INT79458

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Context Info
Confidence 0.81
First Reported 1998
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 30
Total Number 40
Disease Relevance 11.13
Pain Relevance 15.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Prkca) endoplasmic reticulum (Prkca) enzyme binding (Prkca)
protein complex (Prkca) cytoplasm (Prkca) cytosol (Prkca)
Anatomy Link Frequency
platelets 2
muscle 1
nucleus 1
ganglion cells 1
PGE2 1
Prkca (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 1153 100.00 Very High Very High Very High
agonist 173 99.86 Very High Very High Very High
fluoxetine 20 99.78 Very High Very High Very High
Morphine 233 99.72 Very High Very High Very High
opioid receptor 254 99.28 Very High Very High Very High
antagonist 128 98.66 Very High Very High Very High
Central nervous system 14 98.36 Very High Very High Very High
bradykinin 61 97.72 Very High Very High Very High
Inflammatory mediators 37 97.52 Very High Very High Very High
Glutamate 49 96.76 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 61 100.00 Very High Very High Very High
Cancer 168 99.42 Very High Very High Very High
Reperfusion Injury 150 98.80 Very High Very High Very High
Virus Diseases 94 98.76 Very High Very High Very High
Obesity 101 98.68 Very High Very High Very High
Infection 27 98.60 Very High Very High Very High
Targeted Disruption 316 98.50 Very High Very High Very High
Parkinson's Disease 580 98.32 Very High Very High Very High
Diabetes Mellitus 72 98.28 Very High Very High Very High
Death 44 97.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
According to our results, fluoxetine seemed to modulate calcium influx, which, in turn, would influence PKC translocation, modulating the immune response.
Localization (translocation) of PKC associated with fluoxetine
1) Confidence 0.81 Published 1998 Journal Cell. Signal. Section Abstract Doc Link 9884023 Disease Relevance 0.08 Pain Relevance 0.56
We observed that fluoxetine increased PKC translocation obtained with 1 microg/mL Con A concentration, whereas PKC was degraded when 2 microg/mL was used.
Localization (translocation) of PKC associated with fluoxetine
2) Confidence 0.81 Published 1998 Journal Cell. Signal. Section Abstract Doc Link 9884023 Disease Relevance 0.09 Pain Relevance 0.61
In contrast, we showed here that the activation and membrane translocation of PKC isoforms were not affected by BDV infection.
Localization (translocation) of PKC associated with virus diseases, kinase c and infection
3) Confidence 0.56 Published 2006 Journal PLoS Pathogens Section Body Doc Link PMC1401496 Disease Relevance 0.80 Pain Relevance 0.64
mediates granule secretion (19), that PKC?
Localization (secretion) of PKC associated with kinase c
4) Confidence 0.47 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2906332 Disease Relevance 0.13 Pain Relevance 0.65
Protein kinase C (PKC) activities were markedly reduced in diabetic transgenic mice, and the changes were associated with reduced expression of membrane PKC-alpha isoform that was translocated to cytosol.
Localization (translocated) of PKC-alpha associated with targeted disruption, kinase c and diabetes mellitus
5) Confidence 0.46 Published 2004 Journal Diabetes Section Abstract Doc Link 15561956 Disease Relevance 1.85 Pain Relevance 0.41
This may suggest that in human platelets, there is more redundancy of function between PKC?
Localization (redundancy) of PKC in platelets associated with kinase c
6) Confidence 0.44 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2906332 Disease Relevance 0.07 Pain Relevance 0.52
platelets for secretion and PKC??
Localization (secretion) of PKC in platelets associated with kinase c
7) Confidence 0.41 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2906332 Disease Relevance 0.14 Pain Relevance 1.03
We have previously reported that retinal CaMKII mRNA, protein and enzyme activity (localized in the somas of amacrine cells and ganglion cells and in the inner plexifom layer) but not PKC?
Neg (not) Localization (localized) of PKC in ganglion cells associated with ganglion cysts
8) Confidence 0.40 Published 2001 Journal BMC Neurosci Section Body Doc Link PMC32198 Disease Relevance 0.18 Pain Relevance 0.16
Another study suggests that activation of PKC (translocation of PKCdelta) by GGA plays a role in mediating HSF translocation [24].
Localization (translocation) of PKC in HSF
9) Confidence 0.32 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2670514 Disease Relevance 0.96 Pain Relevance 0.03
Afterwards, nitric oxide (NO)-released zinc ions recruited PKC?
Localization (recruited) of PKC
10) Confidence 0.28 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2890584 Disease Relevance 0.13 Pain Relevance 0.98
association involves the cysteine rich domains in the regulatory C1 region of PKC?
Localization (region) of PKC associated with kinase c
11) Confidence 0.28 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890584 Disease Relevance 0.18 Pain Relevance 1.11
In a previous study, we reported that morphine promotes the recruitment of PKC?
Localization (recruitment) of PKC associated with kinase c and morphine
12) Confidence 0.28 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890584 Disease Relevance 0.19 Pain Relevance 1.13
These, identified by microarray include, PI3-K, JAK2, JAK3, STAT3, Grb2, IRS, and PLCgamma1, Rho-GTPase activating protein (RAB35), kinases (MEK kinase 1 and 4, PKC, MLCK, cyclin G-associated kinase, EphA1, JNK kinase, MAP kinase 1), phosphatases (meprin, PTPK, protein phosphatase 2 subunit), and heat shock proteins (Hsp60 precursor), as well as SOCS (25).
Localization (cyclin) of PKC associated with shock
13) Confidence 0.26 Published 2005 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1297502 Disease Relevance 0.18 Pain Relevance 0.07
PGE2 or PGI2increased or sensitized TRPV1 responses through EP1 or IP receptors, respectively predominantly in a PKC-dependent manner in both HEK293 cells expressing TRPV1 and mouse DRG neurons.
Localization (manner) of PKC-dependent in PGE2
14) Confidence 0.22 Published 2005 Journal Mol Pain Section Abstract Doc Link PMC1074353 Disease Relevance 0.67 Pain Relevance 0.51
translocation inhibitor (PKC?
Localization (translocation inhibitor) of PKC
15) Confidence 0.22 Published 2005 Journal Mol Pain Section Body Doc Link PMC1074353 Disease Relevance 0 Pain Relevance 0.16
There are multiple regulators of G-protein signaling (RGS) (Chidiac and Roy 2003) that directly modulate G-protein function; multiple receptors for activated PKC (RACKs) that may be important for translocation of PKC to specific intracellular locations; and multiple anchoring proteins that can regulate the location, function, and interaction of various protein kinases (Scott 1997; Bayer and Schulman 2001).
Localization (translocation) of PKC associated with kinase c
16) Confidence 0.19 Published 2005 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2426818 Disease Relevance 0 Pain Relevance 0.27
There are multiple regulators of G-protein signaling (RGS) (Chidiac and Roy 2003) that directly modulate G-protein function; multiple receptors for activated PKC (RACKs) that may be important for translocation of PKC to specific intracellular locations; and multiple anchoring proteins that can regulate the location, function, and interaction of various protein kinases (Scott 1997; Bayer and Schulman 2001).
Localization (translocation) of PKC associated with kinase c
17) Confidence 0.18 Published 2005 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2426818 Disease Relevance 0 Pain Relevance 0.27
PAR2-AP was ineffective in causing translocation of PKC?
Localization (translocation) of PKC
18) Confidence 0.17 Published 2010 Journal Mol Pain Section Body Doc Link PMC2956715 Disease Relevance 0 Pain Relevance 0.11
Translocation of PKC?
Localization (Translocation) of PKC
19) Confidence 0.17 Published 2010 Journal Mol Pain Section Body Doc Link PMC2956715 Disease Relevance 0.08 Pain Relevance 0.29
We next examined the histological characteristics of thrombin-responsive neurons, using translocation of PKC?
Localization (translocation) of PKC in neurons
20) Confidence 0.17 Published 2010 Journal Mol Pain Section Body Doc Link PMC2956715 Disease Relevance 0.06 Pain Relevance 0.07

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