INT79441

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Context Info
Confidence 0.62
First Reported 1999
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 6
Disease Relevance 3.98
Pain Relevance 2.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (XCL1) extracellular space (XCL1) extracellular region (XCL1)
cell-cell signaling (XCL1)
Anatomy Link Frequency
monocytes 1
BEAS-2B 1
XCL1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 21 100.00 Very High Very High Very High
aspirin 8 99.56 Very High Very High Very High
chemokine 4 98.76 Very High Very High Very High
cINOD 2 95.04 Very High Very High Very High
Pain 4 88.64 High High
Inflammation 5 87.92 High High
qutenza 5 87.56 High High
antagonist 3 87.00 High High
substance P 3 79.44 Quite High
Neuropeptide 1 53.20 Quite High
Disease Link Frequency Relevance Heat
Neuroblastoma 14 99.52 Very High Very High Very High
Cancer 18 99.38 Very High Very High Very High
Targeted Disruption 10 99.20 Very High Very High Very High
Adverse Drug Reaction 2 94.56 High High
INFLAMMATION 9 93.44 High High
Panniculitis 2 90.96 High High
Pain 4 88.64 High High
Fever 2 86.72 High High
Toxicity 4 45.68 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
They received up to 8 subcutaneous injections of a vaccine combining lymphotactin (Lptn)- and interleukin-2 (IL-2)-secreting allogeneic neuroblastoma cells in a dose-escalating scheme.
Localization (secreting) of Lptn associated with neuroblastoma
1) Confidence 0.62 Published 2003 Journal Blood Section Abstract Doc Link 12406881 Disease Relevance 0.86 Pain Relevance 0.17
They received up to 8 subcutaneous injections of a vaccine combining lymphotactin (Lptn)- and interleukin-2 (IL-2)-secreting allogeneic neuroblastoma cells in a dose-escalating scheme.
Localization (secreting) of lymphotactin associated with neuroblastoma
2) Confidence 0.54 Published 2003 Journal Blood Section Abstract Doc Link 12406881 Disease Relevance 0.87 Pain Relevance 0.17
Phase I trial of vaccination with autologous neuroblastoma tumor cells genetically modified to secrete IL-2 and lymphotactin.
Localization (secrete) of lymphotactin associated with neuroblastoma and cancer
3) Confidence 0.50 Published 2007 Journal J. Immunother. Section Title Doc Link 17471169 Disease Relevance 0.86 Pain Relevance 0.17
They each received up to 8 subcutaneous injections of a vaccine combining lymphotactin--and interleukin-2 (IL-2)--secreting autologous neuroblastoma cells in a dose-escalating scheme.
Localization (secreting) of lymphotactin associated with neuroblastoma
4) Confidence 0.38 Published 2007 Journal J. Immunother. Section Abstract Doc Link 17471169 Disease Relevance 0.84 Pain Relevance 0.17
Here, we tested the hypothesis that NCX-4016, a NO-aspirin derivative, inhibits proinflammatory cytokine release from endotoxin (LPS)-challenged monocytes.
Localization (release) of proinflammatory cytokine in monocytes associated with aspirin and cytokine
5) Confidence 0.01 Published 2000 Journal J. Immunol. Section Abstract Doc Link 11046058 Disease Relevance 0.24 Pain Relevance 0.38
BEAS-2B cells exposed to ROFA in calcium-free media failed to demonstrate increases of [Ca2+]i and showed reduced levels of cytokine transcript (i.e., IL-6, IL-8, TNFalpha) and IL-6 release, suggesting that ROFA-stimulated cytokine formation was partially dependent on extracellular calcium sources.
Localization (release) of cytokine transcript in BEAS-2B associated with cytokine
6) Confidence 0.01 Published 1999 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 9882597 Disease Relevance 0.30 Pain Relevance 0.93

General Comments

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