INT79455

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Context Info
Confidence 0.67
First Reported 1999
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 2.07
Pain Relevance 1.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PDE4A) signal transduction (PDE4A) plasma membrane (PDE4A)
nucleus (PDE4A) cytoplasm (PDE4A)
PDE4A (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 46 99.20 Very High Very High Very High
Paracetamol 6 98.72 Very High Very High Very High
cytokine 409 92.88 High High
Inflammatory response 7 89.96 High High
metalloproteinase 2 85.80 High High
Dismenorea 1 84.56 Quite High
Inflammatory marker 2 25.36 Quite Low
COX2 1 25.00 Low Low
cINOD 1 25.00 Low Low
chemokine 14 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 58 99.20 Very High Very High Very High
Overdose 4 99.08 Very High Very High Very High
Vasculitis 4 98.68 Very High Very High Very High
Dysmenorrhea 1 84.56 Quite High
Bacterial Infection 1 77.24 Quite High
Increased Venous Pressure Under Development 16 76.08 Quite High
Premature Rupture Fetal Membranes 1 75.56 Quite High
Infection 5 72.88 Quite High
Rupture 2 67.84 Quite High
Toxicity 184 51.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
There are four different genes encoding the cAMP-specific phosphodiesterase (PDE4) isozymes (A, B, C, and D). cAMP has been the only agent known to induce PDE4 gene expression.
Positive_regulation (induce) of Gene_expression (expression) of PDE4
1) Confidence 0.67 Published 1999 Journal Mol. Pharmacol. Section Abstract Doc Link 9882697 Disease Relevance 0 Pain Relevance 0
We found that PDE4 family is the major cAMP-PDE expressed in human fetal membranes and that PDE4 activity is increased by LPS treatment.
Positive_regulation (increased) of Gene_expression (expressed) of PDE4
2) Confidence 0.50 Published 2005 Journal J. Immunol. Section Abstract Doc Link 15944316 Disease Relevance 0.78 Pain Relevance 0.49
Several phosphodiesterase IV (PDE4) inhibitors induce inflammatory vascular injury in preclinical species.
Positive_regulation (Several) of Gene_expression (Several) of phosphodiesterase IV associated with inflammation and vasculitis
3) Confidence 0.30 Published 2010 Journal Toxicological Sciences Section Body Doc Link PMC2923281 Disease Relevance 0.65 Pain Relevance 0.51
Several phosphodiesterase IV (PDE4) inhibitors induce inflammatory vascular injury in preclinical species.
Positive_regulation (Several) of Gene_expression (Several) of PDE4 associated with inflammation and vasculitis
4) Confidence 0.30 Published 2010 Journal Toxicological Sciences Section Body Doc Link PMC2923281 Disease Relevance 0.65 Pain Relevance 0.51

General Comments

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