INT7944

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.70
First Reported 1989
Last Reported 2011
Negated 11
Speculated 10
Reported most in Abstract
Documents 193
Total Number 204
Disease Relevance 60.69
Pain Relevance 98.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Fos) DNA binding (Fos) transcription factor binding (Fos)
Anatomy Link Frequency
neurons 17
striatum 12
brain 10
nucleus 7
spinal 5
Fos (Mus musculus)
Pain Link Frequency Relevance Heat
Spinal cord 295 100.00 Very High Very High Very High
Kinase C 89 100.00 Very High Very High Very High
Glutamate 77 100.00 Very High Very High Very High
qutenza 74 100.00 Very High Very High Very High
GABAergic 57 100.00 Very High Very High Very High
nMDA receptor 49 100.00 Very High Very High Very High
Lasting pain 18 100.00 Very High Very High Very High
Dynorphin 9 100.00 Very High Very High Very High
Morphine 198 99.98 Very High Very High Very High
agonist 156 99.98 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 221 100.00 Very High Very High Very High
Stress 350 99.98 Very High Very High Very High
Hyperglycemia 48 99.98 Very High Very High Very High
Aids-related Complex 235 99.92 Very High Very High Very High
Depression 66 99.92 Very High Very High Very High
Nociception 255 99.90 Very High Very High Very High
Food Hypersensitivity 10 99.88 Very High Very High Very High
Convulsion 69 99.84 Very High Very High Very High
Urological Neuroanatomy 16 99.84 Very High Very High Very High
Cv Unclassified Under Development 15 99.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, non-noxious stimulation induced an increase of Fos positive neurons in the spinal cord of animals with tying of sciatic nerve.
Positive_regulation (increase) of Fos in sciatic nerve associated with sciatic nerve and spinal cord
1) Confidence 0.70 Published 2008 Journal Brain Res. Section Abstract Doc Link 18302958 Disease Relevance 0.78 Pain Relevance 0.85
The induction of c-fos mRNA of CP-treated mice was significantly inhibited by capsaicin pretreatment to deplete C-fibers.
Positive_regulation (induction) of c-fos mRNA associated with c fibre and qutenza
2) Confidence 0.70 Published 2008 Journal Neurosci. Res. Section Abstract Doc Link 18093676 Disease Relevance 0.40 Pain Relevance 0.75
The induction of c-fos mRNA exhibited a dose-dependency.
Positive_regulation (induction) of c-fos mRNA
3) Confidence 0.70 Published 2008 Journal Neurosci. Res. Section Abstract Doc Link 18093676 Disease Relevance 0.40 Pain Relevance 0.73
Besides pain- and stress-related brain areas and the tuberomamillary neurons, strong Fos activation and c-fos mRNA expression were found in distinct brain regions and cell types, which have not been activated in wild type control mice.
Positive_regulation (activation) of Fos in brain associated with stress and pain
4) Confidence 0.69 Published 2007 Journal Neuropharmacology Section Abstract Doc Link 17544458 Disease Relevance 0.46 Pain Relevance 0.26
Pretreatment with MK-801 prevented the haloperidol-produced induction of the striatal c-fos mRNA.
Positive_regulation (induction) of c-fos mRNA
5) Confidence 0.69 Published 1995 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 8750842 Disease Relevance 0 Pain Relevance 0
The aim of the study was to determine whether the haloperidol-produced induction of the c-fos gene in the mouse striatum is the cause of the increased expression of the striatal proenkephalin (PENK) gene after repeated haloperidol administration.
Spec (whether) Positive_regulation (induction) of c-fos gene in striatum
6) Confidence 0.69 Published 1995 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 8750842 Disease Relevance 0 Pain Relevance 0
Baclofen inhibits opiate-induced conditioned place preference and associated induction of Fos in cortical and limbic regions.
Positive_regulation (induction) of Fos associated with opiate
7) Confidence 0.69 Published 2003 Journal Brain Res. Section Title Doc Link 14499954 Disease Relevance 0 Pain Relevance 0.66
Fos immunoreactivity, a neuronal activity marker, was induced in opiate conditioned mice in several forebrain regions including the nucleus accumbens core and shell, anterior cingulate cortex, and prelimbic cortex.
Positive_regulation (induced) of Fos in shell associated with nucleus accumbens, opiate and anterior cingulate cortex
8) Confidence 0.69 Published 2003 Journal Brain Res. Section Abstract Doc Link 14499954 Disease Relevance 0 Pain Relevance 0.66
Baclofen pretreatment blocked the induction of Fos in opiate conditioned subjects.
Positive_regulation (induction) of Fos associated with opiate
9) Confidence 0.69 Published 2003 Journal Brain Res. Section Abstract Doc Link 14499954 Disease Relevance 0 Pain Relevance 0.68
The activation of cFos in response to light onset, and its circadian regulation, have been described in many studies [44-47].
Positive_regulation (activation) of cFos
10) Confidence 0.68 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2774458 Disease Relevance 0.19 Pain Relevance 0.03
Our results show that haloperidol, a DA D2-class receptor antagonist, activates c-Fos predominantly in enkephalin-positive striatal neurons, which project to the globus pallidus and are thought to mediate motor inhibition.
Positive_regulation (activates) of c-Fos in globus pallidus associated with dopamine, antagonist and enkephalin
11) Confidence 0.67 Published 2002 Journal J. Chem. Neuroanat. Section Abstract Doc Link 12048106 Disease Relevance 0.15 Pain Relevance 0.53
The induction of the immediate early gene c-fos by the dopamine D2 receptor antagonist haloperidol was not altered, while the selective D1 receptor agonist SKF 38393 failed to induce c-fos in the striatum of MPTP-treated mice.
Positive_regulation (induction) of c-fos in striatum associated with parkinson's disease, dopamine, antagonist and agonist
12) Confidence 0.67 Published 1995 Journal J Neural Transm Park Dis Dement Sect Section Abstract Doc Link 8527000 Disease Relevance 0.58 Pain Relevance 0.38
Although morphine tolerance increased formalin-evoked persistent pain behavior and Fos-LI in wild-type mice, there was no difference between placebo- and morphine-treated mutant mice, suggesting that PKC gamma also contributes to chronic morphine-induced changes in nociceptive processing.
Positive_regulation (increased) of Fos associated with nociception, pain, kinase c, lasting pain, tolerance and morphine
13) Confidence 0.67 Published 2001 Journal Pain Section Abstract Doc Link 11731061 Disease Relevance 0.38 Pain Relevance 2.07
DEM, APAP, and CCl(4) increased c-jun and c-fos mRNA levels, together with an increase in AP-1 binding; BSO failed to induce AP-1 despite an increase in c-fos.
Positive_regulation (increase) of c-fos
14) Confidence 0.67 Published 2000 Journal Hepatology Section Abstract Doc Link 10915739 Disease Relevance 0.30 Pain Relevance 0.08
Enhanced c-Fos in periaqueductal grey GABAergic neurons during opioid withdrawal.
Positive_regulation (Enhanced) of c-Fos in GABAergic neurons associated with gabaergic, periaqueductal grey, withdrawal and opioid
15) Confidence 0.67 Published 2005 Journal Neuroreport Section Title Doc Link 16056125 Disease Relevance 0.92 Pain Relevance 1.15
Additionally, c-Fos and the orexin gene itself are induced in orexin cells in the LH during morphine withdrawal.
Positive_regulation (induced) of c-Fos associated with withdrawal and morphine
16) Confidence 0.67 Published 2003 Journal J. Neurosci. Section Abstract Doc Link 12716916 Disease Relevance 0.34 Pain Relevance 1.19
Moreover, parallel to the effect on PKC activity, procaine was more potent than tetracaine as a c-Fos inducer.
Positive_regulation (inducer) of c-Fos associated with kinase c
17) Confidence 0.67 Published 1996 Journal Anesth. Analg. Section Abstract Doc Link 8780278 Disease Relevance 0 Pain Relevance 1.29
Pre-treatment of mice with dexamethasone, in a schedule which suppressed acute-phase gene expression after brain irradiation, did not significantly change c-fos and junB induction.
Neg (not) Positive_regulation (induction) of c-fos in brain associated with dexamethasone
18) Confidence 0.67 Published 1997 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9332719 Disease Relevance 0.07 Pain Relevance 0.18
The response was dose-dependent with increases in c-fos and junB mRNA levels after dose of > or = 2 and 7 Gy, respectively.
Positive_regulation (increases) of c-fos
19) Confidence 0.67 Published 1997 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9332719 Disease Relevance 0.08 Pain Relevance 0.16
Induction of c-fos and junB mRNA following in vivo brain irradiation.
Positive_regulation (Induction) of c-fos in brain
20) Confidence 0.67 Published 1997 Journal Brain Res. Mol. Brain Res. Section Title Doc Link 9332719 Disease Relevance 0.10 Pain Relevance 0.14

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox