease Relevance 36.37
Pain Relevance 6.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
smooth muscle 8
SMA 4
liver 2
PSC 2
SMN 2
SMN1 (Homo sapiens)
Pain Link Frequency Relevance Heat
imagery 35 100.00 Very High Very High Very High
cva 15 99.68 Very High Very High Very High
Chronic pancreatitis 26 98.40 Very High Very High Very High
Inflammation 47 97.92 Very High Very High Very High
fibrosis 32 97.44 Very High Very High Very High
ischemia 17 97.20 Very High Very High Very High
Visceral pain 2 93.60 High High
Lasting pain 1 91.52 High High
cytokine 1 89.36 High High
corticosteroid 10 88.40 High High
Disease Link Frequency Relevance Heat
Syndrome 78 100.00 Very High Very High Very High
Multiple System Atrophy 2 99.92 Very High Very High Very High
Autoimmune Hepatitis 1118 99.82 Very High Very High Very High
Spinal Muscular Atrophy 5 99.78 Very High Very High Very High
Cancer 191 99.76 Very High Very High Very High
Primary Sclerosing Cholangitis 91 99.70 Very High Very High Very High
Abdominal Aortic Aneurysm 2 99.68 Very High Very High Very High
Cv General 3 Under Development 10 99.66 Very High Very High Very High
Leiomyosarcoma 26 98.88 Very High Very High Very High
Fibroma 94 98.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Since the SMA was found in only 80% of the clinical study this suggests that this artery may not always be present or identifiable.
Gene_expression (found) of SMA in artery
1) Confidence 0.65 Published 2009 Journal World J Surg Oncol Section Body Doc Link PMC2760553 Disease Relevance 0.17 Pain Relevance 0
Immunohistochemically, the tumor cells were positive for vimentin, SMA, MSA, CD34, laminin and a scattered number for S-100.
Gene_expression (positive) of SMA associated with cancer and multiple system atrophy
2) Confidence 0.65 Published 1998 Journal Acta Ophthalmol Scand Section Abstract Doc Link 9881563 Disease Relevance 0.99 Pain Relevance 0.08
USod-R and DSod-F contain XhoI and SmaI restriction endonuclease sites to allow for the directional cloning of the kan-sacB fragment.
Gene_expression (contain) of SmaI
3) Confidence 0.65 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2671405 Disease Relevance 0.14 Pain Relevance 0
The provided tissue (0.5 cm3) was diagnostic for nasopharyngeal angiofibroma after routine hematoxylin and eosin (H&E) staining (Figure 1), the stromal cells were negative for both cluster of differentiation (CD) 34 antigen and smooth muscle actin (SMA) antibodies and C-kit antibody was rarely detected in single cells.
Gene_expression (antibodies) of SMA in stromal cells associated with nasal tumor
4) Confidence 0.65 Published 2008 Journal J Med Case Reports Section Body Doc Link PMC2535598 Disease Relevance 1.01 Pain Relevance 0
Smooth muscle actin (SMA) was positive in two of the four cases of CMF (50%; 2/4) [Figure 5C].
Gene_expression (positive) of SMA in Smooth muscle associated with fibroma
5) Confidence 0.58 Published 2007 Journal Diagn Pathol Section Body Doc Link PMC2203974 Disease Relevance 0.95 Pain Relevance 0
Superior mesenteric artery (SMA) syndrome is a rare acquired disorder in which acute angulation of SMA causes compression of the third part of the duodenum between the SMA and the aorta, leading to obstruction.
Gene_expression (compression) of SMA in SMA associated with syndrome
6) Confidence 0.48 Published 2008 Journal Nepal Med Coll J Section Abstract Doc Link 18828443 Disease Relevance 0.53 Pain Relevance 0.11
Superior mesenteric artery (SMA) syndrome is a rare acquired disorder in which acute angulation of SMA causes compression of the third part of the duodenum between the SMA and the aorta, leading to obstruction.
Gene_expression (compression) of SMA in SMA associated with syndrome
7) Confidence 0.48 Published 2008 Journal Nepal Med Coll J Section Abstract Doc Link 18828443 Disease Relevance 0.54 Pain Relevance 0.12
Genetic tests for spinocerebellar ataxia (SCA) mutations, SCA3 and SCA6, and the common spinal muscular atrophy mutation (SMN1) were negative.
Neg (negative) Gene_expression (negative) of SMN1 in spinal associated with machado-joseph disease, spinocerebellar ataxia type 2 and spinal muscular atrophy
8) Confidence 0.46 Published 2006 Journal BMC Neurol Section Body Doc Link PMC1351204 Disease Relevance 0.82 Pain Relevance 0
Selective angiography of the SMA was performed using a 5F transfemoral Cobra catheter (Cordis, Roden, The Netherlands) which confirmed the diagnosis of dissection with compression of the proximal SMA (Figure 2).
Gene_expression (compression) of SMA in proximal
9) Confidence 0.45 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2848679 Disease Relevance 0.60 Pain Relevance 0.07
On this basis they established a set of treatment modalities for isolated spontaneous SMA dissection.
Gene_expression (dissection) of SMA
10) Confidence 0.45 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2848679 Disease Relevance 0.31 Pain Relevance 0.15
A curved multi-planar reconstruction of the SMA showed a dissection of the proximal SMA with extension into the jejunal and ileal arteries (Figure 1).
Gene_expression (dissection) of SMA in proximal
11) Confidence 0.45 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2848679 Disease Relevance 0.75 Pain Relevance 0.08
In children with SMA, the second SMN gene does produce this protein, but not in amounts sufficient to keep the child's motor neurons from degenerating.
Neg (not) Gene_expression (produce) of SMN gene in SMN
12) Confidence 0.42 Published 2008 Journal Philos Ethics Humanit Med Section Body Doc Link PMC2569955 Disease Relevance 0.75 Pain Relevance 0.09
S-100 protein, SMA and GFAP were negative.
Neg (negative) Gene_expression (negative) of SMA
13) Confidence 0.41 Published 2003 Journal Pathol. Int. Section Abstract Doc Link 14516322 Disease Relevance 1.49 Pain Relevance 0.06
The notable finding of this study was the presence of a contractile actin isoform, alpha-smooth muscle actin (SMA), in nonvascular cells in all of the seven torn human rotator cuff specimens evaluated immunohistochemically.
Gene_expression (presence) of SMA in smooth muscle
14) Confidence 0.38 Published 2001 Journal J. Orthop. Res. Section Abstract Doc Link 11347694 Disease Relevance 0.28 Pain Relevance 0.09
SMA is caused by a defect in one of the two survival motor neuron (SMN) genes that people have, a set of genes responsible for producing a protein necessary for the proper development and functioning of motor neurons.
Gene_expression (producing) of neuron in motor neurons
15) Confidence 0.32 Published 2008 Journal Philos Ethics Humanit Med Section Body Doc Link PMC2569955 Disease Relevance 0.92 Pain Relevance 0.10
The histological diagnosis of a leiomyosarcoma is unequivocal on the basis of the immunohistochemical expression of SMA.
Gene_expression (expression) of SMA associated with leiomyosarcoma
16) Confidence 0.24 Published 2008 Journal World J Surg Oncol Section Body Doc Link PMC2615012 Disease Relevance 1.84 Pain Relevance 0
This is the smallest AAA associated with SMA syndrome in the literature.
Gene_expression (syndrome) of SMA in SMA associated with syndrome and cva
17) Confidence 0.24 Published 2009 Journal Ann R Coll Surg Engl Section Abstract Doc Link 19833010 Disease Relevance 1.06 Pain Relevance 0.27
We propose an anatomical mechanism for SMA syndrome in this case.
Gene_expression (syndrome) of SMA in SMA associated with syndrome
18) Confidence 0.24 Published 2009 Journal Ann R Coll Surg Engl Section Abstract Doc Link 19833010 Disease Relevance 1.04 Pain Relevance 0.26
Immunohistochemical analysis revealed expression of C-kit (strongly positive), moderately positive stain for SMA, while markers for focal S-100 and CD 34 were negative (Figure 5).
Gene_expression (expression) of SMA
19) Confidence 0.19 Published 2009 Journal World J Surg Oncol Section Body Doc Link PMC2664807 Disease Relevance 1.38 Pain Relevance 0
This likely explains our negative finding of absent sensation of movement after rTMS over SMA.
Neg (negative) Gene_expression (explains) of SMA
20) Confidence 0.18 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2952623 Disease Relevance 0 Pain Relevance 0

General Comments

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